MAP2K1 antibody (Mitogen-Activated Protein Kinase Kinase 1) (pSer221)

Details for Product anti-MAP2K1 Antibody No. ABIN966560, Supplier: Log in to see
Antigen
  • Mek1
  • CFC3
  • MAPKK1
  • MEK1
  • MKK1
  • PRKMK1
  • MEKK1
  • Prkmk1
  • mek-2
  • si:ch211-242m18.2
  • wu:fj56a12
  • wu:fj61b01
  • zgc:56557
  • ATMEK1
  • F20B18.180
  • F20B18_180
  • MAP kinase/ ERK kinase 1
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE 1
  • NMAPKK
  • MEK
  • mitogen activated protein kinase kinase 1
  • mitogen-activated protein kinase kinase 1
  • mitogen-activated protein kinase kinase 1 L homeolog
  • MAP kinase/ ERK kinase 1
  • Map2k1
  • MAP2K1
  • map2k1.L
  • map2k1
  • MEK1
Alternatives
anti-Human MAP2K1 antibody for Western Blotting
Epitope
pSer221
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Conjugate
This MAP2K1 antibody is un-conjugated
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Application
Immunohistochemistry (IHC)
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Options
Supplier
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Supplier Product No.
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human MEK1 around the phosphorylation site of serine 221 (A-N-SP-F-V).
Specificity MEK1 (phospho-Ser221) antibody detects endogenous levels of MEK1 only when phosphorylated at serine 221.
Plasmids, Primers & others Plasmids, Primers & others MAP2K1 products on genomics-online (e.g. as negative or positive controls)
Alternative Name MEK1 (MAP2K1 Antibody Abstract)
Pathways MAPK Signaling, RTK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Zebisch, Staber, Delavar, Bodner, Hiden, Fischereder, Janakiraman, Linkesch, Auner, Emberger, Windpassinger, Schimek, Hoefler, Troppmair, Sill: "Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia." in: Cancer research, Vol. 66, Issue 7, pp. 3401-8, 2006 (PubMed).

Luciano, Hsu, Channavajhala, Lin, Cuozzo: "Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52117-23, 2004 (PubMed).

Product cited in: Gopalbhai, Jansen, Beauregard, Whiteway, Dumas, Wu, Meloche: "Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8118-25, 2003 (PubMed).

Wang, Jin, Wong, Feng, Wong, Tsao: "MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells." in: Oncogene, Vol. 22, Issue 1, pp. 109-16, 2003 (PubMed).

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