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APBA3 antibody (AA 63-185)

APBA3 Reactivity: Human, Mouse WB, IF, BI Host: Mouse Monoclonal 32-Mint3 unconjugated
Catalog No. ABIN968505
  • Target See all APBA3 Antibodies
    APBA3 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3))
    Binding Specificity
    • 15
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 63-185
    Reactivity
    • 19
    • 17
    • 2
    • 1
    Human, Mouse
    Host
    • 34
    • 1
    Mouse
    Clonality
    • 35
    Monoclonal
    Conjugate
    • 16
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APBA3 antibody is un-conjugated
    Application
    • 33
    • 16
    • 13
    • 13
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI)
    Cross-Reactivity
    Human
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse Mint3 aa. 63-185
    Clone
    32-Mint3
    Isotype
    IgG1
    Top Product
    Discover our top product APBA3 Primary Antibody
  • Comment

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • McLoughlin, Irving, Brownlees, Brion, Leroy, Miller: "Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease." in: The European journal of neuroscience, Vol. 11, Issue 6, pp. 1988-94, (1999) (PubMed).

    Borg, Straight, Kaech, de Taddéo-Borg, Kroon, Karnak, Turner, Kim, Margolis: "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting." in: The Journal of biological chemistry, Vol. 273, Issue 48, pp. 31633-6, (1998) (PubMed).

    Borg, Yang, De Taddéo-Borg, Margolis, Turner: "The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion." in: The Journal of biological chemistry, Vol. 273, Issue 24, pp. 14761-6, (1998) (PubMed).

  • Target
    APBA3 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3))
    Alternative Name
    Mint3 (APBA3 Products)
    Synonyms
    AW208791 antibody, Mint-3 antibody, X11gamma antibody, lin-10 antibody, mint3 antibody, MGC:15815 antibody, X11L2 antibody, Mint3 antibody, amyloid beta precursor protein binding family A member 3 antibody, amyloid beta (A4) precursor protein-binding, family A, member 3 antibody, APBA3 antibody, Apba3 antibody
    Background
    Munc18-1-interacting proteins, Mint1, Mint2, and Mint3, are members of the X11 family of proteins, which contain a phosphotyrosine-binding (PTB) domain and two PSD-95-DLG-ZO-1 (PDZ) domains. The PTB domain binds Asn-Pro-X-pTyr, a beta-turn motif found on activated growth factor receptors and other signaling molecules. PDZ domains bind the C-terminus of proteins involved in receptor and channel clustering and protein localization in polarized cells. Both Mint1 and Mint2 are expressed primarily in the nervous system and may interact with Munc18-1 and syntaxin to form a multimeric complex that mediates appropriate docking/fusion of synaptic vesicles. In addition, both Mint1 and Mint2 may be involved in Alzheimer's disease, since Mint2 colocalizes with amyloid precursor protein (APP) and is found in neuritic plaques, while Mint1 can bind APP, and inhibits the processing of APP to the amyloid beta peptide. Mint3 can also bind APP, but differs from Mint1 and Mint2 in its N-terminal region. It is also more widely expressed. Thus, Mint3 may function in signaling pathways, vesicle exocytosis, and/or protein targeting in a wide range of tissues. Mint3 has a calculated molecular weight of 61 kD, but reportedly is observed migrating at 86-89 kD. This antibody is routinely tested by western blot analysis.
    Synonyms: X11gamma
    Molecular Weight
    86-89 kDa
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