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|Antigen||Baculoviral IAP Repeat-Containing 5 (BIRC5) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This BIRC5 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-BIRC5 AntibodyTarget Details BIRC5 Application Details Handling Images
|Specificity||This antibody detects IAP4 / BIRC5 at C-term.|
|Cross-Reactivity (Details)||Species reactivity (tested):Mouse|
|Purification||Peptide affinity chromatography|
|Immunogen||Survivin antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of mouse Survivin.|
Target Details BIRC5Product Details anti-BIRC5 Antibody Application Details Handling Images back to top
|Alternative Name||IAP4 / BIRC5 (BIRC5 Antibody Abstract)|
|Background||Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP (1-3). Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (1,3).Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin|
|Pathways||Apoptosis, Cell Division Cycle|
Application DetailsProduct Details anti-BIRC5 Antibody Target Details BIRC5 Handling Images back to top
ELISA. Western blot: 1 to 2 μg/mL, an approximate 17 kDa band can be detected. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-BIRC5 Antibody Target Details BIRC5 Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|