XIAP antibody (AA 268-426)

Catalog No. ABIN968164

Product Details anti-XIAP Antibody

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Binding Specificity: AA 268-426

Reactivity: Human, Mouse, Rat, Frog

Host: Mouse

Clonality: Monoclonal

Conjugate: This XIAP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Cross-Reactivity: Rat (Rattus), Mouse (Murine), Frog

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human hILP aa. 268-426

Clone: 48-hILP-XIAP

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968537, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-XIAP antibody (ABIN968164)

Deng, Lin, Wu: "TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO." in: Genes & development, Vol. 16, Issue 1, pp. 33-45, (2002) (PubMed).

Martins, Iaccarino, Tenev, Gschmeissner, Totty, Lemoine, Savopoulos, Gray, Creasy, Dingwall, Downward: "The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 439-44, (2002) (PubMed).

Fulda, Meyer, Debatin: "Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression." in: Cancer research, Vol. 60, Issue 14, pp. 3947-56, (2000) (PubMed).

Tamm, Kornblau, Segall, Krajewski, Welsh, Kitada, Scudiero, Tudor, Qui, Monks, Andreeff, Reed: "Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 5, pp. 1796-803, (2000) (PubMed).

Duckett, Nava, Gedrich, Clem, Van Dongen, Gilfillan, Shiels, Hardwick, Thompson: "A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2685-94, (1996) (PubMed).

Target Details for XIAP

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Alternative Name: hILP (XIAP Products)

Synonyms: API3 antibody, BIRC4 antibody, IAP-3 antibody, ILP1 antibody, MIHA antibody, XLP2 antibody, hIAP-3 antibody, hIAP3 antibody, api3 antibody, birc4 antibody, ilp1 antibody, miha antibody, xlp2 antibody, xxiap antibody, 1110015C02Rik antibody, Aipa antibody, Api3 antibody, Birc4 antibody, IAP3 antibody, ILP-1 antibody, mXIAP antibody, riap3 antibody, fb73d01 antibody, wu:fb73d01 antibody, zgc:91873 antibody, BIRC8 antibody, X-linked inhibitor of apoptosis antibody, X-linked inhibitor of apoptosis L homeolog antibody, XIAP antibody, xiap antibody, xiap.L antibody, Xiap antibody

Background: Apoptosis is a genetically programmed, selective process of cell death that occurs during normal cell differentiation and development of multicellular organisms. Viruses depend on the biosynthetic machinery of their host cell for the production of progeny and survival. Therefore, many viruses encode proteins that protect the cell from apoptosis. hILP (human IAP-like protein) is a human homologue of the viral IAP (Inhibitor of Apoptosis Protein). hILP is a widely expressed cytoplasmic protein of 497 amino acids with three BIR (Baculovirus IAP repeats) domains and a C-terminal RING finger domain. hILP-transfected cells are protected against the apoptotic effects of Sindbis virus infection and ICE (interleukin-1beta converting enzyme) expression. This product is sold under license from Aegera Therapeutics, Inc. This antibody is routinely tested by western blot analysis.
Synonyms: hILP

Molecular Weight: 57 kDa

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis