FGF1 antibody (C-Term)

Catalog No. ABIN966136

Product Details anti-FGF1 Antibody

Target: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Please inquire

Clonality: Polyclonal

Conjugate: This FGF1 antibody is un-conjugated

Application: Western Blotting (WB)

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human FGF1, identical to the related rat and mouse sequence.

Application Details

Restrictions: For Research Use only

Handling

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: Thimerosal (Merthiolate), Sodium azide

Storage: -20 °C

References for anti-FGF1 antibody (ABIN966136)

Le Beau, Espinosa, Neuman, Stock, Roulston, Larson, Keinanen, Westbrook: "Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 12, pp. 5484-8, (1993) (PubMed).

Mergia, Eddy, Abraham, Fiddes, Shows: "The genes for basic and acidic fibroblast growth factors are on different human chromosomes." in: Biochemical and biophysical research communications, Vol. 138, Issue 2, pp. 644-51, (1986) (PubMed).

Burgess, Mehlman, Marshak, Fraser, Maciag: "Structural evidence that endothelial cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 19, pp. 7216-20, (1986) (PubMed).

Target Details for FGF1

Target: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Alternative Name: FGF1 (FGF1 Products)

Synonyms: AFGF antibody, ECGF antibody, ECGF-beta antibody, ECGFA antibody, ECGFB antibody, FGF-1 antibody, FGF-alpha antibody, FGFA antibody, GLIO703 antibody, HBGF-1 antibody, HBGF1 antibody, Fgf1 antibody, FGF1 antibody, aFGF antibody, ecgf antibody, fgfa antibody, ecgfa antibody, ecgfb antibody, fgf-1 antibody, hbgf1 antibody, glio703 antibody, ecgf-beta antibody, fgf-alpha antibody, Dffrx antibody, Fam antibody, Fgf-1 antibody, Fgfa antibody, zgc:136885 antibody, LOC100221393 antibody, fgf1 antibody, zgc:73249 antibody, fibroblast growth factor 1 antibody, fibroblast growth factor 1 L homeolog antibody, fibroblast growth factor 1b antibody, fibroblast growth factor 1a antibody, FGF1 antibody, fgf1.L antibody, fgf1 antibody, Fgf1 antibody, fgf1b antibody, LOC100221393 antibody, fgf1a antibody

Background: Fibroblast growth factor 1 (acidic), also known as FGF1/ECGF/HBGF1, is a human gene which is mapped to 5q311. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Additionally, Acidic fibroblast growth factor is derived from beta-endothelial cell growth factor (ECGFB) by posttranslational processing. Alpha-ECGF is also derived from ECGFB in the same manner.2, 3

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway