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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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1 | ABIN2745522 | FACS IP ELISA WB | Rat | IgG1 | Log in to see | 8A5 | 0 | |||
1 | ABIN1453020 | IHC ELISA WB | Rabbit | IgG | AA 75-124 | Log in to see | Polyclonal | 0 | ||
1 | ABIN3183668 | ELISA IHC WB | Rabbit | IgG | Internal Region | Log in to see | Polyclonal | 0 | ||
1 | ABIN5690634 | ELISA FACS IP WB | Rat | IgG1, kappa | Log in to see | 4E11 | 0 | |||
1 | ABIN5690635 | ELISA FACS IP WB | Rat | IgG1, kappa | Log in to see | 8A5 | 0 | |||
1 | ABIN2617982 | ELISA FACS IP WB | Rat | IgG1, kappa | Log in to see | 4E11 | 0 | |||
1 | ABIN2617983 | ELISA FACS IP WB | Rat | IgG1, kappa | Log in to see | 8A5 | 0 | |||
1 | ABIN5693194 | ELISA WB | Rabbit | AA 108-195 | Log in to see | Polyclonal | 0 | |||
1 | ABIN2885852 | IHC ELISA WB | Rabbit | IgG | AA 75-124 | Log in to see | Polyclonal | 0 |
General |
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Antigen | Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies |
Reactivity | Mouse (Murine), Rat (Rattus) Alternatives |
Host | Rat Alternatives |
Clonality (Clone) | |
Conjugate | This Caspase 4 antibody is un-conjugated Alternatives |
Application |
Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA, Western Blotting (WB)
Alternatives
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Supplier | Log in to see |
Product Details anti-Caspase 4 AntibodyTarget Details Caspase 4 Application Details Handling Images |
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Specificity | Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38 kDa and ~43 kDa by Western blot. |
Cross-Reactivity | Mouse (Murine), Rat (Rattus) |
Purity | >95 % (SDS-PAGE) |
Endotoxin Level | <0.1EU/μg purified protein (LAL test, Lonza). |
Immunogen | Recombinant mouse caspase-11 (p20 fragment). |
Clone | 4-00E-11 |
Isotype | IgG1 |
Target Details Caspase 4Product Details anti-Caspase 4 Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | Caspase-11 (CASP4 Antibody Abstract) |
Background | Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. |
UniProt | P70343 |
Pathways | Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity |
Application DetailsProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Handling Images back to top |
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Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
HandlingProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Images back to top |
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Format | Liquid |
Concentration | 1 mg/mL |
Buffer | In PBS containing 0.02 % sodium azide. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | 4 °C,-20 °C |
Storage Comment |
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C. |
Expiry Date | 12 months |
ImagesProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Handling back to top |
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Supplier Images |