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|Antigen||Baculoviral IAP Repeat-Containing 5 (BIRC5) Antibodies|
|Epitope||AA 121-142, C-Term Alternatives|
|Conjugate||This BIRC5 antibody is un-conjugated Alternatives|
Western Blotting (WB)
|6 references available|
|Supplier||Log in to see|
Product Details anti-BIRC5 AntibodyTarget Details BIRC5 Application Details Handling References for anti-BIRC5 antibody (ABIN3043195) Images
|Purpose||Rabbit IgG polyclonal antibody for Baculoviral IAP repeat-containing protein 5(BIRC5) detection. Tested with WB in Human.|
|Sequence||KKEFEETAKK VRRAIEQLAA MD|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Baculoviral IAP repeat-containing protein 5(BIRC5) detection. Tested with WB in Human.
Gene Name: baculoviral IAP repeat containing 5
Protein Name: Baculoviral IAP repeat-containing protein 5
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human survivin(121-142aa KKEFEETAKKVRRAIEQLAAMD).|
|Plasmids, Primers & others|
Target Details BIRC5Product Details anti-BIRC5 Antibody Application Details Handling References for anti-BIRC5 antibody (ABIN3043195) Images back to top
|Alternative Name||BIRC5 (BIRC5 Antibody Abstract)|
Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis(IAP) family. The survivin gene contains 4 exons. The survivin gene is mapped to chromosome 17q25 by pulsed field gel electrophoresis and single- and 2-color FISH. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.
Synonyms: API4 antibody|Apoptosis Inhibitor 4 antibody|Apoptosis inhibitor survivin antibody|Apoptosis inhibitor4 antibody|Baculoviral IAP repeat containing 5 antibody|Baculoviral IAP repeat containing protein 5 antibody|Baculoviral IAP repeat-containing protein 5 antibody|BIRC 5 antibody|BIRC5 antibody|EPR 1 antibody|IAP4 antibody|Survivin variant 3 alpha antibody|SVV antibody|TIAP antibody
|Pathways||Apoptosis, Cell Division Cycle|
Application DetailsProduct Details anti-BIRC5 Antibody Target Details BIRC5 Handling References for anti-BIRC5 antibody (ABIN3043195) Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
|Restrictions||For Research Use only|
HandlingProduct Details anti-BIRC5 Antibody Target Details BIRC5 Application Details References for anti-BIRC5 antibody (ABIN3043195) Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|Preservative||Thimerosal (Merthiolate), Sodium azide|
|Precaution of Use||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
|Expiry Date||12 months|
References for anti-BIRC5 antibody (ABIN3043195)Product Details anti-BIRC5 Antibody Target Details BIRC5 Application Details Handling Images back to top
|Product cited in:||
Li, Zhao, Lu, Li, Yang, Wu, Liu: "Notch-1 signaling promotes the malignant features of human breast cancer through NF-?B activation." in: PLoS ONE, Vol. 9, Issue 4, pp. e95912, 2014
Zhang, Lu, Hou, Hu, Wang: "The effects of STAT3 and Survivin silencing on the growth of human bladder carcinoma cells." in: Tumour biology, Vol. 35, Issue 6, pp. 5401-7, 2014
Hao, Huang, Liao, Zhu, Liu, Hao, Liu, Zhang, Feng, Ning, Li, Li: "The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice." in: Fitoterapia, Vol. 86, pp. 84-91, 2013
Li, Zhang, Fang, Yan, Zhao, Feng, Ma, Ye: "Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1." in: Biochemical and biophysical research communications, Vol. 434, Issue 4, pp. 809-14, 2013
Cai, Liu, Zhao, Wan, Hu, Zhou, Chen: "Expressions of survivin and vascular endothelial growth factor in a Murine model of proliferative retinopathy." in: International journal of ophthalmology, Vol. 5, Issue 3, pp. 293-6, 2012
Shan, Zhang, Geng, Zhou, Chen, Nie, Guo, Li, Liu, Guo, Wei, Chen: "Expression of survivin and human telomerase reverse transcriptase in extramammary Paget's disease." in: Journal of cutaneous pathology, Vol. 37, Issue 6, pp. 635-40, 2010
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