FGFR4 antibody (Extracellular)

Catalog No. ABIN966141

Product Details anti-FGFR4 Antibody

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Binding Specificity: Extracellular

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FGFR4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: Ascitic fluid

Immunogen: Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.

Clone: 7H1

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-FGFR4 antibody (ABIN966141)

Streit, Mestel, Schmidt, Ullrich, Berking: "FGFR4 Arg388 allele correlates with tumour thickness and FGFR4 protein expression with survival of melanoma patients." in: British journal of cancer, Vol. 94, Issue 12, pp. 1879-86, (2006) (PubMed).

Target Details for FGFR4

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Alternative Name: FGFR4 (FGFR4 Products)

Synonyms: FGFR4 antibody, XFGFR-4 antibody, XFGFR-4a antibody, cd334 antibody, fgfr-4 antibody, jtk2 antibody, tkf antibody, xfgfr4 antibody, CD334 antibody, JTK2 antibody, TKF antibody, Fgfr-4 antibody, etID309818.21 antibody, wu:fc13h10 antibody, zgc:111935 antibody, fgfr-4c antibody, fgfr4 antibody, fibroblast growth factor receptor 4 antibody, fibroblast growth factor receptor 4 S homeolog antibody, FGFR4 antibody, fgfr4 antibody, Fgfr4 antibody, fgfr4.S antibody

Background: FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Synonyms: TKF, JTK2, CD334

Molecular Weight: 87.9kDa

Gene ID: 811

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding