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demonstration of presence of FAS and FASL in the equine corpus luteum throughout the luteal phase
FasL -844C>T polymorphism plays a protective role against Head and Neck Cancer development in Asian population.
The Fas (show FAS Proteins) mRNA expression ratio was unchanged upon MTX (show MTX1 Proteins) treatment, but the FasL mRNA expression ratio was significantly higher in MTX (show MTX1 Proteins)-treated than nontreated polyps. In addition, the expression levels of the Fas (show FAS Proteins) and FasL proteins were significantly higher in polyps treated with both 10 and 100 muM MTX (show MTX1 Proteins) compared with nontreated polyps.
High-grade gliomas (HGG) showed significantly lower FAS (show FAS Proteins) but higher FAS ligand (FAS-L) expression than high-grade gliomas (HGG).
Results show that the FasL:Fas complex shares structural features with the FasL:DcR3 assembly and the glycosylation contributes to the activity of soluble FasL
The dysregulation of ADAM10 (show ADAM10 Proteins), Fas (show FAS Proteins) and FasL could be useful indicators of the progression and severity of OSCC.
FASLG c.-844TC genotype may be protective against familial mediterranean fever (show MEFV Proteins) in the Turkish population.
The rs763110 TT genotype significantly increased the risk of cervical cancer compared with the CC/CT genotype. Patients carrying this genotype presented a lower cancerous FASL expression than that of the CC/CT genotypes. OCT1 (show POU2F1 Proteins) was recruited to the FASL promoter region and regulated the FASL gene transcription by interacting with C/EBPbeta (show CEBPB Proteins).
Inhibition of miR-149-5p can induce apoptosis in THP-1 cells. These inductive effects might be via targeting FASLG and activating FADD and caspases.
FasL gene polymorphism is associated with Hashimoto's thyroiditis.
There is a positive correlation of the serum level of sFasL ( Fas (show FAS Proteins)/FasL axis )with uptake index of parotid gland in our expectation. In addition, liver injury involvement in SS patients showed decreased level of sFasL. Furthermore, we here also observed that the protective cytokine IL-10 (show IL10 Proteins) expression was positively correlated with sFasL expression
Hrd1 (show SYVN1 Proteins)-null B cells exhibited high Fas (show FAS Proteins) expression during activation and rapidly underwent Fas (show FAS Proteins)-mediated apoptosis, which could be largely inhibited by FasL neutralization. Fas (show FAS Proteins) mutation in Hrd1 (show SYVN1 Proteins) KO mice abrogated the increase in B-cell AICD. We identified Hrd1 (show SYVN1 Proteins) as the first E3 ubiquitin ligase (show MUL1 Proteins) of the death receptor Fas (show FAS Proteins) and Hrd1 (show SYVN1 Proteins)-mediated Fas (show FAS Proteins) destruction as a molecular mechanism in regulating B-cell immunity.
this study suggests that FasL gene polymorphisms in peripheral blood might be accurate in detecting cellular acute rejection following pediatric renal transplantation
CD3 (show CD3E Proteins)(+) CD8 (show CD8A Proteins)(+) NKG2D (show KLRK1 Proteins)(+) T Lymphocytes Induce Apoptosis and Necroptosis in HLA-Negative Cells via FasL-Fas (show FAS Proteins) Interaction
this study shows that the -844T/C polymorphism in the FasL gene confers risk to hepatocellular carcinoma in Egyptian patients
It has been shown that treatment with anti-FasL prevents lymphocyte apoptosis, upregulates type-1 responses to Trypanosoma cruzi antigens, and reduces infection in macrophages cocultured with activated CD8 (show CD8A Proteins) T cells.
Here the authors show using an autoperfused flow chamber assay of whole blood neutrophils and intravital microscopy of the inflamed cremaster muscle that CD95 (show FAS Proteins) mediates leukocyte slow rolling, adhesion and transmigration upon binding of CD95-ligand (CD95L) that is presented by endothelial cells.
FasL expression in splenic CD5 (show CD5 Proteins)(+)CD1d (show CD1D Proteins)(hi) B cells was decreased compared to the control group after TLR4 (show TLR4 Proteins) ligation.
The interaction of Fas receptor (show FAS Proteins) with FasL leads to an activation of the Tag7 (show PGLYRP1 Proteins)-Hsp70 (show HSP70 Proteins) complex in the lymphocyte membrane fraction, and here FasL acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA (show MICA Proteins) stress ligand with the NKG2D (show KLRK1 Proteins) receptor is necessary for the release of this cytotoxic complex
this study shows that one-time intraocular adeno (show ADORA2A Proteins)-associated virus-mediated gene delivery of soluble FasL provides complete and sustained neuroprotection in the models of glaucoma
Study found that propofol anesthesia activates Fas (show FAS Proteins)/FasL-mediated extrinsic and Bcl-2 (show BCL2 Proteins)-dependent intrinsic apoptotic pathways, resulting in caspase-8 (show CASP8 Proteins) and caspase-9 (show CASP9 Proteins) activations, respectively, and established upregulation of caspase-1 (show CASP1 Proteins) and IL-1beta (show IL1B Proteins) cytokine transcriptions as well as subsequent activation of microglia. Behavioral data revealed that hyperactivity persists through adolescence and young adulthood.
Data suggest forkhead box protein O1 (FoxO1 (show FOXO1 Proteins)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Proteins) and Fas ligand FasL expression during follicular atresia.
FasL was not detected on fetal pig pancreatic cells but could be induced on both beta and non-beta cells when the cells were treated with IL1beta (show IL1B Proteins).
The expression of FAS (show FAS Proteins) and FAS ligand in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported
the result indicates that the expression of FasL by chondrocytes is capable of inducing apoptosis of activated T cells
The present results may provide some insights to understand the role of Fas (show FAS Proteins)/FasL in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury.
It was concluded that the Fas (show FAS Proteins)-FasL signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B (show TDO2 Proteins) cell lymphoma/leukemia-2 associated X upregulation.
activation of the Fas (show FAS Proteins) pathway and presence of FSH (show BRD2 Proteins) during in vitro maturation increased the incidence of apoptosis in cumulus cells
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).
, fas ligand receptor soluble form
, tumor necrosis factor receptor superfamily member 6
, Fas ligand (TNF superfamily, member 6)
, Fas (TNF receptor superfamily, member 6)
, Fas antigen
, tumor necrosis factor receptor superfamily, member 6
, tumor necrosis factor ligand superfamily member 6
, apoptosis (APO-1) antigen ligand 1
, CD95 ligand
, apoptosis antigen ligand
, fas antigen ligand
, tumor necrosis factor (ligand) superfamily, member 6
, Fas antigen ligand
, generalized lymphoproliferative disease
, Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)
, CD95L protein
, Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
, Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
, FAS antigen CD95
, APO-1 ligand
, TNF superfamily, member 6