anti-Human Lamin A/C antibody for Western Blotting

Recommended Lamin A/C Antibody (supplied by: Log in to see )

Antigen
Lamin A/C (LMNA) Antibodies
  • CDCD1
  • CDDC
  • CMD1A
  • CMT2B1
  • EMD2
  • FPL
  • FPLD
  • FPLD2
  • HGPS
  • IDC
  • LDP1
  • LFP
  • LGMD1B
  • LMN1
  • LMNC
  • LMNL1
  • PRO1
  • Dhe
  • 2459
  • 74/76
  • CG6944
  • D5
  • DM[[O]]
  • Dm
  • Dm(0)
  • Dm0
  • Dm1
  • Dm2
  • DmLamin
  • DmO
  • Dm[[0]]
  • Dm[[1]]
  • Dm[[2]]
  • Dm[[mit]]
  • Dm[[o]]
  • Dmel\\CG6944
  • Dmo
  • LAM
  • Lam Dm[[0]]
  • Lam(Dm0)
  • LamDm[[0]]
  • LamDm[[o]]
  • Lam[[Dm0]]
  • Lamin Dm[[0]]
  • jf27
  • l(2)04643
  • l(2)25Ec
  • l(2)gdh-7
  • l(2)gdh7
  • l(2)jf27
  • lam
  • lamDm0
  • lamDm[[0]]
  • lamin
  • lamin Dm0
  • lamin Dm[[0]]
  • misg
  • nlam
  • cb948
  • fk66d12
  • wu:fk66d12
  • lmna-A
  • fpl
  • idc
  • lfp
  • cddc
  • emd2
  • fpld
  • hgps
  • ldp1
  • lmn1
  • lmnc
  • pro1
  • cdcd1
  • cmd1a
  • cmt2b1
  • lgmd1b
  • Lamin-A
  • lamin-L(III)-like
  • lamin A/C
  • lamin A
  • Lamin
  • lamin A/C L homeolog
  • lamin-L(III)-like
  • LMNA
  • Lmna
  • Lam
  • lmna
  • lmna.L
  • LMINA
Epitope
AA 481-646
37
26
25
22
21
18
17
13
11
11
10
9
8
7
7
6
5
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
457
281
246
104
54
53
25
22
17
10
10
9
5
5
4
4
3
3
2
2
2
1
1
1
1
1
Host
Rabbit
243
219
5
3
Clonality
Polyclonal
Conjugate
This Lamin A/C antibody is un-conjugated
13
12
10
7
7
7
7
6
6
6
6
6
6
6
5
5
4
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
420
206
205
163
129
117
76
73
56
17
15
11
2
2
1
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

Catalog No. ABIN3043295
$ 280.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
3.0650759 ABIN2668844 ICC IF WB Mouse IgG AA 430-545 Log in to see 3A6-4C11 3
3.0650759 ABIN3043695 ICC IHC (p) WB Rabbit IgG AA 455-469, C-Term Log in to see Polyclonal 2
3.0650759 ABIN3020785 IHC WB Rabbit IgG Log in to see Polyclonal 0
3.0650759 ABIN2854942 ICC IF IP IHC (p) WB Rabbit IgG Center Log in to see Polyclonal 0
3.0650759 ABIN261550 ICC IHC (fro) IF IHC WB Mouse IgG2b Log in to see mab636 1
3.0650759 ABIN2988538 IF/ICC IHC WB Rabbit IgG Log in to see Polyclonal 0
3.0650759 ABIN4330010 ICC IF IHC IHC (p) IP WB Rabbit IgG Center Log in to see Polyclonal 0
3.0650759 ABIN2856820 IHC (p) WB Rabbit IgG Center Log in to see Polyclonal 0
3.0650759 ABIN2854943 ICC IF IP IHC (p) WB Rabbit IgG Center Log in to see Polyclonal 0
3.0650759 ABIN2706460 IC IF IP IHC WB Rabbit pSer392 Log in to see Polyclonal 0
3.0650759 ABIN2706457 IC IF IP IHC WB Rabbit Center Log in to see Polyclonal 0
3.0650759 ABIN2706459 IHC WB Rabbit Center Log in to see Polyclonal 0
3.0650759 ABIN2706458 IC IF IHC WB Rabbit Center Log in to see Polyclonal 0
3.0650759 ABIN1532183 ELISA WB Rabbit IgG AA 2-51, pSer22 Log in to see Polyclonal 1
3.0650759 ABIN1533204 ELISA WB Rabbit IgG AA 2-51 Log in to see Polyclonal 1
3.0650759 ABIN4330049 ELISA ICC IF IP WB Mouse IgG1 kappa Log in to see 12A-2F5 1
3.0650759 ABIN4880370 ELISA IHC WB Mouse IgG1 Log in to see 4E7 0
3.0650759 ABIN223025 IHC WB Rabbit IgG Log in to see Polyclonal 0
3.0650759 ABIN1531335 IF IHC ELISA WB Rabbit IgG AA 361-410, pSer392 Log in to see Polyclonal 0
3.0650759 ABIN1532355 IF IHC ELISA WB Rabbit IgG AA 361-410 Log in to see Polyclonal 0

General

Antigen Lamin A/C (LMNA) Antibodies
Epitope AA 481-646
(37), (26), (25), (22), (21), (18), (17), (13), (11), (11), (10), (9), (8), (7), (7), (6), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(457), (281), (246), (104), (54), (53), (25), (22), (17), (10), (10), (9), (5), (5), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(243), (219), (5), (3)
Clonality
Polyclonal
Conjugate This Lamin A/C antibody is un-conjugated
(13), (12), (10), (7), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (5), (5), (4), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(420), (206), (205), (163), (129), (117), (76), (73), (56), (17), (15), (11), (2), (2), (1), (1), (1)
Pubmed 2 references available
Supplier Log in to see

Product Details anti-Lamin A/C Antibody

Target Details Lamin A/C Application Details Handling References for anti-Lamin A/C antibody (ABIN3043295) Images
Purpose Rabbit IgG polyclonal antibody for Prelamin-A/C(LMNA) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Prelamin-A/C(LMNA) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: lamin A/C
Protein Name: Prelamin-A/C
Purification Immunogen affinity purified.
Immunogen E.coli-derived human Lamin A/C recombinant protein (Position: Y481-Y646). Human Lamin A/C shares 90% and 92% amino acid (aa) sequence identity with mouse and rat Lamin A/C, respectively.
Isotype IgG
Plasmids, Primers & others

Target Details Lamin A/C

Product Details anti-Lamin A/C Antibody Application Details Handling References for anti-Lamin A/C antibody (ABIN3043295) Images back to top
Antigen
Alternative Name LMNA (LMNA Antibody Abstract)
Background Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A,B and C. The lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C is mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.

Synonyms: 70 kDa lamin antibody|CDCD1 antibody|CDDC antibody|CMD1A antibody|CMT2B1 antibody|EMD2 antibody|FPL antibody|FPLD antibody|HGPS antibody|IDC antibody|LAMIN A antibody|lamin A/C antibody|LAMIN C antibody|Lamin-A/C antibody|LDP1 antibody|LFP antibody|LGMD1B antibody|LMN 1 antibody|LMN A antibody|LMN C antibody|LMN1 antibody|LMNA antibody|LMNA_HUMAN antibody|LMNC antibody|NY REN 32 antigen antibody|PRO1 antibody|Renal carcinoma antigen NY-REN-32 antibody
Gene ID 4000
UniProt P02545
Pathways Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus

Application Details

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Handling References for anti-Lamin A/C antibody (ABIN3043295) Images back to top
Application Notes WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Lamin A/C is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Comment

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

Restrictions For Research Use only

Handling

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details References for anti-Lamin A/C antibody (ABIN3043295) Images back to top
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-Lamin A/C antibody (ABIN3043295)

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Handling Images back to top
Product cited in:

Liu, Ma, Wu, Li, Zhang, Han, Wang, Reindl, Wu, Ma: "Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-?B signaling." in: BMC cancer, Vol. 14, pp. 686, 2014

Yang, Liu, Zhu, Zhang, Xi, Hu, He, Jiang: "Human peripheral nerve-derived scaffold for tissue-engineered nerve grafts: histology and biocompatibility analysis." in: Journal of biomedical materials research. Part B, Applied biomaterials, Vol. 96, Issue 1, pp. 25-33, 2010

Images

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Handling References for anti-Lamin A/C antibody (ABIN3043295) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (AA 481-646) antibody (ABIN3043295) Anti- Lamin A Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (AA 481-646) antibody (ABIN3043295) Anti- Lamin A Picoband antibody, ICC ICC: A549 Cell
Western Blotting (WB) image for anti-Lamin A/C (LMNA) (AA 481-646) antibody (ABIN3043295) Anti- Lamin A Picoband antibody, Western blotting All lanes: Anti Lamin A at 0.5ug/m...
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (AA 481-646) antibody (ABIN3043295) Anti- Lamin A Picoband antibody, IHC(P) IHC(P): Mouse Intestine Tissue
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (AA 481-646) antibody (ABIN3043295) Anti- Lamin A Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue
Western Blotting (WB) image for anti-Lamin A/C (LMNA) (AA 481-646) antibody (ABIN3043295) Anti- Lamin A Picoband antibody, Western blottingAll lanes: Anti Lamin A at 0.5ug/ml...