MMP1
Reactivity: Human
WB, ELISA, IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Western Bloting: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Format
Liquid
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Genevay, Finckh, Mezin, Tessitore, Guerne: "Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation." in: Arthritis research & therapy, Vol. 11, Issue 6, pp. R169, (2010) (PubMed).
Guan, Shu, Fu, Liu, Xu, Wu: "Prevotella intermedia upregulates MMP-1 and MMP-8 expression in human periodontal ligament cells." in: FEMS microbiology letters, Vol. 299, Issue 2, pp. 214-22, (2009) (PubMed).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. Synonyms: CLG, CLGN