TRKA antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (AA 33-423)

Details for Product anti-NTRK1 Antibody No. ABIN969444
Antigen
Epitope
AA 33-423
74
33
27
21
19
17
16
15
15
15
12
12
12
12
10
10
9
9
7
6
6
6
5
5
4
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
453
293
235
2
2
Host
Mouse
444
40
4
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This TRKA antibody is un-conjugated
27
17
17
17
17
17
16
16
16
10
9
9
7
7
7
7
7
2
2
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
274
179
120
88
56
48
40
32
19
8
5
4
4
3
1
Options
Immunogen Purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
Clone 6B2
Isotype IgG1
Purification Ascites
Antigen
Alternative Name TrkA (NTRK1 Antibody Abstract)
Background TrkA, also known as NTRK1, MTC, TRK, TRK1. It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Molecular Weight 87.4 kDa
Gene ID 4914
HGNC 4914
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-423) antibody (ABIN969444) Figure 1: Confocal immunofluorescence analysis of PC-12 cells using TrkA mouse mAb (g...
Image no. 2 for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-423) antibody (ABIN969444) Figure 2: Western blot analysis using TrkA mouse mAb against extracellular domain of ...
Product cited in: Geetha, Wooten: "TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent." in: Traffic (Copenhagen, Denmark), Vol. 9, Issue 7, pp. 1146-56, 2008 (PubMed).

Schulte, Kuhfittig-Kulle, Klein-Hitpass, Schramm, Biard, Pfeiffer, Eggert: "Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells." in: DNA repair, Vol. 7, Issue 10, pp. 1757-64, 2008 (PubMed).