Class II, Major Histocompatibility Complex, Transactivator (CIITA) (N-Term) antibody

Details for Product No. ABIN97340
Antigen
Epitope
N-Term
15
4
3
2
2
1
1
1
1
1
1
Reactivity
Human
42
30
28
5
2
2
2
1
1
1
Host
Rabbit
43
3
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
Application
ELISA
39
23
7
7
5
4
2
1
1
Options
Immunogen Anti-CIITA was produced by repeated immunizations with CIITA peptide corresponding to a region near the of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Isotype IgG
Characteristics Concentration Definition: by UV absorbance at 280 nm
Purification Antiserum
Antigen
Alternative Name CIITA (CIITA Antibody Abstract)
Background Anti-CIITA antibody detects CIITA. The transactivator CIITA regulates basal and interferon-induced expression of Major Histocompatibility Complex class II genes. CIITA restores expression of all MHC class II gene expression in mutant cells and corrects regulatory defects of MHC class II genes. Antibodies to this transactivator are useful in the study of diseases of pathological MHC class II expression. Antigen can be obtained from Raji cell lysates. Typically levels of CIITA expression are too low to detect endogenous levels of protein expression. Transiently transfected cells are usually employed to study this transcription factor.
Synonyms: MHC class II transactivator type III antibody, MHC2TA antibody, NLR family acid domain containing antibody, NLRA antibody, Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing antibody
Gene ID 4261
UniProt P33076
Pathways Cancer Immune Checkpoints
Application Notes Anti-CIITA is suitable for the detection by immunoblot of human CIITA and ELISA.
Restrictions For Research Use only
Format Liquid
Concentration 2.2 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C