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|Antigen||Fas Ligand (TNF Superfamily, Member 6) (FASL) Antibodies|
|Reactivity||Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This FASL antibody is un-conjugated Alternatives|
Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-FASL AntibodyTarget Details FASL Application Details Handling Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412731|
Detects ~31 kDa FasL in samples of mouse and rat origins.
A ~70 kDa band, possible represents the FasL and Fas complex can also be detected.
|Immunogen||Synthetic peptide mapping to the C-terminus of rat FasL|
Target Details FASLProduct Details anti-FASL Antibody Application Details Handling Images back to top
|Alternative Name||FasL (FASL Antibody Abstract)|
Fas/Apo-1/CD95 is a cell surface type-I membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS-PAGE. Fas is a member of the TNFR family that includes TNFR1, TNFR2, CD27, CD30, and CD40. Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis in Fas expressing cells. Both Fas and TNF-R contain the 70 amino acids cytoplasmic "death domain" that is responsible for transmitting signal for apoptosis.
Synonyms: FASLG, FASL , FasL, CD95L , APT1LG1, CD178 , APTL , TNFSF6
|Research Area||CD Antigens, Surface Receptors of Immune Cells, Apoptosis/Necrosis, Virology, Cancer|
|Pathways||Apoptosis, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity|
Application DetailsProduct Details anti-FASL Antibody Target Details FASL Handling Images back to top
|Application Notes||Western blotting (0.5-4 μg/mL). However, the optimal conditions should be determined individually. Detects ~31 kDa FasL in samples of mouse and rat origins. A ~70 kDa band, possible represents the FasL and Fas complex can also be detected|
|Restrictions||For Research Use only|
HandlingProduct Details anti-FASL Antibody Target Details FASL Application Details Images back to top
|Buffer||100 μg (0.5 mg/mL) affinity purified rabbit anti-FasL polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||The antibody solution should be gently mixed before use.|
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
ImagesProduct Details anti-FASL Antibody Target Details FASL Application Details Handling back to top