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anti-Human Lamin A/C Antibodies:
anti-Mouse (Murine) Lamin A/C Antibodies:
anti-Rat (Rattus) Lamin A/C Antibodies:
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Human Polyclonal Lamin A/C Primary Antibody for IHC, WB - ABIN6672084
Ye, Jiang, Cui, Zhu, Sun, Wang, Zohaib, Dong, Ruan, Song, He, Chen, Cao: Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis. in The Journal of infectious diseases 2014
Show all 11 Pubmed References
Mouse (Murine) Polyclonal Lamin A/C Primary Antibody for IHC, WB - ABIN3020785
Wei, Dai, Zhou, He, Yao, Zhao, Guo, Yang: Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. in Cell death & disease 2018
Show all 11 Pubmed References
Human Monoclonal Lamin A/C Primary Antibody for ICC, FACS - ABIN335389
Broers, Machiels, Kuijpers, Smedts, van den Kieboom, Raymond, Ramaekers: A- and B-type lamins are differentially expressed in normal human tissues. in Histochemistry and cell biology 1997
Show all 10 Pubmed References
Green monkey (Chlorocebus) Monoclonal Lamin A/C Primary Antibody for ICC, FACS - ABIN303591
Vaughan, Alvarez-Reyes, Bridger, Broers, Ramaekers, Wehnert, Morris, Whitfield WGF, Hutchison: Both emerin and lamin C depend on lamin A for localization at the nuclear envelope. in Journal of cell science 2001
Show all 8 Pubmed References
Human Polyclonal Lamin A/C Primary Antibody for IF, IHC - ABIN6712003
Chen, Wang, Lu, Zhang, Fu, Luo: Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. in Blood 2011
Show all 5 Pubmed References
Human Polyclonal Lamin A/C Primary Antibody for FACS, ICC - ABIN4330008
Kiel, Busch, Meyer-Rachner, Hübner: Laminopathy-inducing mutations reduce nuclear import of expressed prelamin A. in The international journal of biochemistry & cell biology 2014
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Human Polyclonal Lamin A/C Primary Antibody for ICC, IHC (p) - ABIN3043695
Liu, Ma, Wu, Li, Zhang, Han, Wang, Reindl, Wu, Ma: Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-?B signaling. in BMC cancer 2014
Show all 3 Pubmed References
Human Monoclonal Lamin A/C Primary Antibody for ICC, FACS - ABIN335390
Neri, Raymond, Giordano, Borgatti, Marchisio, Capitani, Martelli: Spatial distribution of lamin A and B1 in the K562 cell nuclear matrix stabilized with metal ions. in Journal of cellular biochemistry 1999
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Human Polyclonal Lamin A/C Primary Antibody for WB - ABIN537492
Lei, Liu, Sodja, LeBlanc, Ribecco-Lutkiewicz, Smith, Charlebois, Walker, Sikorska: S/MAR-binding properties of Sox2 and its involvement in apoptosis of human NT2 neural precursors. in Cell death and differentiation 2005
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Human Polyclonal Lamin A/C Primary Antibody for ICC, IHC (p) - ABIN3043295
Yang, Liu, Zhu, Zhang, Xi, Hu, He, Jiang: Human peripheral nerve-derived scaffold for tissue-engineered nerve grafts: histology and biocompatibility analysis. in Journal of biomedical materials research. Part B, Applied biomaterials 2010
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Study found that K219T LMNA mutation specifically affects expression of the sodium channel Nav1.5 via an epigenetic mechanism involving interplay with Polycomb Group protein SUZ12 and targeting of the expression of the gene encoding this channel, SCN5A and identify a cause-effect link between a Lamin A/C mutation, altered Nav1.5 expression and conduction abnormalities associated with LMNA-cardiomyopathy.
In summary, we show that the expression of lamin A/C, a component of nuclear lamina, is specifically upregulated in obese adipose tissue, which is largely attributed to adipose tissue macrophages.
A deleterious LMNA mutation was identified in a family with dilated cardiomyopathy.
This study reveals mechanisms underlying progerin toxicity, including replication stress-induced genomic instability and activation of IFN-like responses.
Given a suspected case of EDMD with a lack of relevant family history, we sequenced the lamin A/C gene (LMNA). The gene was found to include the heterozygous variant c.1588C>T, leading to a missense mutation with substitution of p.Leu530Phe, resulting in an altered protein; the in silico analysis confirmed the pathogenicity of this mutation.
