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anti-Human BIRC2 Antibodies:
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Human Polyclonal BIRC2 Primary Antibody for IHC (p), WB - ABIN541230
Rothe, Pan, Henzel, Ayres, Goeddel: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. in Cell 1996
Show all 3 Pubmed References
Dog (Canine) Polyclonal BIRC2 Primary Antibody for IHC (fro), IHC (p) - ABIN537405
Lin, Chang, Ho, Huang: Ischemic preconditioning reduces neurovascular damage after hypoxia-ischemia via the cellular inhibitor of apoptosis 1 in neonatal brain. in Stroke; a journal of cerebral circulation 2012
Dog (Canine) Polyclonal BIRC2 Primary Antibody for IHC (fro), IHC (p) - ABIN4298716
Chui, Ma, Li, Xu, Yao, Lin, Chan, Lee: Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells. in Apoptosis : an international journal on programmed cell death 2014
study provides an interesting example using chemical biological approaches for determining distinct biological consequences from inhibiting vs. activating an E3 ubiquitin ligase and suggests a potential broad therapeutic strategy for targeting c-MYC in cancer treatment by pharmacologically modulating cIAP1 E3 ligase activity.
We further identified this underlying mechanism also involved a PPARgamma-induced ANXA1-dependent autoubiquitination of cIAP1, the direct E3 ligase of RIP1, shifting cIAP1 toward proteosomal degradation..our study provides first insight for the suitability of using drug-induced expression of ANXA1 as a new player in RIP1-induced death machinery in triple-negative breast cancer
NAIP expression is most abundant in M2 macrophages, while cIAP1 and cIAP2 show an inverse pattern of expression in polarized cells, cIAP2 is preferentially expressed in M1-macrophages and cIAP1 in M2-macrophages. IAP antagonist treatment of resting M0 macrophages preceding polarization stimulation, induced upregulation of NAIP in M2 and downregulation of cIAP1 in M1 and M2 but an induction of cIAP2 in M1 macrophages.
we conclude that DMBT1 by binding with CRNDE and c-IAP1 associated with PI3K-AKT pathway is crucial for GBC carcinogenesis, and targeting this pathway may be pivotal in the treatment of GBC.
These results reveal an additional level of regulation of the stability and the activity of E2F1 by a non-degradative K63-poly-ubiquitination and uncover a novel function for the E3-ubiquitin ligase cIAP1.
High cIAP1 expression is associated with colorectal cancer.
the cytoplasmic retinoic acid receptor gamma (RARgamma) controls receptor-interacting protein kinase 1 (RIP1)-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked.
High cIAP1 expression is associated with Lung Tumorigenesis.
These data suggest that molluscum contagiosum virus MC159 competitively binds to NEMO to prevent cIAP1-induced NEMO polyubiquitination.
The baseline tumor necrosis factor tumor (TNFalpha) expression correlates with the sensitivity to Inhibitors of apoptosis proteins (IAPs) antagonist T-3256336.
cIAP1-induced mitophagy led to dysfunctional mitochondria that resulted in abrogation of mitochondrial oxygen consumption rate along with the decrease in ATP levels. The ubiquitination of cIAP1 was found to be the critical regulator of mitophagy.
Overexpression of cIAP1 is associated with glioma.
High expression of cIAP1 is associated with triple-negative breast cancer.
cIAP1 and cIAP2 mediate BCL10 ubiquitination essential for BCR-dependent NF-kB activity in the ABC subtype of DLBCL. cIAP1/2 attach K63-linked polyubiquitin chains on themselves and on BCL10, recruiting IKK and LUBAC essential for IKK activation.
AZD5582 draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer
Data indicate that Smac/DIABLO showed an inverse correlation with inhibitor of apoptosis proteins XIAP, cIAP-1 and cIAP-2.
Data show that ectopic expression of interferon regulatory factor 1 (IRF-1) reduces NF-kappa B activity and suppresses TNF receptor-associated factor 2 (TRAF2) and inhibitor of apoptosis 1 protein (cIAP1) expression in breast cancer cells.
cIAP1 is associated with tumor progression in human ovarian cancer.
