anti-Human Caspase 2 antibody for Immunoprecipitation

Recommended Caspase 2 Antibody (supplied by: Log in to see )

Antigen
Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies
  • xCaspase-2
  • Caspase-2
  • ICH-1
  • Nedd2
  • CASP-2
  • ICH1
  • NEDD-2
  • NEDD2
  • PPP1R57
  • ICH-1L/1S
  • ICH1L1S
  • caspase 2
  • caspase 2 L homeolog
  • caspase-2
  • CASP2
  • casp2.L
  • CpipJ_CPIJ008254
  • Casp2
Reactivity
Dog (Canine), Human, Monkey, Mouse (Murine), Rat (Rattus)
211
92
69
11
9
2
2
2
2
2
1
1
1
1
1
1
Host
Rat
160
48
14
Clonality
Monoclonal
Conjugate
This Caspase 2 antibody is un-conjugated
6
6
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
184
102
49
36
19
15
14
13
10
4
4
4
2
1
Supplier
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Catalog No. ABIN5690633
$ 584.38
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1493071 IHC (p) IP WB Sepharose Rabbit C-Term Log in to see Polyclonal 0
1 ABIN1493070 IHC (p) IP WB Magnetic Particles Rabbit C-Term Log in to see Polyclonal 0
1 ABIN198455 IP WB Rat IgG2a Log in to see 0
1 ABIN333790 IHC (p) IP WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN2617930 IP WB Rat IgG2a, kappa Log in to see 11B4 0
1 ABIN5564278 ELISA FACS ICC IHC IP WB Rat IgG2a Subunit p19 Log in to see 11B4 0
1 ABIN2218998 IP WB Rat IgG2a Log in to see 6D217 0
1 ABIN187544 IP WB Rat IgG2a Log in to see 11B4 0
1 ABIN1690459 IP Sepharose Rabbit Log in to see Polyclonal 0
1 ABIN1690111 IP Magnetic Particles Rabbit Log in to see Polyclonal 0

General

Antigen Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies
Reactivity Dog (Canine), Human, Monkey, Mouse (Murine), Rat (Rattus)
(211), (92), (69), (11), (9), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Host Rat
(160), (48), (14)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Caspase 2 antibody is un-conjugated
(6), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(184), (102), (49), (36), (19), (15), (14), (13), (10), (4), (4), (4), (2), (1)
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Product Details anti-Caspase 2 Antibody

Target Details Caspase 2 Application Details Handling Images
Specificity Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. Detects bands of ~51  kDa (procaspase-2), ~32  kDa and ~18  kDa (cleavage products) by Western blot.
Purity > 95% (SDS-PAGE)
Immunogen Recombinant human caspase-2 (p19 subunit).
Clone 11B4
Isotype IgG2a, kappa

Target Details Caspase 2

Product Details anti-Caspase 2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Caspase-2 (CASP2 Antibody Abstract)
Background Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.
Gene ID 835
UniProt P42575
Pathways Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway

Application Details

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Handling Images back to top
Application Notes Immunoprecipitation: (1-5 μg/mL) . Western Blot: (1-2 μg/mL) . Optimal conditions must be determined individually for each application.
Restrictions For Research Use only

Handling

Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Liquid. In PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Stable for at least 1 year after receipt when stored at -20°C.