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General |
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Antigen | Lamin A/C (LMNA) Antibodies |
Reactivity | Human, Mouse (Murine), Rat (Rattus) Alternatives |
Host | Mouse Alternatives |
Clonality (Clone) | |
Conjugate | This Lamin A/C antibody is un-conjugated Alternatives |
Application |
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternatives
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Supplier | Log in to see |
Product Details anti-Lamin A/C AntibodyTarget Details Lamin A/C Application Details Handling Images |
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Specificity | This antibody reacts to LMNA. |
Cross-Reactivity (Details) | Species reactivity (tested):Human, Mouse and Rat. |
Purification | Ascites |
Clone | 4-00E-007 |
Isotype | IgG1 |
Target Details Lamin A/CProduct Details anti-Lamin A/C Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | Lamin-A/C (LMNA) (LMNA Antibody Abstract) |
Background | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.Synonyms: 70 kDa Lamin, LMN1, LMNA, Lamin A, Lamin A + C, Lamin-A/C, NY-REN-32, NYREN32, Nuclear Envelope Marker, Renal carcinoma antigen NY-REN-32 |
Molecular Weight | 74 kDa |
Gene ID | 4000 |
Pathways | Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus |
Application DetailsProduct Details anti-Lamin A/C Antibody Target Details Lamin A/C Handling Images back to top |
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Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
HandlingProduct Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Images back to top |
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Format | Liquid |
ImagesProduct Details anti-Lamin A/C Antibody Target Details Lamin A/C Application Details Handling back to top |
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Supplier Images |