anti-Human Cytochrome C antibody for Neutralization

Recommended Cytochrome C Antibody (supplied by: Log in to see )

Antigen
Cytochrome C, Somatic (CYCS) Antibodies
  • CYC
  • HCS
  • THC4
  • cyct
  • cyc
  • hcs
  • CYCS
  • cytc
  • CYCSA
  • CG17903
  • Cyt C
  • Cyt c
  • Cyt-c2
  • CytC-2
  • Cytc
  • Cytc-p
  • DC4
  • DMc01
  • Dmel\\CG17903
  • cyt c
  • cyt c-p
  • cyt-c-p
  • cyt-c2
  • cyt.c
  • cytochrome c
  • dc4
  • pDMc01
  • wu:fk52b01
  • zgc:86706
  • cytochrome c, somatic
  • cytochrome c, somatic S homeolog
  • Cytochrome c proximal
  • cytochrome c, somatic b
  • cytochrome c-like
  • cytochrome c
  • CYCS
  • cycs.S
  • cycs
  • Cycs
  • Cyt-c-p
  • cycsb
  • LOC100724240
  • CYC
  • LOC100847700
  • LOC101107954
  • LOC106829744
  • LOC106992390
Reactivity
Human, Mouse (Murine), Rat (Rattus)
393
329
236
116
94
82
47
38
34
31
25
25
24
20
12
11
8
8
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Host
Mouse
281
163
7
3
Clonality
Monoclonal
Conjugate
This Cytochrome C antibody is un-conjugated
20
12
12
7
7
7
6
6
5
5
5
4
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Neutralization (Neut)
354
177
148
124
115
73
49
42
40
26
23
13
6
4
4
4
4
4
3
3
3
2
1
1
1
1
1
1
1
1
1
1
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Pubmed
10 references available

Available images

Immunofluorescence (IF) image for anti-Cytochrome C, Somatic (CYCS) antibody (ABIN2666071)
Western Blotting (WB) image for anti-Cytochrome C, Somatic (CYCS) antibody (ABIN2666071)
Catalog No. ABIN2666071
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
4 ABIN207924 IHC IHC (fro) IP Neut Mouse IgG1 Log in to see 6H2-B4 0
1 ABIN2666072 Neut Mouse IgG1 kappa Log in to see 6H2-B4 10

General

Antigen Cytochrome C, Somatic (CYCS) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(393), (329), (236), (116), (94), (82), (47), (38), (34), (31), (25), (25), (24), (20), (12), (11), (8), (8), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host Mouse
(281), (163), (7), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Cytochrome C antibody is un-conjugated
(20), (12), (12), (7), (7), (7), (6), (6), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Neutralization (Neut)
(354), (177), (148), (124), (115), (73), (49), (42), (40), (26), (23), (13), (6), (4), (4), (4), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 10 references available
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Product Details anti-Cytochrome C Antibody

Target Details Cytochrome C Application Details Handling References for anti-Cytochrome C antibody (ABIN2666071) Images
Purification The antibody was purified by affinity chromatography.
Clone 6H2-B4
Isotype IgG1 kappa
Plasmids, Primers & others

Target Details Cytochrome C

Product Details anti-Cytochrome C Antibody Application Details Handling References for anti-Cytochrome C antibody (ABIN2666071) Images back to top
Antigen
Alternative Name Cytochrome C (CYCS Antibody Abstract)
Background Cytochrome c is a 15 kD protein found in the mitochondrial intermembrane space with a heme-binding domain. Cytochrome c is a component of the electron transport chain, the heme group transfers electrons from cytochrome b-c1 complex to cytochrome oxidase complex. Cytochrome c initiates apoptosis by release to cytoplasm and binding Apaf-1 which activates procaspase 9. Cytochrome c interacts with the cytochrome b-c1 complex, cytochrome oxidase complex, heme, Apaf-1, and Caspase 9 proteins. The 6H2.B4 monoclonal antibody recognizes human, mouse, and rat cytochrome-c and has been shown to be useful for intracellular flow cytometric staining, Western blotting, immunoprecipitation, and immunofluorescence staining.
Pathways Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Handling References for anti-Cytochrome C antibody (ABIN2666071) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Application Details References for anti-Cytochrome C antibody (ABIN2666071) Images back to top
Concentration 0.5 mg/mL
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide. Final antibody concentration is 0.5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Upon receipt, store between 2°C and 8°C.

References for anti-Cytochrome C antibody (ABIN2666071)

Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Application Details Handling Images back to top
Background publications

McGuire, Barlan, Griffin, Wiethoff: "Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species." in: Journal of virology, Vol. 85, Issue 20, pp. 10806-13, 2011

She, Zhang, Marchionini, Diaz, Jetton, Kimball, Vary, Lang, Lynch: "Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 1, pp. E49-61, 2011

Ferguson, Marietta, Van Den Berg: "UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells: a model for cytochrome c resistance." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 45793-800, 2003

Zhang, Gerstein: "The human genome has 49 cytochrome c pseudogenes, including a relic of a primordial gene that still functions in mouse." in: Gene, Vol. 312, pp. 61-72, 2003

Semenkova, Dudich, Dudich, Tokhtamisheva, Tatulov, Okruzhnov, Garcia-Foncillas, Palop-Cubillo, Korpela: "Alpha-fetoprotein positively regulates cytochrome c-mediated caspase activation and apoptosome complex formation." in: European journal of biochemistry / FEBS, Vol. 270, Issue 21, pp. 4388-99, 2003

Chandra, Liu, Tang: "Early mitochondrial activation and cytochrome c up-regulation during apoptosis." in: The Journal of biological chemistry, Vol. 277, Issue 52, pp. 50842-54, 2002

Shih, Wu, Hung, Yang, Lin: "Abrin triggers cell death by inactivating a thiol-specific antioxidant protein." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21870-7, 2001

Liu, Kim, Yang, Jemmerson, Wang: "Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c." in: Cell, Vol. 86, Issue 1, pp. 147-57, 1996

Goshorn, Retzel, Jemmerson: "Common structural features among monoclonal antibodies binding the same antigenic region of cytochrome c." in: The Journal of biological chemistry, Vol. 266, Issue 4, pp. 2134-42, 1991

Jemmerson, Johnson, Burrell, Taylor, Jenkins: "A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen-presenting cells." in: European journal of immunology, Vol. 21, Issue 1, pp. 143-51, 1991

Images

Product Details anti-Cytochrome C Antibody Target Details Cytochrome C Application Details Handling References for anti-Cytochrome C antibody (ABIN2666071) back to top
Supplier Images
Immunofluorescence (IF) image for anti-Cytochrome C, Somatic (CYCS) antibody (ABIN2666071) anti-Cytochrome C, Somatic (CYCS) antibody
Western Blotting (WB) image for anti-Cytochrome C, Somatic (CYCS) antibody (ABIN2666071) anti-Cytochrome C, Somatic (CYCS) antibody (Image 2)