General
Antigen
Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) Antibodies
Reactivity
Human, Mouse (Murine), Monkey, Rat (Rattus)
Alternatives
Host
Mouse
Alternatives
Clonality
Conjugate
This AIFM1 antibody is un-conjugated
Alternatives
Application
ELISA, Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC), Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
Supplier
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Purification
Ascitic fluid containing 0.03% sodium azide.
Immunogen
Purified recombinant fragment of human AIF expressed in E. Coli.
Isotype
IgG2b
Antigen
Alternative Name
AIF (AIFM1 Antibody Abstract )
Background
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
Molecular Weight
67 kDa
Pathways
Apoptosis , Positive Regulation of Endopeptidase Activity , Cell RedoxHomeostasis , Smooth Muscle Cell Migration
Restrictions
For Research Use only
Format
Liquid
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot and store at -20 °C.
Supplier Images
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 2)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 3)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 4)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 5)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 6)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 7)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 8)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 2)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 3)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 4)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 5)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 6)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 7)
anti-Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) antibody (Image 8)