PTK7 antibody

Catalog No. ABIN969374

Product Details anti-PTK7 Antibody

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTK7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: purified

Immunogen: Purified recombinant fragment of human PTK7 expressed in E. coli.

Clone: 4F9

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-PTK7 antibody (ABIN969374)

Shin, Maeng, Jung, Min, Kwon, Lee: "Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis." in: Biochemical and biophysical research communications, Vol. 371, Issue 4, pp. 793-8, (2008) (PubMed).

Target Details for PTK7

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Alternative Name: PTK7 (PTK7 Products)

Synonyms: PTK7 antibody, CCK-4 antibody, CCK4 antibody, Srf antibody, 8430404F20Rik antibody, chz antibody, mPTK7/CCK4 antibody, KLG antibody, protein tyrosine kinase 7 (inactive) antibody, protein tyrosine kinase 7 antibody, PTK7 protein tyrosine kinase 7 antibody, PTK7 antibody, Ptk7 antibody

Background:

Description: Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.

Aliases: CCK4, PTK7

Molecular Weight: 118 kDa

Gene ID: 5754

HGNC: 5754

Pathways: RTK Signaling, Tube Formation