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anti-Mouse (Murine) CAPNL1 Antibodies:
anti-Human CAPNL1 Antibodies:
anti-Rat (Rattus) CAPNL1 Antibodies:
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Human Polyclonal CAPNL1 Primary Antibody for IHC (p), WB - ABIN3043467
Chen, Tang, Gao, Xu, Jiang, Cao, Fu, Sun, Liu, Shi: Fibrosis, adipogenesis, and muscle atrophy in congenital muscular torticollis. in Medicine 2014
Show all 2 Pubmed References
Human Polyclonal CAPNL1 Primary Antibody for ICC, IHC (fro) - ABIN3044292
Mo, Chen, Li, Zheng, Ke, Deng, Li, Jiang, Wu, Wang, Wang, Yang, Cao: Suppression of NHE1 by small interfering RNA inhibits HIF-1?-induced angiogenesis in vitro via modulation of calpain activity. in Microvascular research 2011
Show all 2 Pubmed References
indicate that calpain-1 (show CAPN1 Antibodies) and calpain-2 (show CAPN2 Antibodies) play opposite roles in high increased intraocular pressure-induced ischemic injury
Results strengthen the roles of both calpain-1 (show CAPN1 Antibodies) and PHLPP1 (show PHLPP1 Antibodies) in synaptic plasticity and learning and memory, and illustrate the complexities of the interactions between multiple pathways participating in synaptic plasticity.
Genetic ablation of calpain-1 (show CAPN1 Antibodies) ameliorates chronic pain behavior in sickle cell mice.
Our results indicate that calpain mediates cytokine-induced collagen-I synthesis and proliferation of ASMCs via the mTORC2 (show CRTC2 Antibodies)/Akt (show AKT1 Antibodies) signalling pathway, thereby regulating airway smooth muscle remodelling in asthma.
mutations in CAPN1 are an additional cause of ataxia in mammals, including humans.
Results indicate that calpain-1 (show CAPN1 Antibodies) and calpain-2 (show CAPN2 Antibodies) are differentially activated in hippocampus following seizure activity, with calpain-1 (show CAPN1 Antibodies) activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 (show CAPN2 Antibodies) is widely activated in pyramidal neurons of CA1 (show CA1 Antibodies) and CA3 (show CA3 Antibodies), and triggers neurodegenerative cascades.
Here we show the combined loss of glial glutamate (show GRIN1 Antibodies) transporters GLT1 (show SLC1A2 Antibodies) and GLAST (show SLC1A3 Antibodies) in spinal cord caused motor neuronal death and hindlimb paralysis.
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
High calpain expression is associated with brain injury.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
Calpain-1 (show CAPN1 Antibodies) was significantly expressed in Triple-negative breast cancer tissues varying from low to high with a significant correlation to lymph node status but not with the other clinicopathological variables, suggesting its role as a prognostic factor
These findings suggest that calpain and AR-V7 may serve as important biomarkers in the treatment of castration-resistant prostate cancer , and targeting calpain and AR-V7 may provide a new approach in overcoming docetaxel-resistance.
Rare homozygous and compound-heterozygous nonsense, missense, frameshift, and splice-site mutations in CAPN1 were identified in all hereditary spastic paraplegia affected individuals, and sequencing in additional family members confirmed the segregation of these mutations with the disease.
the cleavage of myoferlin (show MYOF Antibodies), yielding a membrane-associated dual C2 domain 'mini-myoferlin (show MYOF Antibodies)', is reported.
Calpain-1 (show CAPN1 Antibodies) expression is associated with poor relapse-free survival in breast cancer patients treated with trastuzumab.
Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.
HRNR (show HRNR Antibodies) deimination improves its cross-linking by TGases and its proteolytic processing by calpain-1 (show CAPN1 Antibodies).
calpains and calpastatin (show CAST Antibodies) in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Antibodies)-5HTT (show SLC6A4 Antibodies)(+) strain) PH, were investigated.
calpain and protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies) abnormal release promotes a constitutive release of matrix metalloproteinase 9 (show MMP9 Antibodies) in peripheral blood mononuclear cells from cystic fibrosis (show S100A8 Antibodies) patients
study is the first report on genetic variant g.-1256 A>C in the promoter region of CAPN1 gene association with the semen quality of Chinese Holstein bulls by influencing its expression
This work is supportive of the importance of CAPN1 and CAST for mean tenderness in beef.
Suppression of CANP1 resulted in the activation of caspase (show CASP3 Antibodies) and heat-shock-protein systems which might in turn regulate apoptosis through the caspase (show CASP3 Antibodies)-dependent cell death pathway. [CANP1]
bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1/CAST4 complex structures
This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR (show GHR Antibodies) as a selection marker for beef quality.
It was found that the marker c.3379G > A in the CAPN1 gene influences the Ca content in the meat of this Nelore population, with the rare genotype associated with less Ca content.
m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores.
Association of polymorphisms in calpain 1 (show CAPN1 Antibodies), (mu/I) large subunit, calpastatin (show CAST Antibodies), and cathepsin D (show CTSD Antibodies) genes with meat quality traits in double-muscled Piemontese cattle.
Relationships of the calpain system with meat tenderness and carcass traits were examined for 94 purebred Angus bulls.
The association of polymorphisms in calpastatin (show CAST Antibodies) and mu-calpain genes with meat tenderness in 3 French beef breeds is reported.
CAPN1 HM535412:g.157T > C showed effect on meat redness.
The decreased expression of calpain 1A mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.
Right ventricular (RV) dysfunction from acute RV pressure overload is, in part, due to activation of calpain, and calpain inhibition would therefore attenuate RV dysfunction.
catalytic site amino acid residues 105-133 contained a disulfide bond between Cys (show DNAJC5 Antibodies)(108) and Cys (show DNAJC5 Antibodies)(115)
Association of polymorphisms with breed characteristics indicated that the mutations in CAPN1 detected by P4, P6 primers and that resulting in the change of Hinf 1 recognition site may be related to lean meat percentage.
The activities of Calpain and PLA2 (show YWHAZ Antibodies) on the muscle tissue of the bladders were analyzed.
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
calpain 1, large subunit
, CANP 1
, calcium-activated neutral proteinase 1
, calpain mu-type
, calpain-1 catalytic subunit
, calpain-1 large subunit
, calpain, large polypeptide L1
, cell proliferation-inducing gene 30 protein
, cell proliferation-inducing protein 30
, micromolar calcium activated neutral protease 1
, micromolar calcium-activated neutral protease 1
, mu-calpain large subunit