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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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1 | ABIN112346 | FACS IHC (fro) IF WB | Mouse | IgG1 | Log in to see | 131C3 | 3 | |||
1 | ABIN2668135 | ICC IF WB | Mouse | IgG | Log in to see | 3A6-4C11 | 0 | |||
-2.167049 | ABIN4330009 | CyTOF FACS ICC IF IHC IHC (fro) WB | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | ||
-12.929095 | ABIN4330012 | FACS ICC IF IHC IHC (fro) WB | DyLight 350 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN4330017 | FACS ICC IF IHC IHC (fro) WB | DyLight 755 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN4330028 | FACS ICC IF IHC IHC (fro) WB | Alexa Fluor 488 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN4330015 | FACS ICC IF IHC IHC (fro) WB | PerCP | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN4330029 | FACS ICC IF IHC IHC (fro) WB | Alexa Fluor 647 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN4330030 | FACS ICC IF IHC IHC (fro) WB | Alexa Fluor 700 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN4330018 | FACS ICC IF IHC IHC (fro) WB | DyLight 488 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN4330013 | FACS ICC IF IHC IHC (fro) WB | DyLight 405 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN4330020 | FACS ICC IF IHC IHC (fro) WB | DyLight 680 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN4330027 | FACS ICC IF IHC IHC (fro) WB | Alexa Fluor 405 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN5946834 | FACS ICC IF IHC IHC (fro) | Janelia Fluor® 646 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 | |
-12.929095 | ABIN5946833 | FACS ICC IF IHC IHC (fro) | Janelia Fluor® 549 | Mouse | IgG1 | AA 319-566 | Log in to see | 131C3 | 0 |
General |
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Antigen | Lamin A/C (LMNA) Antibodies |
Epitope | AA 430-545 Alternatives |
Reactivity | Hamster, Human, Monkey, Mouse (Murine), Rat (Rattus) Alternatives |
Host | Mouse Alternatives |
Clonality (Clone) | |
Conjugate | This Lamin A/C antibody is un-conjugated Alternatives |
Application |
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Alternatives
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3 references available |
Supplier | Log in to see |
Product Details anti-Lamin A/C AntibodyTarget Details Lamin A/C Application Details Handling References for anti-Lamin A/C antibody (ABIN2668844) Images |
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Purification | Culture Supernatant |
Immunogen | This Lamin A/C antibody was raised against a recombinant protein corresponding to amino acids 430-545 of human Lamin A. |
Clone | 3A6-4C11 |
Isotype | IgG |
Plasmids, Primers & others | |
Target Details Lamin A/CProduct Details anti-Lamin A/C Antibody Application Details Handling References for anti-Lamin A/C antibody (ABIN2668844) Images back to top |
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Antigen | |
Alternative Name | Lamin A/C (LMNA Antibody Abstract) |
Background | Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamins A and Lamins C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization results in disruption of DNA replication, transcription and RNA processing. |
Molecular Weight | 75 kDa |
Gene ID | 4000 |
Pathways | Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus |
Application DetailsProduct Details anti-Lamin A/C Antibody Target Details Lamin A/C Handling References for anti-Lamin A/C antibody (ABIN2668844) Images back to top |
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Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
HandlingProduct Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details References for anti-Lamin A/C antibody (ABIN2668844) Images back to top |
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Concentration | 1 μg/μL |
Buffer | Cell culture supernatant containing mouse IgG, 30 % glycerol, 0.035 % sodium azide. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice |
Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
Storage | -20 °C |
Storage Comment | Antibodies in solution can be stored at -20 °C for 2 years. |
Expiry Date | 6 months |
References for anti-Lamin A/C antibody (ABIN2668844)Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Handling Images back to top |
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Product cited in: |
Gesson, Rescheneder, Skoruppa, von Haeseler, Dechat, Foisner: "A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha." in: Genome research, Vol. 26, Issue 4, pp. 462-73, 2016 Kim, Zheng: "Generation and characterization of a conditional deletion allele for Lmna in mice." in: Biochemical and biophysical research communications, Vol. 440, Issue 1, pp. 8-13, 2013 Eckersley-Maslin, Bergmann, Lazar, Spector: "Lamin A/C is expressed in pluripotent mouse embryonic stem cells." in: Nucleus (Austin, Tex.), Vol. 4, Issue 1, pp. 53-60, 2013 |
ImagesProduct Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Handling References for anti-Lamin A/C antibody (ABIN2668844) back to top |
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Supplier Images |