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gamma 1 Adaptin antibody (AA 642-821)

AP1G1 Reactivity: Human, Mouse, Rat, Dog WB, IHC, IP, IF Host: Mouse Monoclonal 88-Adaptin gamma unconjugated
Catalog No. ABIN967934
  • Target See all gamma 1 Adaptin (AP1G1) Antibodies
    gamma 1 Adaptin (AP1G1) (Adaptor-Related Protein Complex 1, gamma 1 Subunit (AP1G1))
    Binding Specificity
    • 15
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 642-821
    Reactivity
    • 40
    • 26
    • 21
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog
    Host
    • 30
    • 7
    • 3
    Mouse
    Clonality
    • 32
    • 8
    Monoclonal
    Conjugate
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This gamma 1 Adaptin antibody is un-conjugated
    Application
    • 32
    • 13
    • 13
    • 12
    • 7
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Cross-Reactivity
    Rat (Rattus), Human, Dog (Canine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse Adaptin gamma aa. 642-821
    Clone
    88-Adaptin gamma
    Isotype
    IgG1
    Top Product
    Discover our top product AP1G1 Primary Antibody
  • Comment

    Related Products: ABIN968539, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Nagahama, Suzuki, Hamada, Hatsuzawa, Tani, Yamamoto, Tagaya: "SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 262-73, (2003) (PubMed).

    Eskelinen, Illert, Tanaka, Schwarzmann, Blanz, Von Figura, Saftig: "Role of LAMP-2 in lysosome biogenesis and autophagy." in: Molecular biology of the cell, Vol. 13, Issue 9, pp. 3355-68, (2002) (PubMed).

    Kalthoff, Groos, Kohl, Mahrhold, Ungewickell: "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi." in: Molecular biology of the cell, Vol. 13, Issue 11, pp. 4060-73, (2002) (PubMed).

    Wasiak, Legendre-Guillemin, Puertollano, Blondeau, Girard, de Heuvel, Boismenu, Bell, Bonifacino, McPherson: "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics." in: The Journal of cell biology, Vol. 158, Issue 5, pp. 855-62, (2002) (PubMed).

    Robinson: "Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus." in: The Journal of cell biology, Vol. 111, Issue 6 Pt 1, pp. 2319-26, (1991) (PubMed).

  • Target
    gamma 1 Adaptin (AP1G1) (Adaptor-Related Protein Complex 1, gamma 1 Subunit (AP1G1))
    Alternative Name
    Adaptin gamma (AP1G1 Products)
    Synonyms
    ADTG antibody, CLAPG1 antibody, AA409002 antibody, AU041323 antibody, AW551707 antibody, Adtg antibody, D8Ertd374e antibody, adtg antibody, wu:fc30a11 antibody, zgc:56079 antibody, AP1G1 antibody, adaptor related protein complex 1 gamma 1 subunit antibody, AP-1 complex subunit gamma-1 antibody, AP-1 adaptor complex gamma subunit Apl4 antibody, hypothetical protein antibody, adaptor protein complex AP-1, gamma 1 subunit antibody, adaptor-related protein complex 1, gamma 1 subunit antibody, adaptor related protein complex 1 gamma 1 subunit L homeolog antibody, gamma-adaptin antibody, AP1G1 antibody, NCU04121 antibody, PTRG_00081 antibody, SJAG_01809 antibody, UREG_02085 antibody, BDBG_07402 antibody, PAAG_11376 antibody, MCYG_00840 antibody, PITG_11143 antibody, VDBG_09354 antibody, Ap1g1 antibody, ap1g1 antibody, ap1g1.L antibody, ANI_1_330014 antibody, AOR_1_802184 antibody, MGYG_01130 antibody, EDI_324200 antibody, TERG_00390 antibody, Tsp_09544 antibody
    Background
    Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large Adaptin proteins (gamma, alpha, delta, or epsilon and beta1, beta2, beta3, or beta4, respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, or µ4) and one small chain ( sigma1, sigma2, sigma3, or sigma4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. Adaptin gamma shows more homology with Adaptin alpha than with Adaptin beta. The conserved regions between Adaptins gamma and alpha could be important for binding to other components of the AP-1 and AP-2 complexes, respectively.
    Molecular Weight
    104 kDa
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