Paxillin antibody (PXN) (pTyr31)

Details for Product anti-PXN Antibody No. ABIN966808
Target
Binding Specificity
pTyr31
27
27
18
15
12
11
8
8
7
6
6
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
221
133
133
19
11
9
6
5
5
4
4
3
1
1
1
1
Host
Rabbit
201
27
1
Conjugate
This Paxillin antibody is un-conjugated
12
11
7
7
7
7
7
6
5
4
4
4
4
4
2
2
1
1
1
1
Application
Immunohistochemistry (IHC)
159
66
58
53
32
25
21
16
7
7
4
2
2
1
1
Options
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Paxillin around the phosphorylation site of tyrosine 31 (T-P-YP-S-Y).
Specificity Paxillin (phospho-Tyr31) antibody detects endogenous levels of Paxillin only when phosphorylated at tyrosine 31.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Target
Alternative Name Paxillin (PXN Antibody Abstract)
Pathways MAPK Signaling, EGFR Signaling Pathway, Response to Growth Hormone Stimulus, Cell-Cell Junction Organization, Maintenance of Protein Location, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Davidson, Veillette: "PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates." in: The EMBO journal, Vol. 20, Issue 13, pp. 3414-26, 2001 (PubMed).

Fleming, Bauersachs, Schäfer, Scholz, Aldershvile, Busse: "Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 3, pp. 1123-8, 1999 (PubMed).