anti-Mouse (Murine) Caspase 4 antibody for ELISA

Recommended Caspase 4 Antibody (supplied by: Log in to see )

Antigen
Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies
  • ICE(rel)II
  • ICEREL-II
  • ICH-2
  • Mih1/TX
  • TX
  • Casp11
  • CASP13
  • CASP1
  • CASP4
  • Caspl
  • ich-3
  • Casp4
  • caspase 4
  • caspase 4, apoptosis-related cysteine peptidase
  • caspase-4
  • CASP4
  • Casp4
  • LOC100731032
Reactivity
Human, Mouse (Murine)
197
111
51
21
3
1
1
Host
Rat
207
27
21
17
7
Clonality
Monoclonal
Conjugate
This Caspase 4 antibody is un-conjugated
19
16
5
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Microarray (MA), Western Blotting (WB)
256
92
91
57
30
24
18
17
17
13
10
3
2
1
1
Supplier
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Catalog No. ABIN265762
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2745522 FACS IP ELISA WB Rat IgG1 Log in to see 8A5 0
1 ABIN2745523 FACS IP ELISA WB Rat IgG1 Log in to see 4-00E-11 0
1 ABIN3183668 ELISA IHC WB Rabbit IgG Internal Region Log in to see Polyclonal 0
1 ABIN5693194 ELISA WB Rabbit AA 108-195 Log in to see Polyclonal 0
1 ABIN1453020 IHC ELISA WB Rabbit IgG AA 75-124 Log in to see Polyclonal 0
1 ABIN6260486 ELISA ICC IF IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN6260482 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN1031297 IHC ELISA WB Rabbit N-Term Log in to see Polyclonal 0
1 ABIN4288032 ELISA ICC IF IHC IHC (fro) IHC (p) IP MA WB Rat IgG2a Log in to see 17D9 0
1 ABIN2745521 ELISA WB Mouse IgG2b AA 81-373 Log in to see Flamy-2 0
1 ABIN958378 ELISA WB Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN2219126 IC IHC ELISA WB Rabbit IgG AA 81-266 Log in to see Polyclonal 0
1 ABIN4288126 ELISA ICC IF IHC IHC (p) WB Rabbit N-Term Log in to see Polyclonal 0
1 ABIN4288036 ELISA ICC IF IHC (fro) IHC (p) WB Alexa Fluor 647 Rat IgG2a Log in to see 17D9 0
1 ABIN4288034 ELISA ICC IF IHC (fro) IHC (p) WB Alexa Fluor 405 Rat IgG2a Log in to see 17D9 0
1 ABIN4288035 ELISA ICC IF IHC (fro) IHC (p) WB Alexa Fluor 488 Rat IgG2a Log in to see 17D9 0
1 ABIN4288037 ELISA ICC IF IHC (fro) IHC (p) WB Alexa Fluor 700 Rat IgG2a Log in to see 17D9 0
1 ABIN4288044 ELISA ICC IF IHC (fro) IHC (p) WB DyLight 550 Rat IgG2a Log in to see 17D9 0
1 ABIN4288041 ELISA ICC IF IHC (fro) IHC (p) WB DyLight 405 Rat IgG2a Log in to see 17D9 0
1 ABIN4288043 ELISA ICC IF IHC (fro) IHC (p) WB DyLight 488 Rat IgG2a Log in to see 17D9 0

General

Antigen Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies
Reactivity Human, Mouse (Murine)
(197), (111), (51), (21), (3), (1), (1)
Host Rat
(207), (27), (21), (17), (7)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Caspase 4 antibody is un-conjugated
(19), (16), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Microarray (MA), Western Blotting (WB)
(256), (92), (91), (57), (30), (24), (18), (17), (17), (13), (10), (3), (2), (1), (1)
Pubmed 28 references available
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Product Details anti-Caspase 4 Antibody

Target Details Caspase 4 Application Details Handling References for anti-Caspase 4 antibody (ABIN265762) Images
Purification Protein G purified
Immunogen A recombinant p30 subunit of mouse Caspase 11. [UniProt# P70343]
Clone 17D9
Isotype IgG2a
Plasmids, Primers & others

