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Human Lamin A/C Protein expressed in Wheat germ - ABIN1309507
Chen, Lin, Chow, Lee: Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cells. in Proteomics 2011
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The loss of lamin-B (show LMNB1 Proteins) leads to systemic inflammation and aging.
nuclear Wash interacts with B-type Lamin (Lamin Dm0), and, like Lamin, Wash associates with constitutive heterochromatin
of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C
Rab5 associated in vivo with nuclear Lamin and mushroom body defect (Mud), the Drosophila counterpart of nuclear mitotic apparatus protein (NuMA).
Kugelkern and lamin Dm0 affect nuclear shape without requiring filament formation or the presence of a classical nuclear lamina.
Lamin mutation is associated with neuromuscular defects and premature aging.
prometaphase spindle can be made robust to natural fluctuations in motor ratios by a disassembling lamin-B (show LMNB1 Proteins) envelope.
Molecular interactions with lamin Dm0 may link JIL-1 kinase to nuclear morphology and integrity of nurse cells during oogenesis.
The lamin Dm0 allele Ari3 acts as an enhancer of position effect variegation of the wm4 allele in Drosophila.
Both lamin Dm0 and C. elegans Ce-lamin bind directly to histone H2A in vitro and this binding requires the nuclear localization signal
results have important implications for understanding the tissue-specific regulation and functions of the lamin A gene
The induction of embryonic senescence and laminopathies in zebrafish harboring disturbed expressions of the lamin A gene, is described.
Heterozygous Lmna(delK32/+) (Het) mice had similar cardiac function to wild-type (Wt) before exercise; after 5 weeks strenuous running, Het mice showed cardiac dysfunction and dilation without visible changes in cardiac morphology, molecular remodelling or nuclear structure compared to Wt exercised and Het sedentary mice. Skeletal muscle ex vivo contractile function remained unaffected in Het exercised mice.
our findings indicate that altered mTOR (show FRAP1 Proteins) signaling in Lmna(-/-) mice leads to a lipodystrophic phenotype that can be rescued with rapamycin, highlighting the effect of loss of adipose tissue in Lmna(-/-) mice and the consequences of altered mTOR (show FRAP1 Proteins) signaling
results suggest that lamin A plays important roles in maintaining the osteoblast differentiation and function
these findings show that cardiac ERK1/2 activity is modulated in part by TGF-b/Smad (show SMAD1 Proteins) signaling, leading to altered activation of CTGF/CCN2 (show CTGF Proteins) to mediate fibrosis and alter cardiac function. This identifies a novel mechanism in the development of LMNA cardiomyopathy.
Activation of WNT/b-catenin activity improved cardiac contractility and ameliorated intraventricular conduction defects in LmnaH222P/H222P mice, which was associated with increased expression of myocardial connexin 43. These results indicate that decreased WNT/b-catenin contributes to the pathophysiology of LMNA cardiomyopathy and that drugs activating b-catenin may be beneficial in affected individuals
SUMO1 (show SUMO1 Proteins) conjugation of RB and Lamin A/C is modulated by the SUMO protease SENP1 (show SENP1 Proteins) and that sumoylation of both proteins is required for their interaction.
Lmna-deficient cells show a compromised strain avoidance response, which is completely abolished when topographical cues and uniaxial strain are applied along the same direction.
While the distribution patterns of both lamins closely paralleled the respective stages of mitosis, Nup160 (show NUP160 Proteins) localization in metaphase oocytes corresponded to that in mitotic prometaphase rather than metaphase.
changes in nuclear size and shape, which are mediated by nuclear envelope structural proteins lamin A/C and/or emerin (show EMD Proteins), also impact gene regulation and lineage differentiation in early embryos.
administration of the exon 11 ASO reduced lamin A expression in wild-type mice and progerin expression in an HGPS mouse model.
two novel RNA isoforms of LMNA produced through alternative splicing
Lamin A/C is an autoantigen in Han Chinese patients with confirmed Sjogren's syndrome. Lamin A/C shares similar epitopes with U1RNP (show SNRNP70 Proteins).
it was demonstrated that suspension state promoted the reattachment of breast tumor cells by up-regulating lamin A/C via cytoskeleton disruption. These findings highlight the important role of suspension state for tumor cells in tumor metastasis.
In this report we show that increased self-association propensity of mutant LA modulates the LA-LB1 (show CKAP2 Proteins) interaction and precludes the formation of an otherwise uniform laminar network. Our results might highlight the role of homotypic and heterotypic interactions of LA in the pathogenesis of DCM and hence laminopathies in the broader sense.
Familial partial lipodystrophy type 2 (FPLD2) is caused by an autosomal dominant mutation in the LMNA gene. FPLD2-adipocytes appear to accumulate markers of autophagy and catabolize triglycerides at higher levels than control adipocytes.
we demonstrate that BAF (show BANF1 Proteins) is necessary to modulate prelamin A effects on chromatin structure
Dysmorphic nuclei in patients with an LMNA mutation correlate with the age of heart disease presentation.
These results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 (show GABPA Proteins) response to arsenic and cadmium.
developed a proteomic analysis of plasma samples from a family showing history of dilated cardiomyopathy caused by a LMNA mutation, which may lead to premature death or cardiac transplant
Exome sequencing of the proband revealed an extremely rare missense heterozygous variant c.1711_1712CG>TC; p.(Arg571Ser) in LMNA which was confirmed by Sanger sequencing in both the patients. Interestingly, the mutation had no effect on mRNA splicing or relative expression of lamin A or C mRNA and protein in the lymphoblasts
Both anti-lamin A/C and anti-lamin B (show LMNB1 Proteins) staining were clearly present in all embryonic stages.
A study mapping the location of procine lamin type A to chromosome 4q is presented.
These results indicate that thyroid hormone (show PTH Proteins)-regulated expression of nuclear lamin A and LIII closely correlates with dedifferentiation of the epithelial cells in the X. laevis intestine.
LIII filaments appear identical to the endogenous lamina, whereas lamin B2 (show LMNB2 Proteins) assembles into filaments that are organized less precisely; Lamin A induces sheets of thicker filaments on the endogenous lamina and increases the rigidity of the nuclear envelope
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
, intermediate filament-like lamina
, lamin A
, lamin B
, lamin D
, lamin D[]
, lamin D[[m]]0
, lamin D[[o]]
, lamin Dm0
, lamin Dm[]
, lamin Dmo
, nuclear lamin
, lamin B3
, lamin A/C
, lamin LIII
, lamin C
, 70 kDa lamin
, lamin A/C-like 1
, renal carcinoma antigen NY-REN-32
, lamin C2