FOXD3 antibody

Catalog No. ABIN966161

Product Details anti-FOXD3 Antibody

Target: FOXD3 (Forkhead Box D3 (FOXD3))

Reactivity: Human, Mouse, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This FOXD3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human FOXD3 expressed in E. Coli.

Clone: 5G9

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-FOXD3 antibody (ABIN966161)

Saleem, Banerjee-Basu, Berry, Baxevanis, Walter: "Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1." in: American journal of human genetics, Vol. 68, Issue 3, pp. 627-41, (2001) (PubMed).

Hromas, Moore, Johnston, Socha, Klemsz: "Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells." in: Blood, Vol. 81, Issue 11, pp. 2854-9, (1993) (PubMed).

Target Details for FOXD3

Target: FOXD3 (Forkhead Box D3 (FOXD3))

Alternative Name: FOXD3 (FOXD3 Products)

Synonyms: AIS1 antibody, Genesis antibody, HFH2 antibody, VAMAS2 antibody, CWH3 antibody, Hfh2 antibody, fkd6 antibody, fkh6 antibody, forkhead-6 antibody, zgc:111934 antibody, XFD-6 antibody, xfoxd3 antibody, FOXD3 antibody, genesis antibody, hfh2 antibody, foxd3b antibody, foxd3b-A antibody, forkhead box D3 antibody, forkhead box D3 L homeolog antibody, forkhead box D3 S homeolog antibody, FOXD3 antibody, Foxd3 antibody, foxd3 antibody, foxd3.L antibody, foxd3.S antibody

Background: FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation . FoxD3 is required for the maintenance of the mammalian neural crest, FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures . FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .
Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined .
Synonyms: AIS1, HFH2, Genesis, FOXD3

Molecular Weight: 48kDa

Gene ID: 27022