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Human Caspase 7 Protein expressed in Escherichia coli (E. coli) - ABIN413137
Chen, Xia, Fang, Hawke, Lu: Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. in Molecular and cellular biology 2009
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caspase-1 (show CASP1 Proteins) activation is an upstream event of apoptotic caspase-7 induction in renal tubulointerstitial fibrosis
Cepharanthine treatment reduced mitochondrial membrane potential and upregulated the level of cleaved caspases, including caspase-9 (show CASP9 Proteins) and caspase-3 (show CASP3 Proteins)/7, in a dose-dependent fashion.
Caspase 7 has a nonapoptic function that participates in normal spermatogenesis, but also displays apoptotic function in spermatogenic dysfunction.
Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin.
The results reveal that executioner caspases can modulate heart's cellularity and maturation during development, contributing novel information about caspase (show CASP3 Proteins) biology and heart development.
Optic nerve crush activated caspase-7 in retinal ganglion cells followed by cell death. Knockout of caspase-7 partially and significantly protected against ON injury-induced RGC loss.
Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 (show CASP3 Proteins) and -7-dependent.
genetic loss of caspase-7 promotes solar-simulated light-induced skin carcinogenesis by blocking caspase-7-mediated cleavage of keratin-17 (show KRT17 Proteins).
Interleukin-1beta enhances FasL (show FASL Proteins)-induced caspase-3 (show CASP3 Proteins)/-7 activity without increasing apoptosis in primary mouse hepatocytes
In vitro, with application of specific inhibitors and siRNA, AND-induced apoptosis was proven through ROS (show ROS1 Proteins)-ERK (show EPHB2 Proteins)-P53 (show TP53 Proteins)-caspase 7-PARP (show PARP1 Proteins) signaling pathway
Everolimus also induced higher levels of caspase-3 (show CASP3 Proteins)/-7 activation in GR over GS cells, and everolimus-mediated mTOR (show FRAP1 Proteins) inhibition lead to G2 arrest in GR cells but G1 arrest in GS cells.
CASP8 (show CASP8 Proteins): rs1045494 (C > T), PIK3R1: rs3756668 (A > G) and CASP7: rs4353229 (T > C), were associated with longer overall survival in limited disease-small cell lung cancer patients after chemoradiotherapy
Results show that caspase-7 is phosphorylated by PAK2 (show PAK2 Proteins) at S239 which inhibits its activity by two divergent mechanisms prior to and following caspase (show CASP3 Proteins) activation: initial phosphorylation allosterically slows activation by upstream initiator caspases by impeding cleavage at the intersubunit linker and a second phosphorylation site directly blocks substrate binding.
Caspase-7 regions involved in the interaction with Hsp90 co-chaperone p23 (show PTGES3 Proteins) and substrate recognition.
Study provides evidence that a loss-of-function variant rs10553596 in CASP7 associates with significantly reduced Alzheimer's disease incidence in elder populations.
Thymoquinone-triggered apoptosis was substantiated by up-regulation of the executioner caspase-3 (show CASP3 Proteins) and caspase-7, as well as cleavage of the death substrate poly(ADP-ribose)polymerase (show PARP1 Proteins).
Casp3 (show CASP3 Proteins)/7-Instructed Intracellular Aggregation of Fe3O4 Nanoparticles Enhances T2 MR Imaging of Tumor Apoptosis.
Low expression of CASP7 is associated with non-small cell lung cancer.
this report suggests a novel finding that cellular signaling caspase 3 (show CASP3 Proteins)/7-PKCdelta (show PKCd Proteins)-Akt (show AKT1 Proteins)/p38 MAPK (show MAPK14 Proteins) is crucial to the repopulation in Panc1 cells after radiotherapy.
18)F-C-SNAT (show AANAT Proteins) has significantly increased tumor uptake and significantly increased tumor-to-muscle ratio in a preclinical mouse model of tumor therapy.
mRNA expression of Bax (show BAX Proteins), Bcl-2 (show BCL2 Proteins), caspase-3 (show CASP3 Proteins) and-7 cannot be used as a reliable apoptosis detection method.
the capacity for blastocysts to undergo further development is related to degree of group II caspase (show CASP3 Proteins) activity
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, caspase 7
, apoptotic protease Mch-3
, cysteine protease LICE2
, ICE-like apoptotic protease 3
, apoptotic protease MCH-3
, caspase 7, apoptosis-related cysteine protease
, Apoptotic protease Mch-3
, SREBP cleavage activity 2