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Survivin expression in tumor tissue and its serum concetration significantly correlate with clinical and histopathological parameters in melanoma patients.
Data suggest that KLF4 (show KLF4 Proteins) could promote cell senescence through a complex network: miR (show MLXIP Proteins)-203, survivin, and p21 (show CDKN1A Proteins), which were all regulated by overexpression of KLF4 (show KLF4 Proteins) and contributed to cell senescence.
The high sensitivity, specificity, and accuracy of serum and aqueous humor survivin and TGF-B1 proteins make them promising markers for early detection and follow-up of RB patients.
increased expression of both DNA methytransferase I (DNMT1 (show DNMT1 Proteins)) and Survivin was observed and significantly correlated with the reduced miR (show MLXIP Proteins)-203 in NSCLC
ablation of Glut1 (show SLC2A1 Proteins) attenuated apoptosis and increased drug resistance via upregulation of p-Akt (show AKT1 Proteins)/p-GSK-3beta (Ser9)/beta-catenin (show CTNNB1 Proteins)/survivin.
Nuclear survivin expression correlates with endoglin (show ENG Proteins)-assessed microvascularisation in laryngeal squamous cell carcinoma.
survivin expression modes and YAP (show YAP1 Proteins) localization (Hippo pathway activation modes) were not correlated with survival. In addition, we confirmed that survivin small interference RNA (siRNA) transfection and YM155, an anti-survivin drug, elicited decreased nuclear survivin expression and cell proliferation in ISO-HAS-B cells which expressed survivin consistently
Survivin expression in lung squamous cell carcinoma was increased compared to normal tissue, and was unaffected by methylation status of the surviving gene.
Survivin gene promoter methylation was more frequent in gastric cancer patients than in controls.
These findings uncover the significance of Merlin (show NF2 Proteins) protein expression and Survivin labeling index as prognosticators for poor clinical outcome in two independent Malignant pleural mesothelioma cohorts.
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation.
HDL (show HSD11B1 Proteins)-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 (show STAT3 Proteins) activity and survivin expression.
Survivin also attenuates DNA damage related to PARP (show PARP1 Proteins) activation and inhibits TNFalpha (show TNF Proteins)-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (show TGFB1 Proteins) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (show GUSB Proteins) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (show WNT2 Proteins) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 Proteins)) cancer stem cell formation and cancer SCC (show CYP11A1 Proteins) development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (show BCL2 Proteins) and ki67 (show MKI67 Proteins).
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)-like
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha