KCNH1 antibody (C-Term)

Catalog No. ABIN966446

Product Details anti-KCNH1 Antibody

Target: KCNH1 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNH1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human KCNH1(Potassium voltage-gated channel subfamily H member 1)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-KCNH1 antibody (ABIN966446)

Schönherr, Gessner, Löber, Heinemann: "Functional distinction of human EAG1 and EAG2 potassium channels." in: FEBS letters, Vol. 514, Issue 2-3, pp. 204-8, (2002) (PubMed).

Schönherr, Löber, Heinemann: "Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin." in: The EMBO journal, Vol. 19, Issue 13, pp. 3263-71, (2000) (PubMed).

Pardo, del Camino, Sánchez, Alves, Brüggemann, Beckh, Stühmer: "Oncogenic potential of EAG K(+) channels." in: The EMBO journal, Vol. 18, Issue 20, pp. 5540-7, (1999) (PubMed).

Occhiodoro, Bernheim, Liu, Bijlenga, Sinnreich, Bader, Fischer-Lougheed: "Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion." in: FEBS letters, Vol. 434, Issue 1-2, pp. 177-82, (1998) (PubMed).

Target Details for KCNH1

Target: KCNH1 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1))

Alternative Name: KCNH1 (KCNH1 Products)

Synonyms: EAG antibody, bEAG antibody, EAG1 antibody, Kv10.1 antibody, h-eag antibody, M-eag antibody, Eag1 antibody, kcnh1 antibody, potassium voltage-gated channel subfamily H member 1 antibody, potassium channel, voltage gated eag related subfamily H, member 1 antibody, potassium voltage-gated channel, subfamily H (eag-related), member 1 antibody, potassium voltage-gated channel, subfamily H (eag-related), member 1a antibody, KCNH1 antibody, LOC490277 antibody, Kcnh1 antibody, kcnh1a antibody

Background: KCNH1 (Potassium voltage-gated channel subfamily H member 1) Is a pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. KCNH1 mediates IK(NI) current in myoblasts. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. KCNH1 interacts with ALG10B. KCNH1 is highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells. Overexpression of EAG may confer a growth advantage to cancer cells and favor tumor cell proliferation.
Synonyms: EAG (Voltage-gated potassium channel subunit Kv10.1), EAG1 (Ether-a-go-go potassium channel 1)