Target Details Caspase 4

Product Details anti-Caspase 4 Antibody Application Details Handling References for anti-Caspase 4 antibody (ABIN265762) Images back to top
Antigen
Alternative Name Caspase-11 (CASP4 Antibody Abstract)
Background Gene Symbol: CASP11
Molecular Weight Theoretical MW: 35-43 kDa
Gene ID 12363
UniProt P70343
Pathways Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Handling References for anti-Caspase 4 antibody (ABIN265762) Images back to top
Application Notes Western Blot 5 μg/mL, ELISA, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:100, Immunoprecipitation, Immunohistochemistry-Paraffin 1:100, Immunohistochemistry-Frozen 1:10-1:500, MicroarrayUse in immunprecipitation reported in scientific literature (PMID 10791975) The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only

Handling

Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details References for anti-Caspase 4 antibody (ABIN265762) Images back to top
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS
Buffer contains: 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

References for anti-Caspase 4 antibody (ABIN265762)

Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Handling Images back to top
Product cited in:

Kolb, Phan, Borcherding, Liu, Yuan, Janowski, Xie, Markan, Li, Potthoff, Fuentes-Mattei, Ellies, Knudson, Lee, Yeung, Cassel, Sutterwala, Zhang: "Obesity-associated NLRC4 inflammasome activation drives breast cancer progression." in: Nature communications, Vol. 7, pp. 13007, 2018

Deigendesch, Zychlinsky, Meissner: "Copper Regulates the Canonical NLRP3 Inflammasome." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 5, pp. 1607-1617, 2018

Balakrishnan, Karki, Berwin, Yamamoto, Kanneganti: "Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa." in: Cell death discovery, Vol. 5, pp. 3, 2018

Man, Karki, Briard, Burton, Gingras, Pelletier, Kanneganti: "Differential roles of caspase-1 and caspase-11 in infection and inflammation." in: Scientific reports, Vol. 7, pp. 45126, 2017 (Sample species: Mouse (Murine)).

Jin, Oda, Chen, Yang, Zhou, Kang, Valentine, Kefauver, Liao, Zhang, Gonzalez-Martin, Shepherd, Morgan, Mondala, Head, Kim, Xiao, Fu, Liu, Han, Williamson, Xiao: "Differential Sensitivity of Target Genes to Translational Repression by miR-17~92." in: PLoS genetics, Vol. 13, Issue 2, pp. e1006623, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).

Cheng, Xiong, Ye, Hong, Di, Tsang, Gao, An, Mittal, Vogel, Miao, Rehman, Malik: "Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury." in: The Journal of clinical investigation, Vol. 127, Issue 11, pp. 4124-4135, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).

Kerur, Fukuda, Banerjee, Kim, Fu, Apicella, Varshney, Yasuma, Fowler, Baghdasaryan, Marion, Huang, Yasuma, Hirano, Serbulea, Ambati, Ambati, Kajiwara, Ambati, Hirahara, Bastos-Carvalho, Ogura et al.: "cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. ..." in: Nature medicine, Vol. 24, Issue 1, pp. 50-61, 2017 (Sample species: Human).

Man, Karki, Sasai, Place, Kesavardhana, Temirov, Frase, Zhu, Malireddi, Kuriakose, Peters, Neale, Brown, Yamamoto, Kanneganti: "IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes." in: Cell, Vol. 167, Issue 2, pp. 382-396.e17, 2017

Chung, Vilaysane, Lau, Stahl, Morampudi, Bondzi-Simpson, Platnich, Bracey, French, Beck, Chun, Vallance, Muruve: "NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis." in: Cell death and differentiation, Vol. 23, Issue 8, pp. 1331-46, 2016 (Sample species: Mouse (Murine)). Further details: Western Blotting

Kim, Bae, Ryu, Kwon, Oh, Kwon, Moon, Kim, Miyawaki, Lee, Shin, Kim, Kim, Ryter, Choi, Rhee, Ryu, Yoon: "SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages." in: Autophagy, Vol. 12, Issue 8, pp. 1272-91, 2016 Further details: Western Blotting,Immunoprecipitation

