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|Antigen||Caspase 1 (CASP1) Antibodies|
|Epitope||Intermediate Domain Alternatives|
|Conjugate||This Caspase 1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-Caspase 1 AntibodyTarget Details Caspase 1 Application Details Handling Images
|Specificity||Caspase-1 antibody was raised against a 15 amino acid peptide from near the middle of human Caspase-1.|
|Purification||Affinity chromatography purified via peptide column|
|Immunogen||Human Casp-1 / ICE / IL-1b converting enzyme (Intermediate Domain) Peptide|
|Plasmids, Primers & others|
Target Details Caspase 1Product Details anti-Caspase 1 Antibody Application Details Handling Images back to top
|Alternative Name||Caspase-1 (CASP1 Antibody Abstract)|
|Background||Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1beta and IL-18 (3,4). Caspase-1 was initially identified as an IL-1beta-converting enzyme (5), later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 (6) whose overexpression can induce apoptosis in fibroblasts (7).Synonyms: CASP-1, CASP1, ICE, IL1BC, IL1BCE, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45|
|Pathways||Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity|
Application DetailsProduct Details anti-Caspase 1 Antibody Target Details Caspase 1 Handling Images back to top
ELISA. Western Blot: Casp-1 antibody can be used for the detection of Caspase-1 at 0.5 μg/mL. Depending on cell lines or tissues used, other cleavage products may be observed. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|