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Human Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2487270
Chen, Xia, Fang, Hawke, Lu: Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. in Molecular and cellular biology 2009
Show all 8 Pubmed References
Mouse (Murine) Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2487280
Newman, Leppla, Moayeri: CA-074Me protection against anthrax lethal toxin. in Infection and immunity 2009
Show all 4 Pubmed References
the activation of Rho GTPases by the CNF1 toxin during E. coli-triggered bacteremia leads to a GR1(+)cell-mediated efficient bacterial clearing and improves host survival. Host alarm requires the Caspase-1/IL-1beta (show IL1B Proteins) signaling axis.
Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines and caspase-1 activation
sickle red blood cell induced TLR9 (show TLR9 Proteins), NLRP3 (show NLRP3 Proteins), Caspase-1, IL-1beta (show IL1B Proteins) and IL-18 (show IL18 Proteins) expression and induced IL-1beta (show IL1B Proteins), LTB4 (show PTGR1 Proteins) and nitrite production in PBMC cultures.
Data show that the serine protease inhibitor B9 (serpinB9 (show SERPINB9 Proteins)) mediated caspase-1 inhibition regulates IL-1beta (show IL1B Proteins) release in monocytes.
study uncovers a novel mechanism of G9A (show EHMT2 Proteins) promoting tumor cell growth and invasion by silencing CASP1, and implies that G9A (show EHMT2 Proteins) may serve as a therapeutic target in treating Non-small-cell lung cancer.
Caspase-1 polymorphisms may play a role in Chagas cardiomyopathy development and could serve as markers to identify individuals at higher risk for priority treatment.
besides its role in the inhibition of the NF-kappaB (show NFKB1 Proteins) pathway, NLRC3 interferes with the assembly and activity of the NALP3 (show NLRP3 Proteins) inflammasome complex by competing with ASC (show PYCARD Proteins) for pro-caspase-1 binding
Data, including data from studies using recombinant fusion forms of GSDMD (gasdermin D (show GSDMD Proteins)), suggest that GSDMD (show GSDMD Proteins) participates in inflammasome-dependent pyroptosis of macrophages in response to various stimuli; this mechanism involves proteolysis of GSDMD (show GSDMD Proteins) by caspase-1 and caspase-11 (show CASP4 Proteins).
Proteases caspase-1 and caspase-8 (show CASP8 Proteins) have redundant roles in cleaving IL-1beta (show IL1B Proteins) and promoting osteomyelitis. [review]
Patients with NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome had increased systemic CASP1.
Adult neural stem cells (ANSCs) expressed NLRP3 (show NLRP3 Proteins)-containing inflammasome and alpha-syn activated both TLR4 (show TLR4 Proteins)/NF-kappaB (show NFKB1 Proteins) and NLRP3 (show NLRP3 Proteins)/caspase-1 signals in ANSCs.
dimerized or endogenous caspase-8 (show CASP8 Proteins) can also directly cleave IL-1beta (show IL1B Proteins) into its biologically active form, in the absence of canonical inflammasome components.
Report direct role of pleural cells in the pathogenesis of bleomycin-induced pulmonary fibrosis via caspase-1/IL-1beta (show IL1B Proteins) pathway.
caspase-1-/- mice exhibited resistance to indomethacin-induced small intestinal damage
data provide evidence that the NLRC4 (show NLRC4 Proteins) inflammasome contributes to resistance through regulation of caspase-1, IL-1beta (show IL1B Proteins) and IL-18 (show IL18 Proteins) in a CD11blowLy6Glow population of cells
Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis following lipopolysaccharide exposure through TLR4 (show TLR4 Proteins), which activates Nlrp3 (show NLRP3 Proteins), and subsequently induces caspase-1 activation.
The most well-known function of active caspase-1 is to cleave the proforms of inflammatory cytokines IL-1beta (show IL1B Proteins) and -18 into their active forms in response to inflammatory stimuli in immune cells. Caspase-1 has multiple functions in addition to this cytokine maturation role. It is at the center of many cell responses to stress and inflammation not just in immune cells but in other cell types, such as epithelia. Review.
Findings demonstrate a critical role of caspase-1 in macrophage-driven inflammation in the adipose tissue and the development of obesity.
Inflammasome NLRP3 (show NLRP3 Proteins)-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.
Src kinase (show CSK Proteins) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets
endometrial expression of CASP1 and IL18 (show IL18 Proteins) associated with pregnancy establishment; alteration of CASP1 and IL18 (show IL18 Proteins) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
drICE (show CASP3 Proteins) and dcp-1 (show ACE Proteins) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (show CASP3 Proteins) but not dcp-1 (show ACE Proteins), but required drICE (show CASP3 Proteins) and dcp-1 (show ACE Proteins) when drICE (show CASP3 Proteins) activity was reduced via hypomorphic mutation.
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Proteins), and ice
Autophagy suppresses Dcp-1 (show ACE Proteins)-mediated apoptotic cell death, whereas Dcp-1 (show ACE Proteins) positively regulates autophagy, possibly through feedback regulation.
novel characteristic morphological features of egg chambers lacking both dcp-1 (show ACE Proteins) and pita functions in the germline cells; suggested an essential role of dcp-1 (show ACE Proteins) and/or pita during mid-oogenesis
A double-mutant analysis between drICE (show CASP3 Proteins) and death caspase-1 (dcp-1), another effector caspase (show CASP3 Proteins), reveals that some cells (type I) strictly require drICE (show CASP3 Proteins) for apoptosis, whereas other cells (type II) require either drICE (show CASP3 Proteins) or dcp-1 (show ACE Proteins).
Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death in Drosophila.
HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (show ACE Proteins), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
Bombyx mori caspase-1 plays an important role during baculovirus infection.
cBm-IAP1 (show BIRC3 Proteins) is a vital negative regulator of apoptosis in BM-N cells and functions by preventing the activation and/or activity of Bm-Dronc and Bm-caspase-1.
Activation of Atg5 (show ATG5 Proteins), AIF (show AIFM1 Proteins) and caspase (show CASP3 Proteins) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
CASP1 nirs variant 1
, IL-1 beta-converting enzyme
, caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
, interleukin 1, beta, convertase
, interleukin 1-B converting enzyme
, IL-1B converting enzyme
, interleukin 1 beta-converting enzyme
, interleukin-1 beta convertase
, interleukin-1 beta-converting enzyme
, Interleukin 1beta converting enzyme
, caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
, interleukin-1 beta converting enzyme
, caspase-1/caspase-4 hybrid
, caspase 1
, death caspase-1