The effect of age on increasing LMNA expression levels in control samples seems to be disrupted by the development of Alzheimer's disease pathology.
TPR contributes to the organization of the nuclear lamina and in cooperation with lamin B1 and lamin A-C guards the interphase assembly of nuclear pore complexes.
The cells with higher migration ability tend to have enhanced differentiation potential, while the optimum amount of lamin A/C in migration and differentiation of MSCs is in conflict. This contrary phenomenon may be the result of mechanical microenvironment modulation.
We showed here that NAD+ salvage pathway was altered in the heart of mouse and human carrying LMNA mutation, leading to an alteration of one of NAD+ co-substrate enzymes, PARP-1
By integrating extracellular mechanical and biochemical signals, lamin A/C regulates multiple intracellular events including mesenchymal stem cell fate determination. (Review)
abnormal lamin. proteins trigger paracrine senescence through GATA4-dependent pathway in human mesenchymal stem cells.
some LMNA mutations may be associated with a favourable prognosis and a low risk of sudden death. Protein expression studies suggested that a severe outcome was associated with the expression of high amounts of mutated protein.
The lipodystrophic hotspot LMNA p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks in type 2 familial partial lipodystrophy.
Lowered lamin A expression in circulating osteoprogenitor cells is a strong indicator of frailty.
Lamin A/C tethered SUN2 to the nucleosomes 1 and 2 of the HIV-1 5'-LTR to block the initiation and elongation of HIV-1 transcription.
The finding of a new LMNA pathologic gene variant in this patient increases the options for genetic testing of individuals with restrictive cardiomyopathy.
Lamin A-C interaction with Nestin and its role in the tumor senescence.Nestin stabilizes lamin A-C to protect tumor cells from senescence.
Among the 120 dilated cardiomyopathy patients 13 (10.8%) had LMNA variants. A novel recurrent LMNA E115M variant was the most frequent in familial DCM.
lamin A/C interacts with Notch signaling, thereby influencing cellular differentiation, and point mutation in LMNA could halt this interaction
Mutations in LMNA cause autosomal dominant severe heart disease, accounting for 10% of Dilated Cardiomyopathy .
mouse lamin A dC50 cDNA encoding progerin that lacks 50 amino acid residues at C-terminus depresses osteoblast differentiation in both early and late stages, and it negatively regulates beta-catenin activity interacting with GSK-3beta in cytoplasm.
Lamin A/C mediates Th1 polarization by a mechanism involving T-bet and IFNgamma production as key regulator of Th1 differentiation in response to viral and intracellular parasite infections.
Collectively, our novel results provide therapeutic insights into LMNA cardiomyopathy
we show that the H222P amino acid substitution in lamin A enhances its binding to ERK1/2 and increases sequestration at the nuclear envelope. Finally, we show that genetic deletion of Dusp4 has beneficial effects on heart function and prolongs survival in LmnaH222P/H222P mice. These results further establish Dusp4 as a key contributor to the pathogenesis of LMNA cardiomyopathy and a potential target for drug therapy.
Data show that lamin A/C expressing cells can form an actin cap to resist nuclear deformation in response to physiological mechanical stresses.
THE ROLE OF LMNA MUTATIONS IN MYOGENIC DIFFERENTIATION OF PRIMARY SATELLITE CELLS AND C2C12 CELLS.
Itm2a knockdown is sufficient to rescue the inhibitory effects of lamin A WT and R482W mutant overexpression on 3T3-L1 differentiation.
Using the thin film method combined with sample specific finite element modeling, we quantitatively showed a fivefold lower contractile stress generation of Lmna knockout embryonic fibroblasts (MEFs) as compared to wild-type MEFs. Via fluorescence microscopy it was demonstrated that the lower contractile stress generation was associated with an impaired actin stress fiber organization with thinner actin fibers.
Lmna gene product might play a crucial role in the ChAT-dependent molecular differentiation cascade.
Heterozygous Lmna(delK32/+) (Het) mice had similar cardiac function to wild-type (Wt) before exercise; after 5 weeks strenuous running, Het mice showed cardiac dysfunction and dilation without visible changes in cardiac morphology, molecular remodelling or nuclear structure compared to Wt exercised and Het sedentary mice. Skeletal muscle ex vivo contractile function remained unaffected in Het exercised mice.
