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|Antigen||Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) Antibodies|
|Epitope||AA 417-439, C-Term Alternatives|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This Caspase 2 antibody is un-conjugated Alternatives|
Western Blotting (WB)
|27 references available|
|Supplier||Log in to see|
Product Details anti-Caspase 2 AntibodyTarget Details Caspase 2 Application Details Handling References for anti-Caspase 2 antibody (ABIN3043696) Images
|Purpose||Rabbit IgG polyclonal antibody for Caspase-2(CASP2) detection. Tested with WB in Human,Mouse,Rat.|
|Sequence||REGYAPGTEF HRCKEMSEYC STL|
Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
Rabbit IgG polyclonal antibody for Caspase-2(CASP2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: caspase 2, apoptosis-related cysteine peptidase
Protein Name: Caspase-2(CASP-2)
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human Caspase-2(417-439aa REGYAPGTEFHRCKEMSEYCSTL), identical to the related rat and mouse sequences.|
|Plasmids, Primers & others|
Target Details Caspase 2Product Details anti-Caspase 2 Antibody Application Details Handling References for anti-Caspase 2 antibody (ABIN3043696) Images back to top
|Alternative Name||CASP2 (CASP2 Antibody Abstract)|
Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.
Synonyms: Apoptosis related cysteine peptidase antibody|CASP 2 antibody|Casp 2L Pro antibody|CASP-2 antibody|CASP2 antibody|CASP2_HUMAN antibody|Caspase 2 apoptosis related cysteine protease antibody|Caspase-2 subunit p12 antibody|Caspase2 antibody|Developmentally down regulated 2 antibody|ICH 1 antibody|ICH 1 protease antibody|ICH 1L antibody|ICH 1L/1S antibody|ICH1 antibody|ICH1 protease antibody|ICH1L antibody|ICH1L/1S antibody|NEDD 2 antibody|NEDD-2 antibody|NEDD2 antibody|NEDD2 apoptosis regulatory gene antibody|Neural precursor cell expressed antibody|Neural precursor cell expressed developmentally down regulated 2 antibody|Neural precursor cell expressed developmentally down-regulated protein 2 antibody|Protease ICH-1 antibody
|Pathways||Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Handling References for anti-Caspase 2 antibody (ABIN3043696) Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details References for anti-Caspase 2 antibody (ABIN3043696) Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|Preservative||Thimerosal (Merthiolate), Sodium azide|
|Precaution of Use||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
References for anti-Caspase 2 antibody (ABIN3043696)Product Details anti-Caspase 2 Antibody Target Details Caspase 2 Application Details Handling Images back to top
|Product cited in:||
Kan, Zhou, Jin, Yang: "Effects of PDTC on NF-?B expression and apoptosis in rats with severe acute pancreatitis-associated lung injury." in: International journal of clinical and experimental medicine, Vol. 8, Issue 3, pp. 3258-70, 2015
Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: "Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy." in: Neural regeneration research, Vol. 7, Issue 17, pp. 1318-24, 2015
Ding, Wang, Zhao, Sun, Zhai: "Protective Effects of Baicalin on A?????-Induced Learning and Memory Deficit, Oxidative Stress, and Apoptosis in Rat." in: Cellular and molecular neurobiology, Vol. 35, Issue 5, pp. 623-32, 2015
Yang, Li, Liu, Shi, Zhang: "Inhibitory effect of tetramethylpyrazine preconditioning on overload training-induced myocardial apoptosis in rats." in: Chinese journal of integrative medicine, Vol. 21, Issue 6, pp. 423-30, 2015
Li, Wang, Wang: "Radioprotective activity of neutral polysaccharides isolated from the fruiting bodies of Hohenbuehelia serotina." in: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), Vol. 31, Issue 4, pp. 352-9, 2015
Zhan, Hu, Yi, An, Huang: "Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo." in: Molecular medicine reports, Vol. 11, Issue 6, pp. 4142-8, 2015
Peng, Chen, Chen, Fang, Cui, Zuo, Deng, Chen, Geng, Lai: "Aflatoxin B1 affects apoptosis and expression of Bax, Bcl-2, and Caspase-3 in thymus and bursa of fabricius in broiler chickens." in: Environmental toxicology, 2015
Huang, Lin, Su, Ye: "Forsythiaside protects against hydrogen peroxide-induced oxidative stress and apoptosis in PC12 cell." in: Neurochemical research, Vol. 40, Issue 1, pp. 27-35, 2015
Jiang, Li, Zhou, Wang, Zhang, Wang: "Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways." in: International journal of molecular medicine, Vol. 33, Issue 5, pp. 1298-304, 2014
Yan, Liang, Zhang, Liu, Bu: "Apoptotic induction of lung adenocarcinoma A549 cells infected by recombinant RVG Newcastle disease virus (rL-RVG) in vitro." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 317-26, 2014
Wei, Tian, Yan, Shao, Xie: "Protective effects of phillyrin on H2O 2-induced oxidative stress and apoptosis in PC12 cells." in: Cellular and molecular neurobiology, Vol. 34, Issue 8, pp. 1165-73, 2014
Mao, Song, Li, Lv, Zhao, Li, Feng, Chen: "8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury." in: Neural regeneration research, Vol. 8, Issue 2, pp. 133-42, 2014
Tian, Wei, Li, Wang, Zhang, Xie: "Pathway of programmed cell death and oxidative stress induced by ?-hydroxybutyrate in dairy cow abomasum smooth muscle cells and in mouse gastric smooth muscle." in: PLoS ONE, Vol. 9, Issue 5, pp. e96775, 2014
Song, Wang, Chen, Zhang, Wang, Liu, Gao, Yan: "Toxic effects of sodium fluoride on cell proliferation and apoptosis of Leydig cells from young mice." in: Journal of physiology and biochemistry, Vol. 70, Issue 3, pp. 761-8, 2014
Dong, Wang: "Antitumor effects of artesunate on human breast carcinoma MCF-7 cells and IGF-IR expression in nude mice xenografts." in: Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, Vol. 26, Issue 2, pp. 200-7, 2014
Zhao, Li: "Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression." in: Oncology reports, Vol. 31, Issue 6, pp. 2769-75, 2014
Khan, Li, Ahmad Khan, Rasul, Nawaz, Sun, Zheng, Ma: "Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction." in: BioMed research international, Vol. 2013, pp. 719858, 2013
Chen, Shu, Peng, Fang, Cui, Chen, Wang, Chen, Zuo, Deng, Geng, Lai: "Protective role of sodium selenite on histopathological lesions, decreased T-cell subsets and increased apoptosis of thymus in broilers intoxicated with aflatoxin B?." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 59, pp. 446-54, 2013
Chen, Li, Qiu, You, Zhang, Dong, Zuo: "Kinetics of apoptosis and expression of apoptosis-related proteins in rat CA3 hippocampus cells after experimental diffuse brain injury." in: Cell biochemistry and biophysics, Vol. 67, Issue 3, pp. 1015-9, 2013
Rasul, Yu, Khan, Zhang, Iqbal, Ma, Yang: "Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways." in: International journal of oncology, Vol. 40, Issue 4, pp. 1153-61, 2012
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