Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) (N-Term), (pSer516) antibody

Details for Product No. ABIN966302
Antigen
Epitope
N-Term, pSer516
10
9
7
7
3
2
2
2
1
1
1
1
1
Reactivity
Human
57
17
11
Host
Rabbit
44
13
Clonality
Polyclonal
Conjugate
Un-conjugated
3
2
2
2
2
2
1
1
1
1
1
1
Application
34
31
28
11
5
3
3
3
2
2
1
Options
Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near N-terminal residues of human HRX (Histone-lysine N-methyltransferase HRX)
Antigen
Alternative Name HRX (MLL Antibody Abstract)
Background HRX (Histone-lysine N-methyltransferase HRX) functions as histone methyltransferase. HRX methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. HRX promotes PPP1R15A-induced apoptosis. HRX interacts with SBF1 and PPP1R15A. HRX is a component of the MLL complex, at least composed of MLL, ASH2L, RBBP5, DPY30, WDR5, MEN1,HCFC1 and HCFC2. Chromosomal aberrations involving MLL are a cause of acute leukemias. A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. HRX belongs to the histone-lysine methyltransferase family and TRX/MLL subfamily.
Synonyms: ALL1, CXXC7(CXXC-type zinc finger protein 7), HTRX, KMT2A, TRX1, MLL, Zinc finger protein HRX, Trithorax-like protein, Lysine N-methyltransferase 2A
Restrictions For Research Use only
Product cited in: Nilson, Löchner, Siegler, Greil, Beck, Fey, Marschalek: "Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias." in: British journal of haematology, Vol. 93, Issue 4, pp. 966-72, 1996 (PubMed).

Mbangkollo, Burnett, McCabe, Thirman, Gill, Yu, Rowley, Diaz: "The human MLL gene: nucleotide sequence, homology to the Drosophila trx zinc-finger domain, and alternative splicing." in: DNA and cell biology, Vol. 14, Issue 6, pp. 475-83, 1995 (PubMed).

Gu, Alder, Nakamura, Schichman, Prasad, Canaani, Saito, Croce, Canaani: "Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia." in: Cancer research, Vol. 54, Issue 9, pp. 2327-30, 1994 (PubMed).

Gu, Nakamura, Alder, Prasad, Canaani, Cimino, Croce, Canaani: "The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene." in: Cell, Vol. 71, Issue 4, pp. 701-8, 1992 (PubMed).