anti-Human Lamin A/C antibody for Western Blotting

Recommended Lamin A/C Antibody (supplied by: Log in to see )

Antigen
Lamin A/C (LMNA) Antibodies
  • CDCD1
  • CDDC
  • CMD1A
  • CMT2B1
  • EMD2
  • FPL
  • FPLD
  • FPLD2
  • HGPS
  • IDC
  • LDP1
  • LFP
  • LGMD1B
  • LMN1
  • LMNC
  • LMNL1
  • PRO1
  • Dhe
  • 2459
  • 74/76
  • CG6944
  • D5
  • DM[[O]]
  • Dm
  • Dm(0)
  • Dm0
  • Dm1
  • Dm2
  • DmLamin
  • DmO
  • Dm[[0]]
  • Dm[[1]]
  • Dm[[2]]
  • Dm[[mit]]
  • Dm[[o]]
  • Dmel\\CG6944
  • Dmo
  • LAM
  • Lam Dm[[0]]
  • Lam(Dm0)
  • LamDm[[0]]
  • LamDm[[o]]
  • Lam[[Dm0]]
  • Lamin Dm[[0]]
  • jf27
  • l(2)04643
  • l(2)25Ec
  • l(2)gdh-7
  • l(2)gdh7
  • l(2)jf27
  • lam
  • lamDm0
  • lamDm[[0]]
  • lamin
  • lamin Dm0
  • lamin Dm[[0]]
  • misg
  • nlam
  • cb948
  • fk66d12
  • wu:fk66d12
  • lmna-A
  • fpl
  • idc
  • lfp
  • cddc
  • emd2
  • fpld
  • hgps
  • ldp1
  • lmn1
  • lmnc
  • pro1
  • cdcd1
  • cmd1a
  • cmt2b1
  • lgmd1b
  • Lamin-A
  • lamin-L(III)-like
  • lamin A/C
  • lamin A
  • Lamin
  • lamin A/C L homeolog
  • lamin-L(III)-like
  • LMNA
  • Lmna
  • Lam
  • lmna
  • lmna.L
  • LMINA
Epitope
AA 455-469, C-Term
36
25
24
21
20
18
17
12
11
11
9
9
8
7
7
6
4
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
443
270
235
99
53
49
25
22
17
10
10
9
5
5
4
4
3
3
2
2
2
1
1
1
1
1
Host
Rabbit
237
211
5
3
Clonality
Polyclonal
Conjugate
This Lamin A/C antibody is un-conjugated
13
12
10
7
7
6
6
6
6
6
6
6
5
5
5
5
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
406
206
195
155
120
111
75
72
53
17
15
11
2
2
1
1
1
Options
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Catalog No. ABIN3043695
$ 280.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
3.1357021 ABIN3043295 ICC IHC (p) WB Rabbit IgG AA 481-646 Log in to see Polyclonal 2
3.1357021 ABIN3020785 IHC WB Rabbit IgG Log in to see Polyclonal 0
3.1357021 ABIN6256311 ELISA ICC IF IHC WB Rabbit IgG pSer392 Log in to see Polyclonal 0
3.1357021 ABIN2854942 ICC IF IP IHC (p) WB Rabbit IgG Center Log in to see Polyclonal 0
3.1357021 ABIN261550 ICC IHC (fro) IF IHC WB Mouse IgG2b Log in to see mab636 1
3.1357021 ABIN2988538 IF/ICC IHC WB Rabbit IgG Log in to see Polyclonal 0
3.1357021 ABIN4330010 ICC IF IHC IHC (p) IP WB Rabbit IgG Center Log in to see Polyclonal 0
3.1357021 ABIN2856820 IHC (p) WB Rabbit IgG Center Log in to see Polyclonal 0
3.1357021 ABIN2854943 ICC IF IP IHC (p) WB Rabbit IgG Center Log in to see Polyclonal 0
3.1357021 ABIN2706460 IC IF IP IHC WB Rabbit pSer392 Log in to see Polyclonal 0
3.1357021 ABIN2706457 IC IF IP IHC WB Rabbit Center Log in to see Polyclonal 0
3.1357021 ABIN2706459 IHC WB Rabbit Center Log in to see Polyclonal 0
3.1357021 ABIN2706458 IC IF IHC WB Rabbit Center Log in to see Polyclonal 0
3.1357021 ABIN1532183 ELISA WB Rabbit IgG AA 2-51, pSer22 Log in to see Polyclonal 1
3.1357021 ABIN1533204 ELISA WB Rabbit IgG AA 2-51 Log in to see Polyclonal 1
3.1357021 ABIN6262903 ELISA ICC IF IHC WB Rabbit IgG Log in to see Polyclonal 0
3.1357021 ABIN4880370 ELISA IHC WB Mouse IgG1 Log in to see 4E7 0
3.1357021 ABIN223025 IHC WB Rabbit IgG Log in to see Polyclonal 0
3.1357021 ABIN1531335 IF IHC ELISA WB Rabbit IgG AA 361-410, pSer392 Log in to see Polyclonal 0
3.1357021 ABIN1532355 IF IHC ELISA WB Rabbit IgG AA 361-410 Log in to see Polyclonal 0

