|Antigen||Keratin 18 (KRT18) Antibodies|
|Reactivity||Bird (Avian), Dog (Canine), Chicken, Human, Mammalian, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus) Alternatives|
|Conjugate||This KRT18 antibody is un-conjugated Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-KRT18 AntibodyTarget Details KRT18 Application Details Handling Images
|Specificity||The antibody is useful for the discrimination of adenocarcinomas and mesotheliomas from squamous cell carcinomas and non-epithelial tumors. Clone RGE 53 specifically recognizes simple and glandular epithelial cells from the gastrointestinal tract, the respiratory tract and the urogenital tract, as well as endocrine and exocrine tissues and myoepithelial cells. In the transitional epithelium of the bladder RGE 53 reacts only with superficial (umbrella) cells. No reaction with stratified squamous epithelia. Polypeptide Reacting: 45 kDa Keratin K18 (formerly also designated Cytokeratin 18).|
|Characteristics||Synonyms: Cytokeratin-18, CK18, Keratin-18, Keratin 18, KRT18, CYK18, K18, Cell proliferation-inducinggene 46 protein, Keratin type I cytoskeletal 18|
|Immunogen||Isolated from HeLa cells|
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|Alternative Name||Cytokeratin 18 (KRT18 Antibody Abstract)|
|Background||Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18.Synonyms: CK18, CYK18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, K18, KRT18, Keratin 18, Keratin type I cytoskeletal 18, Keratin-18|
|Research Area||Signaling, Cytoskeleton, Extracellular Matrix|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-KRT18 Antibody Target Details KRT18 Handling Images back to top
Immunoblotting. Immunofluorescence. Immunohistochemistry. Suitable for frozen sections. Working dilution 1: 5 - 1: 10, dilute immediately before use with PBS or TBS. Recommended positive control: Adenocarcinoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
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