The E3 ubiquitin ligase activity of XIAP and cIAP1 activates NFkappaB signalling, leading to the direct binding of p65 to the promoter of Beclin 1 and to its transcriptional activation and induction of autophagy.
CIAP1 and cIAP2 represent novel therapeutic targets for the prevention of spontaneous preterm birth.
Drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNFalpha.
Results identify IGF2BP1 as a critical translational regulator of cIAP1-mediated apoptotic resistance in rhabdomyosarcoma.
Identify xIAP and cIAP1 as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.
NFATc1 mRNA expression is negatively regulated by inhibitor of apoptosis protein 2 during osteoclastogenesis.
cIAP1 expression protects macrophages from Rip1-dependent necroptotic cell death and facilitates pathogen control.
cIAP1 plays a critical role in beta-cell survival under endoplasmic reticulum stress: by promoting ubiquitination and degradation of C/EBP homologous protein (CHOP)
Deficiency in cIAP1 (encoded by Birc2) or cIAP2 (Birc3) impaired caspase-1 activation after spontaneous or agonist-induced inflammasome assembly.
fundamental role for cIAP1/cIAP2 in regulating B-cell survival and responsiveness
These findings identify critical role of cIAP1, cIAP2 and Yap1 co-expression in mammary carcinogenesis
Murine IAP1 is alternatively spliced at intron 6-7, generating protein isoforms with significantly different functional properties compared to the full-length mIAP1, in vitro.
Data show that apoptosis caused by an IAP antagonist compound is blocked by the caspase 8 inhibitor crmA and that IAP antagonists activate NF-kappaB signaling via inhibtion of cIAP1.
Elevation of c-IAP1 levels at a posttranscriptional step was detectable in MCF13 MLV-induced thymic lymphomas and chronically infected mink epithelial cells.
Lysosomal degradation of cIAP1-TRAF2 by TWEAK/FN14 therefore critically alters the balance of life/death signals emanating from TNF-R1 in immortalized cells.
c-IAP1 and c-IAP2 are required for TNFalpha-stimulated RIP1 ubiquitination and NF-kappaB activation.
PERK activity inhibits the ER stress-induced apoptotic program through the induction of cellular inhibitor of apoptosis (cIAP1 and cIAP2) proteins
MMP13 expression enhances osteosarcoma cell survival and Birc2 and Birc3 enhance cell survival but only in osteosarcoma cells with the chromosome 9A1 amplicon. The genes Birc2 and Birc3 are potential oncogenic drivers in the chromosome 9A1 amplicon.
cIAP1 and cIAP2 are E3 ubiquitin ligases that are required for receptor-interacting protein 2 ubiquitination and for nucleotide-binding and oligomerization signaling.
The autoubiquitination of c-IAP1 is blocked upon coexpression with TNF receptor-associated factor (TRAF) 2, and this is achieved by inhibition of the E3 ubiquitin ligase activity intrinsic to the RING of c-IAP1.
TRAF2 has anti-apoptotic signaling roles in addition to promoting NF-kappaB signaling and that efficient activation of NF-kappaB by TNFR1 requires the recruitment of cIAP1/2 by TRAF2.
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
IAP homolog B
, NFR2-TRAF signalling complex protein
, RING finger protein 48
, TNFR2-TRAF-signaling complex protein 2
, apoptosis inhibitor 1
, baculoviral IAP repeat-containing 2
, baculoviral IAP repeat-containing protein 2
, inhibitor of apoptosis protein 2
, apoptosis inhibitor 2
, inhibitor of apoptosis protein
, IAP homolog
, inhibitor of T-cell apoptosis protein
, inhibitor of apoptosis 1
, baculoviral IAP repeat-containing 3
, inhibitor of apoptosis protein-1
, inhibitor of apoptosis protein 1
, bZ1P14.6.2 (baculoviral IAP repeat-containing 3 )
, baculoviral IAP repeat containing 2 L homeolog