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|Antigen||Fas (TNFRSF6)-Associated Via Death Domain (FADD) Antibodies|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This FADD antibody is conjugated to Alexa Fluor 488 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
|Supplier||Log in to see|
Product Details anti-FADD AntibodyTarget Details FADD Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from rat protein FADD around the phosphorylation site of Ser194|
Target Details FADDProduct Details anti-FADD Antibody Application Details Handling Images back to top
|Alternative Name||Fadd (FADD Antibody Abstract)|
FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C terminal death domain that interacts with the Fas receptor death domain. The N terminus contains a death effectors domain (DED) which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, which in turn drives its autoactivation through self-cleavage. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby commiting the cell to undergo apoptosis. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL induced transcriptional activation of cfos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK 293 cell line.
Synonyms: FADD phospho S194, p-FADD phospho S194, P-Fas-associated protein with death domain, FADD protein, Fas TNFRSF6 associated via death domain, Fas associated via death domain, Fas associating death domain containing protein, Fas associating protein, Fas associating protein with death domain, Fas TNFRSF6 associated via death domain, GIG 3, GIG3, Growth inhibiting gene 3 protein, H sapiens mRNA for mediator of receptor induced toxicity, Mediator of receptor induced toxicity , MGC8528 , MORT 1, MORT1.
|Research Area||Cancer, Apoptosis/Necrosis|
|Pathways||Apoptosis, TLR Signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-FADD Antibody Target Details FADD Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-FADD Antibody Target Details FADD Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|