RAB27A antibody

Catalog No. ABIN967619

Product Details anti-RAB27A Antibody

Target: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RAB27A antibody is un-conjugated

Application: Western Blotting (WB)

Brand: BD Pharmingen™

Characteristics: 1. Please refer to us for technical protocols.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Rab27A

Clone: 20-RAB27

Isotype: IgG1 kappa

Application Details

Comment:

Related Products: ABIN967389, ABIN968587

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-RAB27A antibody (ABIN967619)

Yoon, Kovalenko, Bogdanov, Wallach: "MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation." in: Immunity, Vol. 47, Issue 1, pp. 51-65.e7, (2017) (PubMed).

Hong: "Cytotoxic T lymphocyte exocytosis: bring on the SNAREs!" in: Trends in cell biology, Vol. 15, Issue 12, pp. 644-50, (2005) (PubMed).

Fukuda: "Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families." in: Journal of biochemistry, Vol. 137, Issue 1, pp. 9-16, (2005) (PubMed).

Izumi, Gomi, Kasai, Mizutani, Torii: "The roles of Rab27 and its effectors in the regulated secretory pathways." in: Cell structure and function, Vol. 28, Issue 5, pp. 465-74, (2004) (PubMed).

Target Details for RAB27A

Target: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Alternative Name: RAB27 (RAB27A Products)

Synonyms: MGC80943 antibody, RAB27A antibody, gs2 antibody, ram antibody, rab27 antibody, MGC89827 antibody, hst18676 antibody, zgc:114135 antibody, GS2 antibody, HsT18676 antibody, RAB27 antibody, RAM antibody, 2210402C08Rik antibody, 2410003M20Rik antibody, 4933437C11Rik antibody, ash antibody, RAB27A, member RAS oncogene family L homeolog antibody, RAB27A, member RAS oncogene family antibody, RAB27A, member RAS oncogene family S homeolog antibody, rab27a.L antibody, RAB27A antibody, rab27a antibody, rab27a.S antibody, Rab27a antibody

Background: Members of the Rab family of GTPases are non-transforming, membrane-bound, geranylgeranylated members of the Ras superfamily that are involved in the fusion and trafficking of cellular vesicles. Rab27A is expressed in many human tissues and it regulates the secreation of several types of cellular vesicles, such as melanosomes, insulin granules of pancreatic beta cells, and lytic granules of cytotoxic T lymphocytes. Rab27A is able to regulate such diverse processes by interacting with organelle-specific effector proteins, including melanophilin, granuphilin, and Munc13-4, respectively. Defects in Rab27A function are associated with the human diseases choroideremia and Griscelli syndrome 2 and the ashen mutant mouse. Rab27B is not so widely expressed, yet it is reported to have similar functional capacities as Rab27A.

Molecular Weight: 25 kDa

Pathways: Peptide Hormone Metabolism