anti-Human Caspase 4 antibody for Immunohistochemistry

Recommended Caspase 4 Antibody (supplied by: Log in to see )

Antigen
Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies
  • ICE(rel)II
  • ICEREL-II
  • ICH-2
  • Mih1/TX
  • TX
  • Casp11
  • CASP13
  • CASP1
  • CASP4
  • Caspl
  • ich-3
  • Casp4
  • caspase 4
  • caspase 4, apoptosis-related cysteine peptidase
  • caspase-4
  • CASP4
  • Casp4
  • LOC100731032
Reactivity
Human, Mouse (Murine)
208
104
44
21
3
1
1
Host
Rat
206
27
18
18
7
Clonality
Monoclonal
Conjugate
This Caspase 4 antibody is un-conjugated
18
15
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Microarray (MA), Western Blotting (WB)
264
100
98
54
30
24
18
17
17
10
3
2
2
1
1
Options
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Available images

Catalog No. ABIN265762
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
15.987052 ABIN1858247 ICC IHC WB Rabbit IgG AA 290-377 Log in to see Polyclonal 0
13 ABIN2899476 IF/ICC IHC IP WB Rabbit AA 290-377 Log in to see Polyclonal 0
12.987052 ABIN6260482 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
12.987052 ABIN462477 IHC IHC (p) WB Rabbit IgG Internal Region Log in to see Polyclonal 0
12.987052 ABIN214595 IHC IHC (p) WB Rabbit Log in to see Polyclonal 0
12.987052 ABIN5693193 ELISA IHC WB Rabbit AA 111-194 Log in to see Polyclonal 0
12.987052 ABIN5013301 ICC IHC WB Rabbit IgG AA 944-1148 Log in to see Polyclonal 0
12.026281 ABIN3183668 ELISA IHC WB Rabbit IgG Internal Region Log in to see Polyclonal 0
12.026281 ABIN5619063 IHC WB Rabbit Center Log in to see Polyclonal 0
12.026281 ABIN2135424 IHC ELISA WB Rabbit IgG Log in to see Polyclonal 0
10 ABIN6260486 ELISA ICC IF IHC WB Rabbit IgG Log in to see Polyclonal 0
10 ABIN2902455 IF/ICC IHC IP WB Rabbit AA 944-1148 Log in to see Polyclonal 0
9.987052 ABIN2705686 IHC WB Rabbit Center Log in to see Polyclonal 0
9.987052 ABIN462473 IHC IHC (p) WB Rabbit IgG N-Term Log in to see Polyclonal 0
9.987052 ABIN298192 IHC IHC (p) WB Chicken IgY AA 1-89 Log in to see Polyclonal 0
9.987052 ABIN1031297 IHC ELISA WB Rabbit N-Term Log in to see Polyclonal 0
9.987052 ABIN1030900 IHC ELISA WB Rabbit Middle Region Log in to see Polyclonal 0
9.987052 ABIN6656989 ELISA IHC WB Rabbit IgG N-Term Log in to see Polyclonal 0
9.987052 ABIN920894 IHC WB Rabbit Log in to see Polyclonal 0
9.987052 ABIN1031750 IHC ELISA WB Rabbit Log in to see Polyclonal 0

General

Antigen Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies
Reactivity Human, Mouse (Murine)
(208), (104), (44), (21), (3), (1), (1)
Host Rat
(206), (27), (18), (18), (7)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Caspase 4 antibody is un-conjugated
(18), (15), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Microarray (MA), Western Blotting (WB)
(264), (100), (98), (54), (30), (24), (18), (17), (17), (10), (3), (2), (2), (1), (1)
Pubmed 29 references available
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Product Details anti-Caspase 4 Antibody

Target Details Caspase 4 Application Details Handling References for anti-Caspase 4 antibody (ABIN265762) Images
Purification Protein G purified
Immunogen A recombinant p30 subunit of mouse Caspase 11. [UniProt# P70343]
Clone 17D9
Isotype IgG2a
Plasmids, Primers & others