Klaska, Muckersie, Martin-Granados, Christofi, Forrester: "Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms." in: Immunology, Vol. 150, Issue 3, pp. 364-377, 2016

Youm, Nguyen, Grant, Goldberg, Bodogai, Kim, DAgostino, Planavsky, Lupfer, Kanneganti, Kang, Horvath, Fahmy, Crawford, Biragyn, Alnemri, Dixit: "The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease." in: Nature medicine, Vol. 21, Issue 3, pp. 263-9, 2015 (Sample species: Human). Further details: Western Blotting

Aachoui, Kajiwara, Leaf, Mao, Ting, Coers, Aderem, Buxbaum, Miao: "Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium." in: Cell host & microbe, Vol. 18, Issue 3, pp. 320-32, 2015 (Sample species: Mouse (Murine)). Further details: Western Blotting

Shi, Zhao, Wang, Shi, Wang, Huang, Zhuang, Cai, Wang, Shao: "Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death." in: Nature, Vol. 526, Issue 7575, pp. 660-5, 2015 (Sample species: Mouse (Murine)). Further details: Western Blotting

Kayagaki, Stowe, Lee, ORourke, Anderson, Warming, Cuellar, Haley, Roose-Girma, Phung, Liu, Lill, Li, Wu, Kummerfeld, Zhang, Lee, Snipas, Salvesen, Morris, Fitzgerald, Zhang, Bertram, Goodnow, Dixit: "Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling." in: Nature, Vol. 526, Issue 7575, pp. 666-71, 2015 (Sample species: Mouse (Murine)). Further details: Western Blotting

Diabate, Munro, Garcia, Jacquel, Michel, Obba, Goncalves, Luci, Marchetti, Demon, Degos, Bechah, Mege, Lamkanfi, Auberger, Gorvel, Stuart, Landraud, Lemichez, Boyer: "Escherichia coli ?-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004732, 2015 (Sample species: Mouse (Murine)). Further details: ELISA

Bonora, Wieckowsk, Chinopoulos, Kepp, Kroemer, Galluzzi, Pinton: "Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition." in: Oncogene, Vol. 34, Issue 12, pp. 1608, 2015

Demon, Kuchmiy, Fossoul, Zhu, Kanneganti, Lamkanfi: "Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis." in: Mucosal immunology, Vol. 7, Issue 6, pp. 1480-91, 2015

Yuan, Syed, Panchal, Joo, Colonna, Brantly, Sadikot: "Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival." in: The Journal of biological chemistry, Vol. 289, Issue 21, pp. 15118-29, 2014 (Sample species: Mouse (Murine)). Further details: Western Blotting

Gurung, Anand, Malireddi, Vande Walle, Van Opdenbosch, Dillon, Weinlich, Green, Lamkanfi, Kanneganti: "FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 4, pp. 1835-46, 2014 (Sample species: Mouse (Murine)). Further details: Western Blotting

Images

Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Handling References for anti-Caspase 4 antibody (ABIN265762) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Immunohistochemistry-Paraffin: Caspase 11 Antibody (17D9) [ABIN2657624] - IHC-P analy...
Western Blotting (WB) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Western Blot: Caspase 11 Antibody (17D9) [ABIN2657624] - Mouse B cell. Image from ver...
Immunofluorescence (IF) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Immunocytochemistry/Immunofluorescence: Caspase 11 Antibody (17D9) [ABIN2657624] - Ca...
Western Blotting (WB) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Western Blot: Caspase 11 Antibody (17D9) [ABIN2657624] - Mouse liver extract was sepa...
Western Blotting (WB) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Western Blot: Caspase 11 Antibody (17D9) [ABIN2657624] - analysis of Caspase 11 in LP...
Western Blotting (WB) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Western Blot: Caspase-11 Antibody (17D9) [ABIN2657624] - Analysis of Caspase-11 in TH...
Western Blotting (WB) image for anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibody (ABIN265762) Western Blot: Caspase-11 Antibody (17D9) - Casp11fl/fl and Casp11EC-/- mice (n = 3) ...