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VTI1B antibody (AA 9-121)

VTI1B Reactivity: Human, Mouse, Rat WB, IF Host: Mouse Monoclonal 7-Vti1b unconjugated
Catalog No. ABIN968520
  • Target See all VTI1B Antibodies
    VTI1B (Vesicle Transport through Interaction with T-SNAREs Homolog 1B (VTI1B))
    Binding Specificity
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 9-121
    Reactivity
    • 40
    • 15
    • 14
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 37
    • 2
    • 1
    Mouse
    Clonality
    • 40
    Monoclonal
    Conjugate
    • 19
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This VTI1B antibody is un-conjugated
    Application
    • 27
    • 22
    • 5
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Human, Rat (Rattus)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse Vti1b aa. 9-121
    Clone
    7-Vti1b
    Isotype
    IgG1
    Top Product
    Discover our top product VTI1B Primary Antibody
  • Comment

    Related Products: ABIN968536, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Chen, Manga, Orlow: "Pink-eyed dilution protein controls the processing of tyrosinase." in: Molecular biology of the cell, Vol. 13, Issue 6, pp. 1953-64, (2002) (PubMed).

    Mallard, Tang, Galli, Tenza, Saint-Pol, Yue, Antony, Hong, Goud, Johannes: "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform." in: The Journal of cell biology, Vol. 156, Issue 4, pp. 653-64, (2002) (PubMed).

    Shorter, Beard, Seemann, Dirac-Svejstrup, Warren: "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115." in: The Journal of cell biology, Vol. 157, Issue 1, pp. 45-62, (2002) (PubMed).

    Yang, Gonzalez, Prekeris, Steegmaier, Advani, Scheller: "SNARE interactions are not selective. Implications for membrane fusion specificity." in: The Journal of biological chemistry, Vol. 274, Issue 9, pp. 5649-53, (1999) (PubMed).

    Advani, Bae, Bock, Chao, Doung, Prekeris, Yoo, Scheller: "Seven novel mammalian SNARE proteins localize to distinct membrane compartments." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10317-24, (1998) (PubMed).

  • Target
    VTI1B (Vesicle Transport through Interaction with T-SNAREs Homolog 1B (VTI1B))
    Alternative Name
    Vti1b (VTI1B Products)
    Synonyms
    VTI1 antibody, VTI1-LIKE antibody, VTI1L antibody, VTI2 antibody, v-SNARE antibody, vti1-rp1 antibody, AU015348 antibody, GES30 antibody, MVti1b antibody, SNARE antibody, Vti1-rp1 antibody, zgc:63525 antibody, VTI1B antibody, vesicle transport through interaction with t-SNAREs 1B antibody, vesicle transport through interaction with t-SNAREs 1B pseudogene antibody, VTI1B antibody, Vti1b antibody, vti1b antibody, LOC461624 antibody
    Background
    Eukaryotic protein trafficking involves packaging of target molecules into membranous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their contents into an acceptor compartment. Recognition between vesicle and acceptor membrane is mediated by the pairing of the integral membrane SNARE proteins. The stable interaction between vesicle proteins (v-SNAREs, VAMP1, VAMP2) and target proteins (t-SNAREs, syntaxin 1, SNAP-25) juxtaposes the membranes and results in an activated docked state and/or membrane fusion. With the identification of all SNARE family members in yeast, the research focus has turned to mammalian cells. Here, sequence analysis has identified additional SNARE proteins, including VTI1a and VTI1b. In line with their involvement in vesicle transport, these molecules are expressed in a wide range of mammalian tissues. VTI1b is a membrane bound protein whose localization overlaps with the cis/medial Golgi marker mannosidase II and the trans-Golgi marker syntaxin 6. VTI1b interacts with, and disrupts the localization of, syntaxin 5. Thus, VTI1b is thought to function in the regulation of post-Golgi vesicle trafficking.
    Molecular Weight
    27 kDa
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