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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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1 | ABIN2421567 | IHC ELISA WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN1086062 | IHC ELISA WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN1086063 | IHC ELISA WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN2428121 | IHC ELISA | Rabbit | IgG | Log in to see | Polyclonal | 0 |
General |
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Antigen | Fas (TNFRSF6)-Associated Via Death Domain (FADD) Antibodies |
Reactivity | Human, Mouse (Murine), Rat (Rattus) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This FADD antibody is un-conjugated Alternatives |
Application |
Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
Alternatives
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Supplier | Log in to see |
Product Details anti-FADD AntibodyTarget Details FADD Application Details Handling Images |
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Cross-Reactivity | Mouse (Murine), Rat (Rattus) |
Purification | Antibody was purified by immunogen affinity chromatography. |
Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within human FADD. |
Target Details FADDProduct Details anti-FADD Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | FADD (FADD Antibody Abstract) |
Background |
Alternate Names: FADD, Protein FADD, Fas-associated protein with death domain, FAS-associated death domain protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity, Growth-inhbiting gene 3 protein, MORT1 Description: FAS-associated death domain protein (FADD) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. FADD is involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. Defects in FADD are the cause of recurrent infections associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM). IEHDCM is a condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4-CD8-TCR-alpha-beta+ T-cell counts, and elevated IL10 and FASL levels. |
UniProt | Q13158 |
Pathways | Apoptosis, TLR Signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades |
Application DetailsProduct Details anti-FADD Antibody Target Details FADD Handling Images back to top |
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Application Notes | E: 1:500-1:1,000, WB: 1:100-1:500, IHC: 1:100-1:500, IP: 1:100-1:500 |
Restrictions | For Research Use only |
HandlingProduct Details anti-FADD Antibody Target Details FADD Application Details Images back to top |
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Format | Liquid |
Concentration | 1 mg/mL |
Buffer | Each vial contains 0.1 mg IgG in 0.1 mL (1 mg/mL) of PBS pH 7.4 with 0.09 % sodium azide. |
Preservative | Sodium azide |
Precaution of Use | Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains. |
Handling Advice | Minimize freeze-thaw cycles. |
Storage | -20 °C |
Storage Comment | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
Expiry Date | 12 months |