Target Details Caspase 4

Product Details anti-Caspase 4 Antibody Application Details Handling References for anti-Caspase 4 antibody (ABIN265762) Images back to top
Antigen
Alternative Name Caspase-11 (CASP4 Antibody Abstract)
Background Gene Symbol: CASP11
Molecular Weight Theoretical MW: 35-43 kDa
Gene ID 12363
UniProt P70343
Pathways Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Handling References for anti-Caspase 4 antibody (ABIN265762) Images back to top
Application Notes Western Blot 5 μg/mL, ELISA, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:100, Immunoprecipitation, Immunohistochemistry-Paraffin 1:100, Immunohistochemistry-Frozen 1:10-1:500, MicroarrayUse in immunprecipitation reported in scientific literature (PMID 10791975) The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only

Handling

Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details References for anti-Caspase 4 antibody (ABIN265762) Images back to top
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS
Buffer contains: 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

References for anti-Caspase 4 antibody (ABIN265762)

Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Handling Images back to top
Product cited in:

Quach, Moreau, Sandall, Chadee: "Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D." in: Mucosal immunology, Vol. 12, Issue 2, pp. 323-339, 2019 Method employed by authors: Immunoprecipitation (IP) (Sample species: Human).

Kolb, Phan, Borcherding, Liu, Yuan, Janowski, Xie, Markan, Li, Potthoff, Fuentes-Mattei, Ellies, Knudson, Lee, Yeung, Cassel, Sutterwala, Zhang: "Obesity-associated NLRC4 inflammasome activation drives breast cancer progression." in: Nature communications, Vol. 7, pp. 13007, 2018

Deigendesch, Zychlinsky, Meissner: "Copper Regulates the Canonical NLRP3 Inflammasome." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 5, pp. 1607-1617, 2018

Balakrishnan, Karki, Berwin, Yamamoto, Kanneganti: "Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa." in: Cell death discovery, Vol. 5, pp. 3, 2018

Man, Karki, Briard, Burton, Gingras, Pelletier, Kanneganti: "Differential roles of caspase-1 and caspase-11 in infection and inflammation." in: Scientific reports, Vol. 7, pp. 45126, 2017 (Sample species: Mouse (Murine)).

Jin, Oda, Chen, Yang, Zhou, Kang, Valentine, Kefauver, Liao, Zhang, Gonzalez-Martin, Shepherd, Morgan, Mondala, Head, Kim, Xiao, Fu, Liu, Han, Williamson, Xiao: "Differential Sensitivity of Target Genes to Translational Repression by miR-17~92." in: PLoS genetics, Vol. 13, Issue 2, pp. e1006623, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).

Cheng, Xiong, Ye, Hong, Di, Tsang, Gao, An, Mittal, Vogel, Miao, Rehman, Malik: "Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury." in: The Journal of clinical investigation, Vol. 127, Issue 11, pp. 4124-4135, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).

Kerur, Fukuda, Banerjee, Kim, Fu, Apicella, Varshney, Yasuma, Fowler, Baghdasaryan, Marion, Huang, Yasuma, Hirano, Serbulea, Ambati, Ambati, Kajiwara, Ambati, Hirahara, Bastos-Carvalho, Ogura et al.: "cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. ..." in: Nature medicine, Vol. 24, Issue 1, pp. 50-61, 2017 (Sample species: Human).

Man, Karki, Sasai, Place, Kesavardhana, Temirov, Frase, Zhu, Malireddi, Kuriakose, Peters, Neale, Brown, Yamamoto, Kanneganti: "IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes." in: Cell, Vol. 167, Issue 2, pp. 382-396.e17, 2017

Chung, Vilaysane, Lau, Stahl, Morampudi, Bondzi-Simpson, Platnich, Bracey, French, Beck, Chun, Vallance, Muruve: "NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis." in: Cell death and differentiation, Vol. 23, Issue 8, pp. 1331-46, 2016 (Sample species: Mouse (Murine)). Further details: Western Blotting

