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|Antigen||Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies|
|Epitope||AA 225-401 Alternatives|
|Conjugate||This Caspase 2 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-Caspase 2 AntibodyTarget Details Caspase 2 Application Details Handling References for anti-Caspase 2 antibody (ABIN968323) Images
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human ICH-1L aa. 225-401|
Target Details Caspase 2Product Details anti-Caspase 2 Antibody Application Details Handling References for anti-Caspase 2 antibody (ABIN968323) Images back to top
|Alternative Name||Caspase-2 (CASP2 Antibody Abstract)|
Caspase-2/ICH-1 is related to the C. elegans cell death gene product CED-3 and its mammalian homologue interleukin-1beta-converting enzyme (ICE). Caspase-2 /ICH-1 was identified from a mouse cDNA library and originally termed NEDD-2. The NEDD-2 mRNA was found to be expressed during early mouse embryonic brain development and subsequently down-regulated in adult neuronal tissue. With the identification of the human NEDD-2 gene, the murine gene was renamed Ich-1 to symbolize Ice and ced-3 homology. Caspase-2/ICH-1 mRNA is alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as Caspase-2 long, or ICH-1L. The smaller mRNA species encoding a protein of 312 amino acids is named Caspase-2 short, or ICH-1S. Overexpression of ICH-1L induces apoptosis, while over-expression of Ich-1S suppresses Rat-1 cell death induced by serum deprivation. Thus, it appears that Caspase-2/ICH-1 plays an important dual role in programmed cell death.
|Molecular Weight||48 kDa|
|Research Area||Apoptosis/Necrosis, Cancer, Autophagy|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Handling References for anti-Caspase 2 antibody (ABIN968323) Images back to top
Related Products: ABIN968537, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details References for anti-Caspase 2 antibody (ABIN968323) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20°C.|
References for anti-Caspase 2 antibody (ABIN968323)Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling Images back to top
|Product cited in:||
Guo, Srinivasula, Druilhe, Fernandes-Alnemri, Alnemri: "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13430-7, 2002
Li, Chen, Sinogeeva, Gorospe, Wersto, Chrest, Barnes, Liu: "Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49504-10, 2002
Mancini, Machamer, Roy, Nicholson, Thornberry, Casciola-Rosen, Rosen: "Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis." in: The Journal of cell biology, Vol. 149, Issue 3, pp. 603-12, 2000
Shibata, Hisahara, Hara, Yamawaki, Fukuuchi, Yuan, Okano, Miura: "Caspases determine the vulnerability of oligodendrocytes in the ischemic brain." in: The Journal of clinical investigation, Vol. 106, Issue 5, pp. 643-53, 2000
Wang, Miura, Bergeron, Zhu, Yuan: "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death." in: Cell, Vol. 78, Issue 5, pp. 739-50, 1994
ImagesProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling References for anti-Caspase 2 antibody (ABIN968323) back to top