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Human Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2487270
Chen, Xia, Fang, Hawke, Lu: Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. in Molecular and cellular biology 2009
Show all 8 Pubmed References
Mouse (Murine) Caspase 1 Protein expressed in Escherichia coli (E. coli) - ABIN2487280
Newman, Leppla, Moayeri: CA-074Me protection against anthrax lethal toxin. in Infection and immunity 2009
Show all 4 Pubmed References
The increased expression of NLRP3 (show NLRP3 Proteins) and caspase-1 in fetal membrane and placental tissues may be associated with the development of premature rupture of membrane.
inflammasome activation and pyroptosis in human microglia and ODCs in vitro after exposure to inflammatory stimuli and demonstrate caspase-1 inhibition by the small-molecule inhibitor VX-765 in both cell types. GSDMD (show GSDMD Proteins) inhibition by siRNA transduction suppressed pyroptosis in human microglia.
Increased production of caspase-1 in the gut (show GUSB Proteins)-associated lymphoid tissue and peripheral blood of HIV infected patients.
Low CASP1 expression is associated with prostate cancer.
These findings confirm the involvement of caspase-1 in non-classical secretion mechanisms and open novel perspectives for the extracellular function of secreted GBP-1 (show GBP1 Proteins).
this study demonstrates that the G+7/in6A and A10370-G polymorphisms of the CASP1 gene are associated with increased risk of developing acute coronary syndrome in Mexican population
After genotype calling and quality control filtering with exclusion of 3 cases and 3 controls, association analysis was performed across 76 directly genotyped SNPs in NLRP1, CARD, and CASP1 genes, adjusting for age, sex, and population stratification
Caspase-1 role in pyroptosis in glioma cells.Mir-214 regulates caspase-1 expression in glioma.
Data show that cyclic stretch activated the nucleotide-binding oligomerization domain-like receptor containing pyrin (show MEFV Proteins) domain 1 and 3 (NLRP1 and NLRP3 (show NLRP3 Proteins)) inflammasomes and induced the release of IL-1beta (show IL1B Proteins) and pyroptosis via a caspase-1-related mechanism in human periodontal ligament cells (HPDLCs).
Caspase-1 directly cleaves alpha-Synuclein, generating a highly aggregation-prone species in neurons.
The enzymatic activities of caspase-1 and caspase-11 (show CASP4 Proteins) are required for growth inhibition in different cell types.These results reveal that these proteases have important functions beyond the direct induction of pyroptosis and proinflammatory cytokine secretion in the control of growth and elimination of cytosolic bacteria.
Collectively, these results are consistent with a model whereby the type III secretion system apparatus of Pseudomonas aeruginosa activates the caspase-1-dependent inflammasome and caspase-3 (show CASP3 Proteins)/7 through an ASC (show STS Proteins)-dependent mechanism.
The results of this study indicated that beta-Amyloid peptide (show APP Proteins)-induced caspase-1 activation, disrupts autophagy in the cortex and in the hippocampus resulting in neurodegeneration and memory loss.
caspase-1 regulates dopaminergic neuronal death in the pathogenesis of Parkinson's disease in mice via caspase-7 (show CASP7 Proteins)/PARP1 (show PARP1 Proteins)/AIF (show AIFM1 Proteins) pathway.
RIP3-mediated activation of caspase-1 rather than necroptosis-dependent inflammation was responsible for aggressive inflammation in influenza A (H7N9) virus-infected mice.
we assessed the role of RIP3 in synergy with Caspase-1 in the induction of IL-1beta (show IL1B Proteins) production in BMDM after either LPS (show TLR4 Proteins)/ATP or Chlamydia muridarum stimulation. The possibility of pyroptosis and necroptosis interplays and the role of RIP3 in IL-1beta (show IL1B Proteins) production during Chlamydia muridarum infection in BMDM was investigated as well.
Studied the role of transient receptor potential melastatin 2 (show TRPM3 Proteins) (TRPM2 (show TRPM2 Proteins)) in activating caspase-1 and caspase-1-dependent pyroptosis in mouse BMDMs. Found TRPM2 (show TRPM2 Proteins) knockout caused higher caspase-1 activation and pyrotopsis.
The results demonstrate the activation of the caspase 1 precursor by caspase 11 (show CASP4 Proteins) and suggest a new mechanism of protection of Theiler murine encephalomyelitis virus-infected astrocytes from apoptosis.
Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines and caspase-1 activation
Adult neural stem cells (ANSCs) expressed NLRP3 (show NLRP3 Proteins)-containing inflammasome and alpha-syn activated both TLR4 (show TLR4 Proteins)/NF-kappaB (show NFKB1 Proteins) and NLRP3 (show NLRP3 Proteins)/caspase-1 signals in ANSCs.
Src kinase (show CSK Proteins) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets
endometrial expression of CASP1 and IL18 (show IL18 Proteins) associated with pregnancy establishment; alteration of CASP1 and IL18 (show IL18 Proteins) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
drICE (show CASP3 Proteins) and dcp-1 (show ACE Proteins) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (show CASP3 Proteins) but not dcp-1 (show ACE Proteins), but required drICE (show CASP3 Proteins) and dcp-1 (show ACE Proteins) when drICE (show CASP3 Proteins) activity was reduced via hypomorphic mutation.
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Proteins), and ice
Autophagy suppresses Dcp-1 (show ACE Proteins)-mediated apoptotic cell death, whereas Dcp-1 (show ACE Proteins) positively regulates autophagy, possibly through feedback regulation.
novel characteristic morphological features of egg chambers lacking both dcp-1 (show ACE Proteins) and pita functions in the germline cells; suggested an essential role of dcp-1 (show ACE Proteins) and/or pita during mid-oogenesis
A double-mutant analysis between drICE (show CASP3 Proteins) and death caspase-1 (dcp-1), another effector caspase (show CASP3 Proteins), reveals that some cells (type I) strictly require drICE (show CASP3 Proteins) for apoptosis, whereas other cells (type II) require either drICE (show CASP3 Proteins) or dcp-1 (show ACE Proteins).
Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death in Drosophila.
HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (show ACE Proteins), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
Bombyx mori caspase-1 plays an important role during baculovirus infection.
cBm-IAP1 (show BIRC3 Proteins) is a vital negative regulator of apoptosis in BM-N cells and functions by preventing the activation and/or activity of Bm-Dronc and Bm-caspase-1.
Activation of Atg5 (show ATG5 Proteins), AIF (show AIFM1 Proteins) and caspase (show CASP3 Proteins) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
CASP1 nirs variant 1
, IL-1 beta-converting enzyme
, caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
, interleukin 1, beta, convertase
, interleukin 1-B converting enzyme
, IL-1B converting enzyme
, interleukin 1 beta-converting enzyme
, interleukin-1 beta convertase
, interleukin-1 beta-converting enzyme
, Interleukin 1beta converting enzyme
, caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
, interleukin-1 beta converting enzyme
, caspase-1/caspase-4 hybrid
, caspase 1
, death caspase-1