Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (C-Term) antibody

Details for Product No. ABIN97991
Antigen
Epitope
C-Term
32
16
15
15
8
8
7
7
7
6
5
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
179
86
73
11
10
3
3
2
1
Host
Rabbit
160
37
3
Clonality
Polyclonal
Conjugate
Un-conjugated
10
9
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
1
1
Application
ELISA, Western Blotting (WB)
143
75
58
42
32
26
16
11
10
9
8
3
2
2
2
1
Options
Immunogen This whole rabbit serum was prepared by repeated immunizations with a fusion protein corresponding to the carboxy-terminus of human Cox-2.
Immunogentype:Recombinant
Characteristics Concentration Definition: by Refractometry
Purification Antiserum
Antigen
Alternative Name Cox-2 (PTGS2 Antibody Abstract)
Background COX-2, also known as prostaglandin H synthase, was identified less than a decade ago.  Its discovery was followed by a period of discovery and drug development to create a “super aspirin” and led to insights into arthritis, Alzheimer's disease, colorectal cancer and regulation of brain and kidney function in search of better treatments for degenerative and inflammatory diseases.   Two different isoforms of the enzyme are known, Cox-1 and  Cox and Cox-2.
Synonyms: Prostaglandin G/H synthase 2 antibody, Cyclooxygenase-2 antibody, Prostaglandin-endoperoxide synthase 2 antibody, Prostaglandin H2 synthase 2 antibody, PGH synthase 2 antibody, PGHS-2 antibody
Gene ID 5743
UniProt P35354
Pathways Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Application Notes Cox-2 (Cyclooxygenase-2) is an inducible enzyme that is normally absent from cells, however, in response to growth factors, tumor promoters and some cytokines, it undergoes a rapid and transient expression.  This antiserum against Human Cox-2 and has been tested for use in immunoblotting and ELISA.  The antibody recognizes Cox-2 at 70kDa in Sf9 cell lines transfected with Cox-2 as well as in WISH cells induced with IL-1b.  Reactivity in other immunoassays is unknown.
Restrictions For Research Use only
Format Liquid
Concentration 55 mg/mL
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Image no. 1 for anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (C-Term) antibody (ABIN97991) anti-Cox2 is shown to detect Cox-2 present in Cox-2 transfected Sf9 cell extract (lan...
Product cited in: Tong, Tai: "Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells." in: Biochemical and biophysical research communications, Vol. 276, Issue 1, pp. 77-81, 2000 (PubMed).

Guan, Buckman, Miller, Springer, Morrison: "Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells." in: The Journal of biological chemistry, Vol. 273, Issue 44, pp. 28670-6, 1998 (PubMed).