General

Antigen Lamin A/C (LMNA) Antibodies
Epitope AA 455-469, C-Term
(36), (25), (24), (21), (20), (18), (17), (12), (11), (11), (9), (9), (8), (7), (7), (6), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(443), (270), (235), (99), (53), (49), (25), (22), (17), (10), (10), (9), (5), (5), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(237), (211), (5), (3)
Clonality
Polyclonal
Conjugate This Lamin A/C antibody is un-conjugated
(13), (12), (10), (7), (7), (6), (6), (6), (6), (6), (6), (6), (5), (5), (5), (5), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(406), (206), (195), (155), (120), (111), (75), (72), (53), (17), (15), (11), (2), (2), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-Lamin A/C Antibody

Target Details Lamin A/C Application Details Handling References for anti-Lamin A/C antibody (ABIN3043695) Images
Purpose Rabbit IgG polyclonal antibody for Prelamin-A/C(LMNA) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Sequence RNKSNEDQSM GNWQI
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Prelamin-A/C(LMNA) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: lamin A/C
Protein Name: Prelamin-A/C
Purification Immunogen affinity purified.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin A/C(455-469aa RNKSNEDQSMGNWQI), identical to the related rat and mouse sequences.
Isotype IgG
Plasmids, Primers & others

Target Details Lamin A/C

Product Details anti-Lamin A/C Antibody Application Details Handling References for anti-Lamin A/C antibody (ABIN3043695) Images back to top
Antigen
Alternative Name LMNA (LMNA Antibody Abstract)
Background Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A,B and C. The lamin A/C(LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.

Synonyms: 70 kDa Lamin antibody|Cardiomyopathy dilated 1A(autosomal dominant) antibody|CDCD1 antibody|CDDC antibody|Charcot Marie Tooth Disease Axonal Type 2B1 antibody|CMD1A antibody|CMT2B1 antibody|EMD2 antibody|FPL antibody|FPLD antibody|FPLD2 antibody|HGPS antibody|IDC antibody|Lamin A/C antibody|Lamin A/C Isoform 1 Precursor antibody|Lamin A/C Isoform 2 antibody|Lamin A/C Isoform 3 antibody|Lamin A/C like 1 antibody|Lamin-A/C antibody|LDP1 antibody|LFP antibody|LGMD1B antibody|Limb girdle muscular dystrophy 1B(autosomal dominant) antibody|LMN 1 antibody|LMN A antibody|LMN C antibody|LMN1 antibody|LMNA antibody|LMNA_HUMAN antibody|LMNC antibody|NY REN 32 antigen antibody|Prelamin A/C antibody|PRO1 antibody|Progeria 1(Hutchinson Gilford Type) antibody|Renal carcinoma antigen NY REN 32 antibody|Renal carcinoma antigen NY-REN-32 antibody|Renal carcinoma antigen NYREN32 antibody
UniProt P02545
Pathways Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus

Application Details

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Handling References for anti-Lamin A/C antibody (ABIN3043695) Images back to top
Application Notes WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Comment

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

Restrictions For Research Use only

Handling

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details References for anti-Lamin A/C antibody (ABIN3043695) Images back to top
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Thimerosal (Merthiolate), Sodium azide
Precaution of Use This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-Lamin A/C antibody (ABIN3043695)

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Handling Images back to top
Product cited in:

Liu, Ma, Wu, Li, Zhang, Han, Wang, Reindl, Wu, Ma: "Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-?B signaling." in: BMC cancer, Vol. 14, pp. 686, 2014

Yang, Liu, Zhu, Zhang, Xi, Hu, He, Jiang: "Human peripheral nerve-derived scaffold for tissue-engineered nerve grafts: histology and biocompatibility analysis." in: Journal of biomedical materials research. Part B, Applied biomaterials, Vol. 96, Issue 1, pp. 25-33, 2010

Images

Product Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Handling References for anti-Lamin A/C antibody (ABIN3043695) back to top
Supplier Images
Western Blotting (WB) image for anti-Lamin A/C (LMNA) (AA 455-469), (C-Term) antibody (ABIN3043695) Anti-Lamin A+C antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: A431 Cell ...
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (AA 455-469), (C-Term) antibody (ABIN3043695) Anti-Lamin A+C antibody, IHC(P) IHC(P): Human Lung Cancer Tissue
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (AA 455-469), (C-Term) antibody (ABIN3043695) Anti-Lamin A+C antibody, IHC(P) IHC(P): Rat Intestine Tissue
Immunohistochemistry (IHC) image for anti-Lamin A/C (LMNA) (AA 455-469), (C-Term) antibody (ABIN3043695) Anti-Lamin A+C antibody, IHC(P) IHC(P): Mouse Intestine Tissue