anti-Human KRT18 antibody for Biochemical Assay

Recommended KRT18 Antibody

Antigen
Keratin 18 (KRT18) Antibodies
  • CK18
  • K18
  • Krt1-18
  • CYK18
  • DreK18
  • cb83
  • dapk1
  • sb:cb83
  • wu:fa13f02
  • wu:fb36b04
  • krt18
  • MGC64569
  • MGC75922
  • KRT18
  • keratin 18
  • keratin 18, type I L homeolog
  • keratin 18, type I
  • keratin, type I cytoskeletal 18
  • K18, simple type I keratin
  • Keratin, type I cytoskeletal 18
  • Krt18
  • KRT18
  • krt18
  • krt18.L
  • LOC700569
  • LOC100136778
  • k1c18
  • LOC100008885
Reactivity
Human
928
225
217
127
96
67
65
52
48
38
36
33
33
33
25
15
11
9
6
4
3
2
1
1
1
1
Host
Mouse
615
340
14
13
5
2
2
Clonality
Monoclonal
Conjugate
This KRT18 antibody is un-conjugated
56
41
18
11
11
11
11
11
11
10
9
9
8
8
8
8
8
8
8
8
8
8
8
8
8
8
3
3
3
3
3
2
1
Application
Biochemical Assay (BCA)
596
404
378
375
259
200
171
98
82
79
42
40
30
18
14
11
2
1
1
1
Options

Available images

Catalog No. ABIN2664917
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Clonality References Details
1 ABIN2664918 BCA Mouse IgG1 kappa DA-7 5

General

Antigen Keratin 18 (KRT18) Antibodies
Reactivity Human
(928), (225), (217), (127), (96), (67), (65), (52), (48), (38), (36), (33), (33), (33), (25), (15), (11), (9), (6), (4), (3), (2), (1), (1), (1), (1)
Host Mouse
(615), (340), (14), (13), (5), (2), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This KRT18 antibody is un-conjugated
(56), (41), (18), (11), (11), (11), (11), (11), (11), (10), (9), (9), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (3), (3), (3), (3), (3), (2), (1)
Application Biochemical Assay (BCA)
(596), (404), (378), (375), (259), (200), (171), (98), (82), (79), (42), (40), (30), (18), (14), (11), (2), (1), (1), (1)
Pubmed 5 references available
Supplier

Product Details anti-KRT18 Antibody

Target Details KRT18 Application Details Handling References for anti-KRT18 antibody (ABIN2664917) Images
Purification The antibody was purified by affinity chromatography.
Clone DA-7
Isotype IgG1 kappa
Plasmids, Primers & others

Target Details KRT18

Product Details anti-KRT18 Antibody Application Details Handling References for anti-KRT18 antibody (ABIN2664917) Images back to top
Antigen
Alternative Name Cytokeratin 18 (KRT18 Antibody Abstract)
Background Cytokeratin 18, also known as keratin 18, is a type I intermediate filament protein with a molecular weight of approximately 48 kD. Cytokeratin 18 is a heterotetramer composed of two type I and two type II keratins. Cytokeratin 18 associates with cytokeratin 8 and is widely expressed in simple epithelial tissues in adults, where it is found in the cytoplasm, nucleus, and nucleolus. Cytokeratin 18 is associated with the cytoskeleton and mutations in this protein have been associated with liver disease after environmental insult. Cytokeratin 18 can be modified by glycosylation, phosphorylation (Ser34 and Ser53), acetylation (Ser2), and proteolytic cleavage at amino acids 238 and 397 by caspase family members. The cytokeratin 18 protein interacts with a number of proteins including caspase 3, 14-3-3 gamma, 14-3-3 zeta, 14-3-3 sigma 14-3-3 beta, 14-3-3 eta, keratin 5, keratin 8, TNF receptor II, plakophilin 2, EGF receptor, and usherin, among others.
Pathways Apoptosis, Caspase Cascade in Apoptosis

Application Details

Product Details anti-KRT18 Antibody Target Details KRT18 Handling References for anti-KRT18 antibody (ABIN2664917) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-KRT18 Antibody Target Details KRT18 Application Details References for anti-KRT18 antibody (ABIN2664917) Images back to top
Concentration 0.5 mg/mL
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide at 0.5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-KRT18 antibody (ABIN2664917)

Product Details anti-KRT18 Antibody Target Details KRT18 Application Details Handling Images back to top
Background publications

Ku, Darling, Krams, Esquivel, Keeffe, Sibley, Lee, Wright, Omary: "Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 10, pp. 6063-8, 2003

Taylor-Papadimitriou, Stampfer, Bartek, Lewis, Boshell, Lane, Leigh: "Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium." in: Journal of cell science, Vol. 94 ( Pt 3), pp. 403-13, 1990

Kulesh, Oshima: "Complete structure of the gene for human keratin 18." in: Genomics, Vol. 4, Issue 3, pp. 339-47, 1989

Lauerová, Kovarik, Bártek, Rejthar, Vojt?sek: "Novel monoclonal antibodies defining epitope of human cytokeratin 18 molecule." in: Hybridoma, Vol. 7, Issue 5, pp. 495-504, 1989

Steinert, Roop: "Molecular and cellular biology of intermediate filaments." in: Annual review of biochemistry, Vol. 57, pp. 593-625, 1988

Images

Product Details anti-KRT18 Antibody Target Details KRT18 Application Details Handling References for anti-KRT18 antibody (ABIN2664917) back to top
Supplier Images
Immunofluorescence (IF) image for anti-Keratin 18 (KRT18) antibody (ABIN2664917) anti-Keratin 18 (KRT18) antibody
Immunofluorescence (IF) image for anti-Keratin 18 (KRT18) antibody (ABIN2664917) anti-Keratin 18 (KRT18) antibody (Image 2)
Western Blotting (WB) image for anti-Keratin 18 (KRT18) antibody (ABIN2664917) anti-Keratin 18 (KRT18) antibody (Image 3)