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PLAUR antibody (C-Term)

PLAUR Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN966859
  • Target See all PLAUR Antibodies
    PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))
    Binding Specificity
    • 16
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 64
    • 28
    • 27
    Human
    Host
    • 58
    • 15
    • 4
    • 3
    Rabbit
    Clonality
    • 65
    • 15
    Polyclonal
    Conjugate
    • 41
    • 8
    • 8
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PLAUR antibody is un-conjugated
    Application
    • 63
    • 31
    • 27
    • 20
    • 13
    • 12
    • 12
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Urokinase plasminogen activator surface receptor (PLAUR) detection. Tested with WB, IHC-P in Human.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminal of human PLAUR.< br/>Immunogen was affinity purified.
    Isotype
    IgG
    Top Product
    Discover our top product PLAUR Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Sodium azide, Thimerosal (Merthiolate)
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
  • Wang, Yang, Jamaluddin, Boyd: "The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells." in: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22674-83, (2004) (PubMed).

    Vagnarelli, Raimondi, Mazzieri, De Carli, Mignatti: "Assignment of the human urokinase receptor gene (PLAUR) to 19q13." in: Cytogenetics and cell genetics, Vol. 60, Issue 3-4, pp. 197-9, (1992) (PubMed).

  • Target
    PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))
    Alternative Name
    Urokinase plasminogen activator surface receptor(U-PAR/uPAR) (PLAUR Products)
    Synonyms
    Cd87 antibody, u-PAR antibody, uPAR antibody, CD87 antibody, U-PAR antibody, UPAR antibody, URKR antibody, Par antibody, Plaur3 antibody, uPAR-2 antibody, uPAR-3 antibody, PLAUR antibody, plasminogen activator, urokinase receptor antibody, Plaur antibody, PLAUR antibody
    Background
    PLAUR (PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13. 31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.
    Pathways
    Inositol Metabolic Process
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