We are preparing the requested document. Please wait, this may take a while...!
|Antigen||BCL2-Like 1 (BCL2L1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This BCL2L1 antibody is un-conjugated Alternatives|
Immunoprecipitation (IP), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-BCL2L1 AntibodyTarget Details BCL2L1 Application Details Handling References for anti-BCL2L1 antibody (ABIN223050) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412611|
The antibody detects the 30 kDa Bcl-xL protein.
It does not react with other Bcl-2 family members.
|Immunogen||Synthetic peptide surrounding amino acid 56 of human Bcl-xL|
Target Details BCL2L1Product Details anti-BCL2L1 Antibody Application Details Handling References for anti-BCL2L1 antibody (ABIN223050) Images back to top
|Alternative Name||Bcl-XL (BCL2L1 Antibody Abstract)|
Bcl-xL is a 30 kDa anti-apoptotic protein belonging to the Bcl-2 family. Bcl-xL prevents apoptosis throμgh two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. Bcl-xL can be cleaved by caspases upon apoptotic activation, which converts Bcl-xL from an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of Bcl-xL forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway.
Synonyms: Bcl-xL, Bcl-xS, BCL2L1, BCL2-like 1 protein
|Pathways||Apoptosis, Negative Regulation of intrinsic apoptotic Signaling|
Application DetailsProduct Details anti-BCL2L1 Antibody Target Details BCL2L1 Handling References for anti-BCL2L1 antibody (ABIN223050) Images back to top
|Application Notes||Western blotting (0.5-4 μg/mL) and immunoprecipitation (20 μ/mL). However, the optimal conditions should be determined individually. The antibody detects the 30 kDa Bcl-xL protein. It does not react with other Bcl-2 family members.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-BCL2L1 Antibody Target Details BCL2L1 Application Details References for anti-BCL2L1 antibody (ABIN223050) Images back to top
|Buffer||100 μg (0.5 mg/mL) affinity purified, rabbit anti-Bcl-xL polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||The antibody solution should be gently mixed before use.|
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-BCL2L1 antibody (ABIN223050)Product Details anti-BCL2L1 Antibody Target Details BCL2L1 Application Details Handling Images back to top
|Product cited in:||
Cordiali-Fei, Ardigo, Mastroianni, Giuliani, D Agosto, Bordignon, Trento, Vento, Berardesca: "Serum cytokines and biohumoral immunological characterization of psoriatic patients in long term etanercept treatment." in: International journal of immunopathology and pharmacology, Vol. 21, Issue 3, pp. 643-50, 2008
Dakhova, ODay, Kinet, Yucer, Wiese, Shetty, Ducy: "Dickkopf-like1 regulates postpubertal spermatocyte apoptosis and testosterone production." in: Endocrinology, Vol. 150, Issue 1, pp. 404-12, 2008
Giuliani, Mioni, Altavilla, Leone, Bazzani, Minutoli, Bitto, Cainazzo, Marini, Zaffe, Botticelli, Pizzala, Savio, Necchi, Schiöth, Bertolini, Squadrito, Guarini: "Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia." in: Endocrinology, Vol. 147, Issue 3, pp. 1126-35, 2006
ImagesProduct Details anti-BCL2L1 Antibody Target Details BCL2L1 Application Details Handling References for anti-BCL2L1 antibody (ABIN223050) back to top