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Human Polyclonal DIABLO Primary Antibody for ICC, IF - ABIN252299
Yoo, Kim, Kim, Park, Park, Jeon, Jung, Lee, Lee: Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas. in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003
Show all 16 Pubmed References
Human Monoclonal DIABLO Primary Antibody for ICC, IF - ABIN153019
Wang, Zhu, Drozda, Zhang, Stavrovskaya, Cattaneo, Ferrante, Kristal, Friedlander: Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. in Proceedings of the National Academy of Sciences of the United States of America 2003
Show all 9 Pubmed References
Mouse (Murine) Monoclonal DIABLO Primary Antibody for ELISA, FACS - ABIN4354647
Tikoo, OReilly, Day, Verhagen, Pakusch, Vaux: Tissue distribution of Diablo/Smac revealed by monoclonal antibodies. in Cell death and differentiation 2002
Show all 3 Pubmed References
Human Polyclonal DIABLO Primary Antibody for IHC, WB - ABIN223042
Haudek, Taffet, Schneider, Mann: TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways. in The Journal of clinical investigation 2007
Show all 2 Pubmed References
Human Polyclonal DIABLO Primary Antibody for IF (p), IHC (p) - ABIN674619
Liu, Chen, Li, Wang, Cheng: Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts. in International journal of molecular medicine 2013
Human Polyclonal DIABLO Primary Antibody for IHC, IHC (p) - ABIN4354640
Krajewska, Kim, Kim, Kang, Welsh, Matsuzawa, Tsukamoto, Thomas, Assa-Munt, Piao, Suzuki, Perucho, Krajewski, Reed: Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers. in Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Human Polyclonal DIABLO Primary Antibody for ELISA, ICC - ABIN4354645
Sulaiman, Chu, Blanco, Vallabhapurapu, Franco, Qi: SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas. in Molecular cancer 2015
Human Polyclonal DIABLO Primary Antibody for IHC (p), WB - ABIN2476525
McLeod: The sweet life. in Nursing times 1975
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Human Polyclonal DIABLO Primary Antibody for IHC (p), WB - ABIN2476526
Verhagen, Coulson, Vaux: Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. in Genome biology 2001
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We report that an Smac-mimetic selectively induces TNF-alpha (show TNF Antibodies)-dependent cystic renal epithelial cell death, leading to the removal of cystic epithelial cells from renal tissues and delaying cyst formation.
Results demonstrate an essential and apoptosis-independent function of SMAC in tumor suppression and provide new insights into the biology and targeting of colon cancer.
Identification of a novel anti-apoptotic E3 ubiquitin ligase (show MUL1 Antibodies) that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2 (show HTRA2 Antibodies), and ARTS.
Loss of Smac/DIABLO alters both caspase (show CASP3 Antibodies)-dependent and caspase (show CASP3 Antibodies)-independent intrinsic programmed cell death.
Membrane-associated XIAP (show XIAP Antibodies) induces mitochondrial outer membrane permeabilization leading to cytochrome c (show CYCS Antibodies) and Smac release, which is dependent on Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies).
data suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac/DIABLO function.
mitochondrial activation by Bid (show BID Antibodies) is required for reversing the inhibitor-of-apoptosis proteins inhibition through Smac release
Diablo was present within the mitochondria of healthy cells, but released into the cytosol following the induction of apoptosis by UV.
Transient focal ischemia was produced for 1 hour in mice. Mitochondrial levels of DIABLO increased after 2-11 h reperfusion. DIABLO increased in the cytosol after 5 h reperfusion, implying the translocation of DIABLO into the cytosol.
Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies) differentially regulate the release of cytochrome c (show CYCS Antibodies) and Smac/DIABLO from mitochondria, and Smac/DIABLO can be used to sensitize cells that are deficient in Bax (show BAX Antibodies) and Bak (show BAK1 Antibodies) genes, or resistant to TRAIL.
administration of SMAC or BH3 mimetics following short-term paclitaxel treatment could be an effective therapeutic strategy for TNBC, while only BH3-mimetics could effectively overcome long-term paclitaxel resistance.
Antagonism strategies to modulate the actions of XIAP (show XIAP Antibodies), cIAP1 (show BIRC2 Antibodies)/2 and survivin (show BIRC5 Antibodies) are the central focus of current research and this review highlights advances within this field with particular emphasis upon the development and specificity of second mitochondria-derived activator of caspase (SMAC) mimetics (synthetic analogs of endogenously expressed inhibitors of IAPs SMAC/DIABLO).
analysis of Smac-mediated apoptosis in chronic lymphocytic leukemia cells
Data show that oncolytic viruses (OV) and second mitochondrial activator of caspase (show CASP3 Antibodies) (Smac)-mimetic compounds (SMC (show DYM Antibodies)) synergistically kill cancer cells directly.
Expressions of SDF-1 (show CXCL12 Antibodies), survivin (show BIRC5 Antibodies) and smac were significantly higher in epithelial ovarian cancer tissue than those in normal tissue.
Results indicate that Smac plays an important role in reticulum stress-induced apoptosis in human lens epithelial cells, suggesting its close association with cataract development.
Smac mimetic APG (show SMAD1 Antibodies)-1387 exerts a potent antitumor effect on nasopharyngeal carcinoma cells by inducing apoptosis.
These results reveal a pro-apoptotic function of PARL (show PARL Antibodies) and identify PARL (show PARL Antibodies)-mediated Smac processing and cytochrome c (show CYCS Antibodies) release facilitated by OPA1 (show OPA1 Antibodies)-dependent cristae remodelling as two independent pro-apoptotic pathways in mitochondria.
Study found a negative correlation between Smac and XIAP (show XIAP Antibodies) at the level of protein but not mRNA in non-small cell lung carcinoma (NSCLC) patients. Overexpressed XIAP (show XIAP Antibodies) could degrade through ubiquitination, the mature Smac inhibiting NSCLC apoptosis.
Report role of RIP1 (show UQCRFS1 Antibodies) in Smac mimetic mediated chemosensitization of neuroblastoma (show ARHGEF16 Antibodies) cells.
hyperosmotic shock induces rapid calpain activation and high levels of Smac/DIABLO release from the mitochondria before significant amounts of cytochrome c (show CYCS Antibodies) are released to promote caspase-3 (show CASP3 Antibodies) activation
Identification of the third vertebrate homologue of Smac/DIABLO.
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.
Direct IAP-binding protein with low pI
, diablo homolog, mitochondrial
, second mitochondria-derived activator of caspase
, direct IAP binding protein with low PI
, direct IAP-binding protein with low pI
, diablo homolog
, mitochondrial diablo-like protein
, mitochondrial diablo
, second mitochondrial derived activator of caspases
, Second mitochondria-derived activator of caspase