Kim, Bae, Ryu, Kwon, Oh, Kwon, Moon, Kim, Miyawaki, Lee, Shin, Kim, Kim, Ryter, Choi, Rhee, Ryu, Yoon: "SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages." in: Autophagy, Vol. 12, Issue 8, pp. 1272-91, 2016 Further details: Western Blotting,Immunoprecipitation

Klaska, Muckersie, Martin-Granados, Christofi, Forrester: "Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms." in: Immunology, Vol. 150, Issue 3, pp. 364-377, 2016

Youm, Nguyen, Grant, Goldberg, Bodogai, Kim, DAgostino, Planavsky, Lupfer, Kanneganti, Kang, Horvath, Fahmy, Crawford, Biragyn, Alnemri, Dixit: "The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease." in: Nature medicine, Vol. 21, Issue 3, pp. 263-9, 2015 (Sample species: Human). Further details: Western Blotting

Aachoui, Kajiwara, Leaf, Mao, Ting, Coers, Aderem, Buxbaum, Miao: "Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium." in: Cell host & microbe, Vol. 18, Issue 3, pp. 320-32, 2015 (Sample species: Mouse (Murine)). Further details: Western Blotting

Shi, Zhao, Wang, Shi, Wang, Huang, Zhuang, Cai, Wang, Shao: "Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death." in: Nature, Vol. 526, Issue 7575, pp. 660-5, 2015 (Sample species: Mouse (Murine)). Further details: Western Blotting

Kayagaki, Stowe, Lee, ORourke, Anderson, Warming, Cuellar, Haley, Roose-Girma, Phung, Liu, Lill, Li, Wu, Kummerfeld, Zhang, Lee, Snipas, Salvesen, Morris, Fitzgerald, Zhang, Bertram, Goodnow, Dixit: "Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling." in: Nature, Vol. 526, Issue 7575, pp. 666-71, 2015 (Sample species: Mouse (Murine)). Further details: Western Blotting

Diabate, Munro, Garcia, Jacquel, Michel, Obba, Goncalves, Luci, Marchetti, Demon, Degos, Bechah, Mege, Lamkanfi, Auberger, Gorvel, Stuart, Landraud, Lemichez, Boyer: "Escherichia coli ?-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004732, 2015 (Sample species: Mouse (Murine)). Further details: ELISA

Bonora, Wieckowsk, Chinopoulos, Kepp, Kroemer, Galluzzi, Pinton: "Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition." in: Oncogene, Vol. 34, Issue 12, pp. 1608, 2015

Demon, Kuchmiy, Fossoul, Zhu, Kanneganti, Lamkanfi: "Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis." in: Mucosal immunology, Vol. 7, Issue 6, pp. 1480-91, 2015

Yuan, Syed, Panchal, Joo, Colonna, Brantly, Sadikot: "Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival." in: The Journal of biological chemistry, Vol. 289, Issue 21, pp. 15118-29, 2014 (Sample species: Mouse (Murine)). Further details: Western Blotting

Images

Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Handling References for anti-Caspase 4 antibody (ABIN265762) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Immunohistochemistry-Paraffin: Caspase 11 Antibody (17D9) [ABIN2657624] - IHC-P analy...
Western Blotting (WB) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Western Blot: Caspase 11 Antibody (17D9) [ABIN2657624] - Mouse B cell. Image from ver...
Immunofluorescence (IF) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Immunocytochemistry/Immunofluorescence: Caspase 11 Antibody (17D9) [ABIN2657624] - Ca...
Western Blotting (WB) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Western Blot: Caspase 11 Antibody (17D9) [ABIN2657624] - Mouse liver extract was sepa...
Western Blotting (WB) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Western Blot: Caspase 11 Antibody (17D9) [ABIN2657624] - analysis of Caspase 11 in LP...
Western Blotting (WB) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Western Blot: Caspase-11 Antibody (17D9) [ABIN2657624] - Analysis of Caspase-11 in TH...
Western Blotting (WB) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Western Blot: Caspase-11 Antibody (17D9) - Casp11fl/fl and Casp11EC-/- mice (n = 3) ...