LPA antibody

Catalog No. ABIN969261

Product Details anti-LPA Antibody

Target: LPA (APOA) (Apolipoprotein A (APOA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LPA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: purified

Immunogen: Purified recombinant fragment of LPA (4330-4521) expressed in E. coli.

Clone: 8F6A9

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-LPA antibody (ABIN969261)

Ranga, Kalra, Tandon, Gambhir, Mehrotra: "Effect of aspirin on lipoprotein(a) in patients with ischemic stroke." in: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 16, Issue 5, pp. 220-4, (2007) (PubMed).

Catalano, Cortelazzo, Yilmaz, Perilli, Carzaniga, Emanuele: "The LPA gene C93T polymorphism influences plasma lipoprotein(a) levels and is independently associated with susceptibility to peripheral arterial disease." in: Clinica chimica acta; international journal of clinical chemistry, Vol. 387, Issue 1-2, pp. 109-12, (2007) (PubMed).

Target Details for LPA

Target: LPA (APOA) (Apolipoprotein A (APOA))

Alternative Name: LPA (APOA Products)

Synonyms: AK38 antibody, APOA antibody, LP antibody, Apo(a) antibody, Lp(a) antibody, lipoprotein(a) antibody, LPA antibody

Background:

Description: LPA: lipoprotein, Lp(a). Apo(a) is the main constituent of lipoprotein(a) (lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1.Lp(a) may be a ligand for megalin/gp 330.Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-lp(a).Apo(a) fragments accumulate in atherosclerotic lesions,where they may promote thrombogenesis.O-glycosylation may limit the extent of proteolytic fragmentation.

Aliases: LP, AK38, APOA, LPA

Gene ID: 4018

HGNC: 4018