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|Antigen||DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB) Antibodies|
|Conjugate||This DFFB antibody is un-conjugated Alternatives|
Dot Blot (DB)
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Product Details anti-DFFB AntibodyTarget Details DFFB Application Details Handling Images
|Cross-Reactivity (Details)||Other species not studied.|
|Purification||Protein G affinity chromatography|
|Immunogen||DFFB antibody was raised in mouse using recombinant Human Dna Fragmentation Factor, 40 Kda, Beta Polypeptide (Caspase-Activated Dnase) (Dffb)|
Target Details DFFBProduct Details anti-DFFB Antibody Application Details Handling Images back to top
|Alternative Name||DFFB (DFFB Antibody Abstract)|
|Background||DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene. Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40kDa (DFFB) and 45kDa (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. Synonyms: Monoclonal DFFB antibody, Anti-DFFB antibody, DNA fragmentation factor subunit beta antibody, CAD antibody, CPAN antibody, DFF2 antibody, DFF40 antibody, DFF-40 antibody.|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-DFFB Antibody Target Details DFFB Handling Images back to top
|Application Notes||Optimal conditions should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-DFFB Antibody Target Details DFFB Application Details Images back to top
|Buffer||DFFB antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).|
|Precaution of Use||This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.|
ImagesProduct Details anti-DFFB Antibody Target Details DFFB Application Details Handling back to top