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anti-Mouse (Murine) CAPN2 Antibodies:
anti-Human CAPN2 Antibodies:
anti-Rat (Rattus) CAPN2 Antibodies:
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Results indicate that calpain-1 (show CAPN1 Antibodies) and calpain-2 are differentially activated in hippocampus following seizure activity, with calpain-1 (show CAPN1 Antibodies) activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 is widely activated in pyramidal neurons of CA1 (show CA1 Antibodies) and CA3 (show CA3 Antibodies), and triggers neurodegenerative cascades.
these findings identify ASAP2 (show ASAP2 Antibodies) as a new target of Selk (show HSP Antibodies)-dependent palmitoylation and reveal a new mechanism regulating the efficiency of FcgammaR-mediated phagocytosis.
ENaC (show SCNN1A Antibodies) activity is regulated by calpain-2 proteolysis of MARCKS (show MARCKS Antibodies).
calpains and calpastatin (show CAST Antibodies) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Antibodies)-5HTT (show SLC6A4 Antibodies)(+) strain) PH, were investigated.
Leukocyte calpain-1 (show CAPN1 Antibodies)/calpain-2 deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.
These results suggest that TRPV1 (show TRPV1 Antibodies)/Ca(2 (show CA2 Antibodies)+)/calpain 2-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors.
Calpain-2 modulates pulmonary vascular remodeling in pulmonary arterial hypertension.
LOX-1 (show OLR1 Antibodies) is, at least in part, responsible for the inhibitory effect of ox-LDL on macrophage migration and this process involves calpain-1 (show CAPN1 Antibodies) and -2.
Dicer is predominantly (show CA2 Antibodies) a Capn2 substrate. Dicer levels were altered in platelets from diabetic mice due to the cleavage (show DICER1 Antibodies) of the enzyme by calpain, resulting in loss of function.
Data suggest that vitamin D3 up-regulates skeletal muscle fat deposition, up-regulates muscle m-calpain/Capn2 and u-calpain/Capn1 expression, and down-regulates muscle calpastatin expression.
m-calpain translocated as the result of calcium influx was involved in DNA double-strand breaks repair, especially in the non-homologous end-joining pathway through proteolysis of nuclear Ku80. Cleaved Ku80 was still able to form a heterodimer with Ku70 and enhance DNA repair activity.
3 novel loci associated with serum alpha-carotene concentrations among a population that consumed a controlled diet. While replication is necessary, the CAPN2/CAPN8 (show CAPN8 Antibodies) locus provides compelling evidence for an association with serum alpha-carotene concentrations and may suggest a relationship with the development and progression of cancers.
The inhibitory effects of BMP4 (show BMP4 Antibodies) on PDGF (show PDGFA Antibodies)-induced cell proliferation, collagen synthesis, and calpain-2 activation are impaired in pulmonary artery smooth muscle cells from pulmonary arterial hypertension patient.
Calpain-2 upregulates PDGF (show PDGFA Antibodies)-induced Akt (show AKT1 Antibodies) phosphorylation in pulmonary vascular remodeling via an intracrine TGF-beta1 (show TGFB1 Antibodies)/mTORC2 (show CRTC2 Antibodies) mechanism.
the expression of CAPN2 was elevated in prostate cancer tissues than that in normal control tissues.
our findings suggest that the gene/protein expression of both CAPN1 (show CAPNL1 Antibodies) and CAPN2, as well as the ERK1 (show MAPK3 Antibodies) and ERK2 (show MAPK1 Antibodies) genes and related proteins, could be molecular factors associated with more invasive tumor behavior in squamous cell laryngeal cancer.
Calpain 2-mediated cleavage of Atg3 (show ATG3 Antibodies) and Atg7 (show ATG7 Antibodies) accounts for the impaired autophagy.
Calcineurin together with its upstream molecule, calpain 2, and its downstream effector, NFAT (show NFATC1 Antibodies)-c3, might contribute to the development of atrial fibrillation in patients with heart valve disease and diabetes.
m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores.
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3 (show UCP3 Antibodies)/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
The cleavage of NCX1 (show SLC8A1 Antibodies) by m-calpain in the caveolae vesicles may be interpreted as an important mechanism of Ca(2 (show CA2 Antibodies)+) overload
characteristic properties of ER membrane m-calpain (MCp (show CD46 Antibodies)), calpastatins and lumen m-calpain (LCp (show KLHDC2 Antibodies)) and a brief comparative study between MCp (show CD46 Antibodies) and LCp (show KLHDC2 Antibodies)
Calpain-2 plays an important role in lung endothelial cell migration and proliferation.
The Decreased expression of calpain 2 mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene.
80 kDa M-calpain subunit
, CANP 2
, calcium-activated neutral proteinase 2
, calpain M-type
, calpain-2 catalytic subunit
, calpain-2 large subunit
, cysteine proteinase
, m-calpain 80 kDa large subunit
, m-calpain large subunit
, calpain 2, large [catalytic] subunit
, calpain 2, large subunit
, calpain large polypeptide L2
, calpain, large polypeptide L2
, calpain II