Alterations in ventricular myocytes ion channel properties may contribute to arrhythmia and sudden cardiac death in LmnaN195K mutation-related Familial Dilated Cardiomyopathy.
our findings indicate that altered mTOR signaling in Lmna(-/-) mice leads to a lipodystrophic phenotype that can be rescued with rapamycin, highlighting the effect of loss of adipose tissue in Lmna(-/-) mice and the consequences of altered mTOR signaling
results suggest that lamin A plays important roles in maintaining the osteoblast differentiation and function
these findings show that cardiac ERK1/2 activity is modulated in part by TGF-b/Smad signaling, leading to altered activation of CTGF/CCN2 to mediate fibrosis and alter cardiac function. This identifies a novel mechanism in the development of LMNA cardiomyopathy.
Activation of WNT/b-catenin activity improved cardiac contractility and ameliorated intraventricular conduction defects in LmnaH222P/H222P mice, which was associated with increased expression of myocardial connexin 43. These results indicate that decreased WNT/b-catenin contributes to the pathophysiology of LMNA cardiomyopathy and that drugs activating b-catenin may be beneficial in affected individuals
SUMO1 conjugation of RB and Lamin A/C is modulated by the SUMO protease SENP1 and that sumoylation of both proteins is required for their interaction.
Lmna-deficient cells show a compromised strain avoidance response, which is completely abolished when topographical cues and uniaxial strain are applied along the same direction.
While the distribution patterns of both lamins closely paralleled the respective stages of mitosis, Nup160 localization in metaphase oocytes corresponded to that in mitotic prometaphase rather than metaphase.
Study provides evidence that baculovirus infection induced lamin B phosphorylation and disruption of the nuclear lamina.
findings reveal coordination of AGO2 and LaminB function to dictate genome architecture and thereby regulate gene expression
The loss of lamin-B leads to systemic inflammation and aging.
nuclear Wash interacts with B-type Lamin (Lamin Dm0), and, like Lamin, Wash associates with constitutive heterochromatin
of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C
Rab5 associated in vivo with nuclear Lamin and mushroom body defect (Mud), the Drosophila counterpart of nuclear mitotic apparatus protein (NuMA).
Kugelkern and lamin Dm0 affect nuclear shape without requiring filament formation or the presence of a classical nuclear lamina.
Lamin mutation is associated with neuromuscular defects and premature aging.
analysis of Drosophila and human A-type lamins
prometaphase spindle can be made robust to natural fluctuations in motor ratios by a disassembling lamin-B envelope.
Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation.
Molecular interactions with lamin Dm0 may link JIL-1 kinase to nuclear morphology and integrity of nurse cells during oogenesis.
The lamin Dm0 allele Ari3 acts as an enhancer of position effect variegation of the wm4 allele in Drosophila.
Both lamin Dm0 and C. elegans Ce-lamin bind directly to histone H2A in vitro and this binding requires the nuclear localization signal
Induced expression of the farnesylated lamina proteins Lamin B and Kugelkern cause aberrant nuclear shapes and reduce the lifespan of adult flies.
developmental disorders caused by lesions in the B-type lamins and interacting proteins
results have important implications for understanding the tissue-specific regulation and functions of the lamin A gene
The induction of embryonic senescence and laminopathies in zebrafish harboring disturbed expressions of the lamin A gene, is described.
These results indicate that thyroid hormone-regulated expression of nuclear lamin A and LIII closely correlates with dedifferentiation of the epithelial cells in the X. laevis intestine.
LIII filaments appear identical to the endogenous lamina, whereas lamin B2 assembles into filaments that are organized less precisely; Lamin A induces sheets of thicker filaments on the endogenous lamina and increases the rigidity of the nuclear envelope
Ectopic expression of prelamin A in early Xenopus embryos induces apoptosis.
Both anti-lamin A/C and anti-lamin B staining were clearly present in all embryonic stages.
A study mapping the location of procine lamin type A to chromosome 4q is presented.
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
70 kDa lamin
, lamin A/C-like 1
, renal carcinoma antigen NY-REN-32
, lamin C
, B-type lamin
, intermediate filament-like lamina
, lamin A
, lamin B
, lamin D
, lamin D[]
, lamin D[[m]]0
, lamin D[[o]]
, lamin Dm0
, lamin Dm[]
, lamin Dmo
, nuclear lamin
, lamin C2
, lamin A/C